PMC:7799378 / 24084-25219 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
982	399-410	Species	denotes	chikungunya	Tax:37124
983	478-487	Species	denotes	influenza	Tax:11309
984	0-11	Chemical	denotes	Chloroquine	MESH:D002738
985	13-15	Chemical	denotes	CQ	MESH:D002738
986	20-36	Chemical	denotes	4-aminoquinoline	MESH:C001920
987	317-319	Chemical	denotes	CQ	MESH:D002738
988	393-395	Chemical	denotes	CQ	MESH:D002738
989	521-539	Chemical	denotes	Hydroxychloroquine	MESH:D006886
990	541-544	Chemical	denotes	HCQ	MESH:D006886
991	565-576	Chemical	denotes	chloroquine	MESH:D002738
992	684-687	Chemical	denotes	HCQ	MESH:D006886
993	787-789	Chemical	denotes	CQ	MESH:D002738
994	793-796	Chemical	denotes	HCQ	MESH:D006886
995	955-958	Chemical	denotes	HCQ	MESH:D006886
996	1060-1071	Chemical	denotes	chloroquine	MESH:D002738
997	80-87	Disease	denotes	malaria	MESH:D008288
998	92-102	Disease	denotes	amoebiasis	MESH:D000562
999	143-162	Disease	denotes	autoimmune diseases	MESH:D001327
1000	174-193	Disease	denotes	lupus erythematosus	MESH:D008180
1001	198-218	Disease	denotes	rheumatoid arthritis	MESH:D001172
1002	255-267	Disease	denotes	inflammation	MESH:D007249
1003	421-435	Disease	denotes	HCV infections	MESH:D006526
1004	492-509	Disease	denotes	dengue infections	MESH:D003715
1005	599-607	Disease	denotes	COVID-19	MESH:C000657245
1006	696-704	Disease	denotes	COVID-19	MESH:C000657245
1007	819-847	Disease	denotes	hemolysis in G6PD deficiency	MESH:D006461
1008	929-938	Disease	denotes	hemolysis	MESH:D006461
1009	975-989	Disease	denotes	G6PD-deficient	MESH:D005955
1010	1043-1052	Disease	denotes	hemolysis	MESH:D006461
1011	1084-1098	Disease	denotes	G6PD-deficient	MESH:D005955

Id	Subject	Object	Predicate	Lexical cue
T195	0-113	Sentence	denotes	Chloroquine (CQ), a 4-aminoquinoline drug, is commonly used in the treatment of malaria and amoebiasis [122,123].
T196	114-302	Sentence	denotes	It is also used for treating autoimmune diseases, including lupus erythematosus and rheumatoid arthritis, due to its capacity for modulating inflammation and the immune response [124,125].
T197	303-355	Sentence	denotes	The effect of CQ on certain viruses is inconclusive.
T198	356-520	Sentence	denotes	A positive response is observed with CQ in chikungunya, HIV, and HCV infections [126–129], whereas it is not effective in influenza and dengue infections [126,130].
T199	521-662	Sentence	denotes	Hydroxychloroquine (HCQ) is a derivative of chloroquine and its treatment for COVID-19 is currently being evaluated in clinical trials [131].
T200	663-758	Sentence	denotes	The potential use of HCQ against COVID-19 may raise safety issues in certain populations [132].
T201	759-858	Sentence	denotes	Recent reports suggest that CQ or HCQ is possibly linked to hemolysis in G6PD deficiency [133–135].
T202	859-1012	Sentence	denotes	However, two large retrospective studies indicated that no episode of hemolysis was found after HCQ treatment among G6PD-deficient individuals [136,137].
T203	1013-1135	Sentence	denotes	Hence, the claim that oxidant hemolysis due to chloroquine exposure in G6PD-deficient individuals remains unsettled [138].

Id	Subject	Object	Predicate	Lexical cue	hp_id
T43	143-162	Phenotype	denotes	autoimmune diseases	http://purl.obolibrary.org/obo/HP_0002960
T44	198-218	Phenotype	denotes	rheumatoid arthritis	http://purl.obolibrary.org/obo/HP_0001370
T45	918-938	Phenotype	denotes	episode of hemolysis	http://purl.obolibrary.org/obo/HP_0004802