PMC:7799377 / 34938-36418 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7799377","sourcedb":"PMC","sourceid":"7799377","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7799377","text":"Parkinson’s disease (PD) and movement disorders\nThe etiology of PD likely involves the interplay of genetic and environmental factors, but viruses have been implicated in causing parkinsonism and other movement disorders [109,110]. In a study using the cerebrospinal fluid of 67 patients (20 with PD, 29 without PD but with another neurological disorder, and 18 healthy controls), the PD patients had a significantly higher mean cerebrospinal fluid antibody response to two specific coronaviruses (MHV-JHM and MHV-A59) than controls or patients with other neurological disorders. It was theorized that some strain of coronavirus might contribute over the long term to the development of PD [110]. This may relate to the epidemiological observation that people who live on farms or grow up in farming communities have a higher risk of developing PD than others, possible due to zoonotic transmission of coronaviruses [111,112].\nThere is no compelling evidence to suggest that patients with PD are more likely to contract COVID-19 or that they are at elevated risk for worse COVID-19 outcomes [113]. However, PD is associated with decreased respiratory function, which might contribute to respiratory distress in any number of infections, including COVID-19 [114]. Furthermore, PD is comorbid with a number of disorders, including cerebrovascular disease, heart failure, and coronary artery disease, any of which would elevate risk of worse outcomes if COVID-19 was contracted 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