> top > docs > PMC:7799378 > spans > 16939-21781 > annotations

PMC:7799378 / 16939-21781 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
698 54-69 Disease denotes G6PD-deficiency MESH:D005955
699 97-113 Disease denotes viral infections MESH:D001102
715 567-572 Species denotes human Tax:9606
716 690-695 Species denotes human Tax:9606
717 744-771 Species denotes respiratory syncytial virus Tax:12814
718 201-230 Disease denotes bacterial or fungal infection MESH:D001424
719 339-348 Disease denotes infection MESH:D007239
720 573-609 Disease denotes HIV and chikungunya viral infections MESH:D001102
721 655-671 Disease denotes viral infections MESH:D001102
722 730-738 Disease denotes infected MESH:D007239
723 864-882 Disease denotes pulmonary diseases MESH:D008171
724 900-911 Disease denotes lung injury MESH:D055370
725 913-919 Disease denotes asthma MESH:D001249
726 921-925 Disease denotes COPD MESH:D029424
727 927-942 Disease denotes cystic fibrosis MESH:D003550
728 948-957 Disease denotes pneumonia MESH:D011014
729 718-723 CellLine denotes Hep-2 CVCL:1906
742 1176-1180 Gene denotes G6PD Gene:2539
743 1189-1194 Gene denotes NADPH Gene:1666
744 1329-1333 Gene denotes G6PD Gene:2539
745 998-1001 Chemical denotes NAC MESH:D000111
746 1006-1009 Chemical denotes DPI MESH:C007517
747 1245-1255 Chemical denotes superoxide MESH:D013481
748 1534-1549 Disease denotes G6PD deficiency MESH:D005955
749 1597-1611 Disease denotes NOX deficiency MESH:D007153
750 1628-1657 Disease denotes chronic granulomatous disease MESH:D006105
751 1659-1662 Disease denotes CGD MESH:D006105
752 1672-1687 Disease denotes G6PD deficiency MESH:D005955
753 1724-1742 Disease denotes dysfunctional NETs MESH:D009461
773 2030-2038 Gene denotes elastase
774 2529-2536 Gene denotes DNase-1 Gene:1773
775 2572-2577 Gene denotes IL-1β Gene:3552
776 1786-1794 Species denotes patients Tax:9606
777 1983-1991 Species denotes patients Tax:9606
778 2100-2110 Species denotes SARS-CoV-2 Tax:2697049
779 2398-2406 Species denotes patients Tax:9606
780 1777-1785 Disease denotes COVID-19 MESH:C000657245
781 1844-1852 Disease denotes COVID-19 MESH:C000657245
782 1907-1919 Disease denotes organ injury MESH:D009102
783 1925-1934 Disease denotes mortality MESH:D003643
784 1974-1982 Disease denotes COVID-19 MESH:C000657245
785 2075-2083 Disease denotes COVID-19 MESH:C000657245
786 2129-2141 Disease denotes hypertension MESH:D006973
787 2143-2153 Disease denotes thrombosis MESH:D013927
788 2159-2169 Disease denotes vasculitis MESH:D014657
789 2389-2397 Disease denotes COVID-19 MESH:C000657245
790 2437-2446 Disease denotes mortality MESH:D003643
791 2648-2656 Disease denotes COVID-19 MESH:C000657245
806 3078-3087 Gene denotes pro-IL-1β Gene:3553
807 3153-3158 Gene denotes IL-1β Gene:3552
808 3163-3168 Gene denotes IL-18 Gene:3606
809 3295-3331 Gene denotes NLR family pyrin domain containing 3 Gene:114548
810 3333-3338 Gene denotes NLRP3 Gene:114548
811 3495-3500 Gene denotes NLRP3 Gene:114548
812 3438-3456 Species denotes murine coronavirus Tax:694005
813 3457-3478 Species denotes mouse hepatitis virus Tax:11138
814 3480-3483 Species denotes MHV Tax:11138
815 2758-2770 Disease denotes inflammation MESH:D007249
816 3219-3244 Disease denotes dysregulated inflammation MESH:D007249
817 3249-3275 Disease denotes autoinflammatory disorders MESH:D056660
818 3559-3564 Disease denotes death MESH:D003643
