PMC:7797414 / 1012-3530 JSONTXT

{"project":"OGERtesthhaider5","denotations":[{"id":"T111","span":{"begin":1019,"end":1025},"obj":"D001249"},{"id":"T112","span":{"begin":1027,"end":1044},"obj":"D003876"},{"id":"T113","span":{"begin":1027,"end":1044},"obj":"D003876"},{"id":"T116","span":{"begin":1049,"end":1066},"obj":"D065631"},{"id":"T117","span":{"begin":1049,"end":1066},"obj":"D065631"},{"id":"T120","span":{"begin":1139,"end":1146},"obj":"D004417"},{"id":"T121","span":{"begin":1139,"end":1146},"obj":"D004417"},{"id":"T66","span":{"begin":26,"end":30},"obj":"UBERON:0002048"},{"id":"T67","span":{"begin":26,"end":39},"obj":"D008171"},{"id":"T68","span":{"begin":26,"end":39},"obj":"D008171"},{"id":"T69","span":{"begin":49,"end":53},"obj":"UBERON:0002048"},{"id":"T71","span":{"begin":150,"end":165},"obj":"UBERON:0008946"},{"id":"T73","span":{"begin":180,"end":212},"obj":"D014890"},{"id":"T74","span":{"begin":180,"end":212},"obj":"D014890"},{"id":"T75","span":{"begin":262,"end":266},"obj":"UBERON:0002048"},{"id":"T76","span":{"begin":262,"end":274},"obj":"D008171"},{"id":"T77","span":{"begin":262,"end":274},"obj":"D008171"},{"id":"T80","span":{"begin":315,"end":337},"obj":"D011657"},{"id":"T81","span":{"begin":315,"end":337},"obj":"D011657"},{"id":"T84","span":{"begin":339,"end":342},"obj":"Q9EQN5"},{"id":"T85","span":{"begin":339,"end":342},"obj":"P09230"},{"id":"T86","span":{"begin":353,"end":375},"obj":"D011657"},{"id":"T87","span":{"begin":353,"end":375},"obj":"D011657"},{"id":"T90","span":{"begin":381,"end":398},"obj":"D011657"},{"id":"T91","span":{"begin":381,"end":398},"obj":"D011657"},{"id":"T92","span":{"begin":424,"end":428},"obj":"UBERON:0002048"},{"id":"T93","span":{"begin":443,"end":447},"obj":"UBERON:0002048"},{"id":"T94","span":{"begin":443,"end":456},"obj":"D008171"},{"id":"T95","span":{"begin":443,"end":456},"obj":"D008171"},{"id":"T96","span":{"begin":561,"end":583},"obj":"D011657"},{"id":"T97","span":{"begin":561,"end":583},"obj":"D011657"},{"id":"T100","span":{"begin":675,"end":679},"obj":"UBERON:0002048"},{"id":"T101","span":{"begin":675,"end":687},"obj":"D008171"},{"id":"T102","span":{"begin":675,"end":687},"obj":"D008171"},{"id":"T105","span":{"begin":756,"end":778},"obj":"D011657"},{"id":"T106","span":{"begin":756,"end":778},"obj":"D011657"},{"id":"T109","span":{"begin":911,"end":917},"obj":"UBERON:0007023"},{"id":"T110","span":{"begin":1019,"end":1025},"obj":"D001249"},{"id":"T122","span":{"begin":1148,"end":1153},"obj":"D003371"},{"id":"T123","span":{"begin":1148,"end":1153},"obj":"D003371"},{"id":"T124","span":{"begin":1162,"end":1168},"obj":"D023341"},{"id":"T125","span":{"begin":1162,"end":1168},"obj":"D023341"},{"id":"T126","span":{"begin":1174,"end":1179},"obj":"UBERON:0001443"},{"id":"T127","span":{"begin":1174,"end":1184},"obj":"D002637"},{"id":"T128","span":{"begin":1174,"end":1184},"obj":"D002637"},{"id":"T129","span":{"begin":1180,"end":1184},"obj":"PR:Q9W0Y6"},{"id":"T130","span":{"begin":1225,"end":1244},"obj":"D012131"},{"id":"T131","span":{"begin":1225,"end":1244},"obj":"D012131"},{"id":"T132","span":{"begin":1301,"end":1305},"obj":"UBERON:0002048"},{"id":"T133","span":{"begin":1339,"end":1344},"obj":"CHEBI:131189"},{"id":"T134","span":{"begin":1405,"end":1409},"obj":"UBERON:0002048"},{"id":"T135","span":{"begin":1478,"end":1487},"obj":"SO:0000993"},{"id":"T136","span":{"begin":1520,"end":1523},"obj":"Q9EQN5"},{"id":"T137","span":{"begin":1520,"end":1523},"obj":"P09230"},{"id":"T138","span":{"begin":1557,"end":1575},"obj":"D012816"},{"id":"T139","span":{"begin":1557,"end":1575},"obj":"D012816"},{"id":"T140","span":{"begin":1587,"end":1599},"obj":"D004802"},{"id":"T141","span":{"begin":1587,"end":1599},"obj":"D004802"},{"id":"T143","span":{"begin":1667,"end":1682},"obj":"UBERON:0008946"},{"id":"T145","span":{"begin":1691,"end":1695},"obj":"UBERON:0002048"},{"id":"T146","span":{"begin":1801,"end":1804},"obj":"Q9EQN5"},{"id":"T147","span":{"begin":1801,"end":1804},"obj":"P09230"},{"id":"T148","span":{"begin":1943,"end":1957},"obj":"CHEBI:50858"},{"id":"T149","span":{"begin":2080,"end":2085},"obj":"CHEBI:23888"},{"id":"T150","span":{"begin":2144,"end":2147},"obj":"Q9EQN5"},{"id":"T151","span":{"begin":2144,"end":2147},"obj":"P09230"},{"id":"T152","span":{"begin":2204,"end":2208},"obj":"CHEBI:23888"},{"id":"T153","span":{"begin":2217,"end":2220},"obj":"Q9EQN5"},{"id":"T154","span":{"begin":2217,"end":2220},"obj":"P09230"},{"id":"T156","span":{"begin":2281,"end":2291},"obj":"52582"},{"id":"T155","span":{"begin":2281,"end":2291},"obj":"D019804"},{"id