PMC:7799378 / 19607-20745 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"806","span":{"begin":410,"end":419},"obj":"Gene"},{"id":"807","span":{"begin":485,"end":490},"obj":"Gene"},{"id":"808","span":{"begin":495,"end":500},"obj":"Gene"},{"id":"809","span":{"begin":627,"end":663},"obj":"Gene"},{"id":"810","span":{"begin":665,"end":670},"obj":"Gene"},{"id":"811","span":{"begin":827,"end":832},"obj":"Gene"},{"id":"812","span":{"begin":770,"end":788},"obj":"Species"},{"id":"813","span":{"begin":789,"end":810},"obj":"Species"},{"id":"814","span":{"begin":812,"end":815},"obj":"Species"},{"id":"815","span":{"begin":90,"end":102},"obj":"Disease"},{"id":"816","span":{"begin":551,"end":576},"obj":"Disease"},{"id":"817","span":{"begin":581,"end":607},"obj":"Disease"},{"id":"818","span":{"begin":891,"end":896},"obj":"Disease"},{"id":"819","span":{"begin":1006,"end":1029},"obj":"Disease"}],"attributes":[{"id":"A806","pred":"tao:has_database_id","subj":"806","obj":"Gene:3553"},{"id":"A807","pred":"tao:has_database_id","subj":"807","obj":"Gene:3552"},{"id":"A808","pred":"tao:has_database_id","subj":"808","obj":"Gene:3606"},{"id":"A809","pred":"tao:has_database_id","subj":"809","obj":"Gene:114548"},{"id":"A810","pred":"tao:has_database_id","subj":"810","obj":"Gene:114548"},{"id":"A811","pred":"tao:has_database_id","subj":"811","obj":"Gene:114548"},{"id":"A812","pred":"tao:has_database_id","subj":"812","obj":"Tax:694005"},{"id":"A813","pred":"tao:has_database_id","subj":"813","obj":"Tax:11138"},{"id":"A814","pred":"tao:has_database_id","subj":"814","obj":"Tax:11138"},{"id":"A815","pred":"tao:has_database_id","subj":"815","obj":"MESH:D007249"},{"id":"A816","pred":"tao:has_database_id","subj":"816","obj":"MESH:D007249"},{"id":"A817","pred":"tao:has_database_id","subj":"817","obj":"MESH:D056660"},{"id":"A818","pred":"tao:has_database_id","subj":"818","obj":"MESH:D003643"},{"id":"A819","pred":"tao:has_database_id","subj":"819","obj":"MESH:D060825"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The inflammasome is part of the innate immune system that regulates effector cells during inflammation [104–107]. Inflammasomes are cytosolic protein complexes consisting of multiple oligomeric molecules that detect cell-damaging agents and pathogenic factors by recognizing danger-associated molecular patterns (DAMP) and pathogen-associated molecular patterns (PAMP), respectively [104]. Through cleavage of pro-IL-1β and pro-IL-18, they promote the secretion of the active forms of IL-1β and IL-18. Long-term exposure of the host to viruses causes dysregulated inflammation and autoinflammatory disorders. Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is triggered by viral replication and leads to the destruction of viruses [105]. The murine coronavirus mouse hepatitis virus (MHV) activates NLRP3 inflammasomes and induces proinflammatory programmed cell death by panoptosis (pyroptosis, apoptosis, and necroptosis) [106,107]. The deleterious effects on the host due to inflammasome impairment indicate that balanced regulation of inflammasomes is crucial for the immune response and antiviral defense."}

{"project":"LitCovid-sentences","denotations":[{"id":"T161","span":{"begin":0,"end":113},"obj":"Sentence"},{"id":"T162","span":{"begin":114,"end":389},"obj":"Sentence"},{"id":"T163","span":{"begin":390,"end":501},"obj":"Sentence"},{"id":"T164","span":{"begin":502,"end":608},"obj":"Sentence"},{"id":"T165","span":{"begin":609,"end":765},"obj":"Sentence"},{"id":"T166","span":{"begin":766,"end":962},"obj":"Sentence"},{"id":"T167","span":{"begin":963,"end":1138},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The inflammasome is part of the innate immune system that regulates effector cells during inflammation [104–107]. Inflammasomes are cytosolic protein complexes consisting of multiple oligomeric molecules that detect cell-damaging agents and pathogenic factors by recognizing danger-associated molecular patterns (DAMP) and pathogen-associated molecular patterns (PAMP), respectively [104]. Through cleavage of pro-IL-1β and pro-IL-18, they promote the secretion of the active forms of IL-1β and IL-18. Long-term exposure of the host to viruses causes dysregulated inflammation and autoinflammatory disorders. Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is triggered by viral replication and leads to the destruction of viruses [105]. The murine coronavirus mouse hepatitis virus (MHV) activates NLRP3 inflammasomes and induces proinflammatory programmed cell death by panoptosis (pyroptosis, apoptosis, and necroptosis) [106,107]. The deleterious effects on the host due to inflammasome impairment indicate that balanced regulation of inflammasomes is crucial for the immune response and antiviral defense."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T35","span":{"begin":795,"end":804},"obj":"Phenotype"}],"attributes":[{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0012115"}],"text":"The inflammasome is part of the innate immune system that regulates effector cells during inflammation [104–107]. Inflammasomes are cytosolic protein complexes consisting of multiple oligomeric molecules that detect cell-damaging agents and pathogenic factors by recognizing danger-associated molecular patterns (DAMP) and pathogen-associated molecular patterns (PAMP), respectively [104]. Through cleavage of pro-IL-1β and pro-IL-18, they promote the secretion of the active forms of IL-1β and IL-18. Long-term exposure of the host to viruses causes dysregulated inflammation and autoinflammatory disorders. Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is triggered by viral replication and leads to the destruction of viruses [105]. The murine coronavirus mouse hepatitis virus (MHV) activates NLRP3 inflammasomes and induces proinflammatory programmed cell death by panoptosis (pyroptosis, apoptosis, and necroptosis) [106,107]. The deleterious effects on the host due to inflammasome impairment indicate that balanced regulation of inflammasomes is crucial for the immune response and antiviral defense."}