819 3674-3697 Disease denotes inflammasome impairment MESH:D060825
841 4200-4205 Gene denotes IL-1β Gene:3552
842 4523-4527 Gene denotes G6PD Gene:2539
843 4650-4654 Gene denotes G6PD Gene:2539
844 4694-4698 Gene denotes G6PD Gene:2539
845 3881-3889 Species denotes patients Tax:9606
846 3956-3964 Species denotes patients Tax:9606
847 4355-4360 Species denotes human Tax:9606
848 4604-4625 Species denotes Staphylococcus aureus Tax:1280
849 4630-4646 Species denotes Escherichia coli Tax:562
850 4266-4269 Chemical denotes ATP MESH:D000255
851 4270-4279 Chemical denotes nigericin MESH:D009550
852 4450-4453 Chemical denotes ROS MESH:D017382
853 4480-4484 Chemical denotes H2O2 MESH:D006861
854 3872-3880 Disease denotes COVID-19 MESH:C000657245
855 3947-3955 Disease denotes COVID-19 MESH:C000657245
856 3991-3998 Disease denotes fitness MESH:D012640
857 4084-4092 Disease denotes COVID-19 MESH:C000657245
858 4170-4185 Disease denotes G6PD deficiency MESH:D005955
859 4342-4347 CellLine denotes THP-1 CVCL:0006
860 4538-4543 CellLine denotes THP-1 CVCL:0006
861 4665-4670 CellLine denotes THP-1 CVCL:0006

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T141 0-113 Sentence denotes Impaired NET formation and inflammasome activation in G6PD-deficiency and its possible effect on viral infections
T142 114-173 Sentence denotes Neutrophils are among the key players in the immune system.
T143 174-323 Sentence denotes The role of neutrophils in bacterial or fungal infection is well known, yet their influence on the anti-viral response has not been established [87].
T144 324-440 Sentence denotes In response to infection, stimulated neutrophils release chromosomal DNA for trapping and killing invading microbes.
T145 441-512 Sentence denotes The chromatin trap is known as the neutrophil extracellular trap (NET).
T146 513-780 Sentence denotes It mediates the control of viruses, such as seen with human HIV and chikungunya viral infections [88, 89], whereas it can contribute to other viral infections, including in non-human primates with SIV and Hep-2 cells infected with respiratory syncytial virus [90,91].
T147 781-963 Sentence denotes The cytotoxic effect on lung epithelium and endothelium has linked NETs to several pulmonary diseases, including acute lung injury, asthma, COPD, cystic fibrosis, and pneumonia [92].
T148 964-1066 Sentence denotes NET formation can be inhibited by NAC and DPI, indicating the involvement of oxidative stress and NOX.
T149 1067-1175 Sentence denotes A metabolic shift towards the PPP is required for the NET formation induced by amyloid fibrils and PMA [93].
T150 1176-1290 Sentence denotes G6PD-derived NADPH can serve as a substrate for NOX, which generates superoxide and stimulates NET formation [17].
T151 1291-1428 Sentence denotes Neutrophils from individuals with the G6PD Taiwan-Hakka variant are equally effective as normal individuals regarding NET formation [94].
T152 1429-1555 Sentence denotes However, defective NET formation and NOX activity are observed in neutrophils of individuals with severe G6PD deficiency [95].
T153 1556-1664 Sentence denotes The absence of NET formation is found in NOX deficiency associated with chronic granulomatous disease (CGD).
T154 1665-1743 Sentence denotes Severe G6PD deficiency may mimic impaired NOX resulting in dysfunctional NETs.
T155 1744-1800 Sentence denotes Elevated NET levels are found in COVID-19 patients [96].