":"T157","span":{"begin":2281,"end":2291},"obj":"D019804"},{"id":"T158","span":{"begin":2281,"end":2291},"obj":"CHEBI:6775"},{"id":"T160","span":{"begin":2297,"end":2307},"obj":"22299"},{"id":"T159","span":{"begin":2297,"end":2307},"obj":"D017576"},{"id":"T161","span":{"begin":2297,"end":2307},"obj":"CHEBI:600103"},{"id":"T162","span":{"begin":2297,"end":2307},"obj":"D017576"},{"id":"T163","span":{"begin":2316,"end":2319},"obj":"Q9EQN5"},{"id":"T164","span":{"begin":2316,"end":2319},"obj":"P09230"},{"id":"T168","span":{"begin":2355,"end":2366},"obj":"39786"},{"id":"T165","span":{"begin":2355,"end":2366},"obj":"D000069470"},{"id":"T166","span":{"begin":2355,"end":2366},"obj":"D000069470"},{"id":"T167","span":{"begin":2355,"end":2366},"obj":"CHEBI:9943"},{"id":"T170","span":{"begin":2396,"end":2406},"obj":"32937"},{"id":"T169","span":{"begin":2396,"end":2406},"obj":"D017374"},{"id":"T171","span":{"begin":2396,"end":2406},"obj":"CHEBI:7936"},{"id":"T172","span":{"begin":2396,"end":2406},"obj":"D017374"},{"id":"T174","span":{"begin":2409,"end":2419},"obj":"72625"},{"id":"T173","span":{"begin":2409,"end":2419},"obj":"CHEBI:36796"},{"id":"T175","span":{"begin":2409,"end":2419},"obj":"D000068736"},{"id":"T176","span":{"begin":2409,"end":2419},"obj":"D000068736"},{"id":"T177","span":{"begin":2426,"end":2436},"obj":"36437"},{"id":"T178","span":{"begin":2426,"end":2436},"obj":"D020280"},{"id":"T179","span":{"begin":2426,"end":2436},"obj":"CHEBI:9123"},{"id":"T180","span":{"begin":2426,"end":2436},"obj":"D020280"},{"id":"T181","span":{"begin":2445,"end":2448},"obj":"Q9EQN5"},{"id":"T182","span":{"begin":2445,"end":2448},"obj":"P09230"},{"id":"T183","span":{"begin":2495,"end":2505},"obj":"36437"},{"id":"T184","span":{"begin":2495,"end":2505},"obj":"D020280"},{"id":"T185","span":{"begin":2495,"end":2505},"obj":"CHEBI:9123"},{"id":"T186","span":{"begin":2495,"end":2505},"obj":"D020280"},{"id":"T187","span":{"begin":2514,"end":2517},"obj":"Q9EQN5"},{"id":"T188","span":{"begin":2514,"end":2517},"obj":"P09230"}],"text":"Introduction\nEosinophilic lung diseases are rare lung conditions which are characterized by accumulation of eosinophils in the alveolar space and the lung parenchyma. Eosinophilic granulomatosis with polyangiitis and hyper-eosinophilic syndrome are eosinophilic lung disease with systemic involvement whereas acute eosinophilic pneumonia (AEP), chronic eosinophilic pneumonia, and Loeffler syndrome tend to involve only the lung. Eosinophilic lung diseases can be primary or secondary depending on the absence or presence of a known causative factor [1].\nAcute eosinophilic pneumonia was first described in 1989 by Allen and Davis who reported a case series of an idiopathic lung disease characterized by febrile illness, diffuse pulmonary infiltrate, and pulmonary eosinophilia [2]. The epidemiology of this condition remains understudied because of its rarity. It typically occurs in previously healthy young adults and predominantly in males. There are no studies showing relation with other allergic condition like asthma, atopic dermatitis, or allergic rhinitis. However, it is common in smokers [3]. Common clinical symptoms include dyspnea, cough, fever, chills, and chest pain which can result in rapidly progressive respiratory failure, sometimes requiring mechanical ventilation. CT scan of lung typically shows bilateral ground glass opacities. These opacities are usually present in the upper lung zones and they tend to migrate in 25% of patients [4]. There are no consensus guidelines for the diagnosis of AEP. Diagnosis is made by supportive symptoms and signs along with eosinophilia (≥25%) in bronchoalveolar lavage or infiltration of eosinophils in lung parenchyma seen on lung biopsy. The duration of illness from the onset of symptoms is typically less than a month. Most cases of AEP are idiopathic. Identification of causative factors is very important for successful treatment. Avoidance of causative factors along with corticosteroid is very effective in treatment and usually results in complete recovery.\nSeveral case reports have identified a number of drugs and environmental factors as possible causes of secondary AEP. A metanalysis by Bartal et al. documented 228 cases of drug-induced AEP reported between 1990 and 2017. There were 32 cases each of mesalamine- and daptomycin-induced AEP. They also reported three cases of venlafaxine-induced and one case each of paroxetine-, duloxetine-, and sertraline-induced AEP [5]. In this case report we present a case of sertraline-induced AEP."}