T156 1801-1997 Sentence denotes NET formation is considered as a driver of COVID-19, since NET formation may contribute to tissue damage, organ injury, and mortality as indicated by autopsy specimens from COVID-19 patients [97].
T157 1998-2179 Sentence denotes The by-product of NETs, such as elastase, is involved in the pathogenesis of COVID-19 by facilitating SARS-CoV-2 entry and causing hypertension, thrombosis, and vasculitis [98–100].
T158 2180-2328 Sentence denotes The tissue damage leading to excessive oxidative stress creates a vicious cycle by increasing NET formation and distressing adaptive immunity [101].
T159 2329-2475 Sentence denotes Increased NETs are associated with hyperinflammation and in COVID-19 patients they amplify the severity and mortality associated with the disease.
T160 2476-2667 Sentence denotes Targeting NETs and its feedback loop, with elastase, DNase-1, or inhibitory peptides as well as IL-1β, are potential therapeutic interventions for reducing the severity of COVID-19 [102,103].
T161 2668-2781 Sentence denotes The inflammasome is part of the innate immune system that regulates effector cells during inflammation [104–107].
T162 2782-3057 Sentence denotes Inflammasomes are cytosolic protein complexes consisting of multiple oligomeric molecules that detect cell-damaging agents and pathogenic factors by recognizing danger-associated molecular patterns (DAMP) and pathogen-associated molecular patterns (PAMP), respectively [104].
T163 3058-3169 Sentence denotes Through cleavage of pro-IL-1β and pro-IL-18, they promote the secretion of the active forms of IL-1β and IL-18.
T164 3170-3276 Sentence denotes Long-term exposure of the host to viruses causes dysregulated inflammation and autoinflammatory disorders.
T165 3277-3433 Sentence denotes Activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is triggered by viral replication and leads to the destruction of viruses [105].
T166 3434-3630 Sentence denotes The murine coronavirus mouse hepatitis virus (MHV) activates NLRP3 inflammasomes and induces proinflammatory programmed cell death by panoptosis (pyroptosis, apoptosis, and necroptosis) [106,107].
T167 3631-3806 Sentence denotes The deleterious effects on the host due to inflammasome impairment indicate that balanced regulation of inflammasomes is crucial for the immune response and antiviral defense.
T168 3807-3896 Sentence denotes Inflammasome activation causes a cytokine storm in both SARS and COVID-19 patients [108].
T169 3897-4048 Sentence denotes It is proposed that the heterogeneous response in COVID-19 patients due to the lack of immune fitness fails to properly reduce inflammasome activation.
T170 4049-4169 Sentence denotes This leads to enhanced severity of COVID-19, that is associated with a cytokine storm and extensive tissue damage [109].
T171 4170-4387 Sentence denotes G6PD deficiency downregulates IL-1β expression and impairs inflammasome activation upon LPS and ATP/nigericin stimulation in PBMCs (peripheral blood mononuclear cells) and THP-1 cells (human monocyte cell line) [110].
T172 4388-4550 Sentence denotes The impaired inflammasome activation is attributed to reduced ROS production via NOX, while H2O2 stimulates inflammasome activation in G6PD-knockdown THP-1 cells.
T173 4551-4842 Sentence denotes This results in weaken bactericidal activity against Staphylococcus aureus and Escherichia coli in G6PD-knockdown THP-1 cells, indicating that G6PD is required for the maintenance of the innate immune response, inflammasome activation, and pathogen clearance through redox homeostasis [110].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T27 894-911 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T28 913-919 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T29 921-925 Phenotype denotes COPD http://purl.obolibrary.org/obo/HP_0006510
T30 948-957 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T31 1041-1057 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T32 2129-2141 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T33 2159-2169 Phenotype denotes vasculitis http://purl.obolibrary.org/obo/HP_0002633
T34 2219-2235 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T35 3463-3472 Phenotype denotes hepatitis http://purl.obolibrary.org/obo/HP_0012115
T36 3840-3854 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T37 4120-4134 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041