> top > docs > PMC:7796072 > spans > 5740-9301 > annotations

PMC:7796072 / 5740-9301 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
192 422-425 Gene denotes HbE Gene:3046
193 2790-2793 Gene denotes HbE Gene:3046
194 2358-2361 Gene denotes HbE Gene:3046
195 1922-1925 Gene denotes HbE Gene:3046
196 1519-1522 Gene denotes HbE Gene:3046
197 1416-1419 Gene denotes HbE Gene:3046
198 1208-1211 Gene denotes HbE Gene:3046
199 934-937 Gene denotes HbE Gene:3046
200 878-881 Gene denotes HbE Gene:3046
201 565-568 Gene denotes HbE Gene:3046
202 125-128 Gene denotes HbE Gene:3046
203 2091-2099 Species denotes patients Tax:9606
204 2159-2164 Species denotes human Tax:9606
205 2165-2177 Species denotes dengue virus Tax:12637
206 2183-2205 Species denotes human coronavirus 229E Tax:11137
207 2482-2490 Species denotes patients Tax:9606
208 129-140 Disease denotes thalassemia MESH:D013789
209 216-224 Disease denotes COVID-19 MESH:C000657245
210 225-235 Disease denotes infections MESH:D007239
211 267-275 Disease denotes COVID-19 MESH:C000657245
212 276-286 Disease denotes infections MESH:D007239
213 636-654 Disease denotes COVID19 infections MESH:C000657245
214 729-737 Disease denotes COVID-19 MESH:C000657245
215 738-744 Disease denotes deaths MESH:D003643
216 770-781 Disease denotes thalassemia MESH:D013789
217 845-856 Disease denotes thalassemia MESH:D013789
218 1019-1032 Disease denotes low infection MESH:D007239
219 1037-1042 Disease denotes death MESH:D003643
220 1150-1158 Disease denotes COVID-19 MESH:C000657245
221 1159-1168 Disease denotes infection MESH:D007239
222 1489-1500 Disease denotes thalassemia MESH:D013789
223 1564-1572 Disease denotes COVID-19 MESH:C000657245
224 1615-1620 Disease denotes death MESH:D003643
225 1926-1937 Disease denotes thalassemia MESH:D013789
226 1971-2022 Disease denotes glucose-6-phosphate dehydrogenase (G6PD) deficiency MESH:D005955
227 2076-2090 Disease denotes G6PD-deficient MESH:D005955
228 2206-2215 Disease denotes infection MESH:D007239
229 2250-2259 Disease denotes pneumonia MESH:D011014
230 2276-2285 Disease denotes infection MESH:D007239
231 2635-2643 Disease denotes COVID-19 MESH:C000657245
232 2676-2683 Disease denotes SE Asia MESH:D008133
233 2749-2757 Disease denotes COVID-19 MESH:C000657245
234 2758-2767 Disease denotes infection MESH:D007239
235 2772-2777 Disease denotes death MESH:D003643
236 2794-2805 Disease denotes thalassemia MESH:D013789
237 2900-2908 Disease denotes COVID-19 MESH:C000657245
238 2997-3015 Disease denotes hemoglobinopathies MESH:D006453
239 3066-3074 Disease denotes COVID-19 MESH:C000657245
240 3082-3093 Disease denotes thalassemia MESH:D013789
241 3139-3150 Disease denotes thalassemia MESH:D013789
242 3195-3203 Disease denotes COVID-19 MESH:C000657245
243 3460-3468 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 2250-2259 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T44 0-260 Sentence denotes Intriguing epidemiological observations suggest, and biological evidence supports, an inverse correlation between increasing HbE/thalassemia trait prevalence rates and decreased susceptibility to, and fatality from, COVID-19 infections (Table 1, Figures 1, 2).
T45 261-503 Sentence denotes Local COVID-19 infections within Thailand vary 6-fold between the northeast (2.84% of total cases) versus the south (19%), in tandem with regional variations in HbE gene frequency (70% in the northeast compared to 12% in the south) [3,13,25].
T46 504-680 Sentence denotes Similarly, Malaysia, which borders southern Thailand, has an HbE trait frequency of only 3.8% [26] but reports substantially higher COVID19 infections compared to Thailand [4].
T47 681-921 Sentence denotes Interestingly, in Cambodia and Laos (where zero COVID-19 deaths are reported) (Table 1), thalassemia mutation rates are similar to Thailand [13]; for Cambodia, the thalassemia prevalence is 62.7% (HbE being the most prevalent, at 56%) [27].
T48 922-1078 Sentence denotes In Myanmar (HbE carrier rates vary between 1.9 and 42% depending on ethnic group and geography), low infection and death rates are also seen (Table 1) [28].
T49 1079-1287 Sentence denotes Vietnam and the neighboring Chinese province of Yunnan both report low COVID-19 infection rates, with locally high prevalence of HbE trait in line with other mainland SE Asian nations (Table 1) [15–24,29–31].
T50 1288-1451 Sentence denotes In Vietnam, the Mon-Khmer-speaking ethnic groups are genetically closer to the Thai-Lao-Cambodian border populations and report HbE gene prevalence up to 36% [29].
T51 1452-1645 Sentence denotes Singapore, where the prevalence of β-thalassemia trait is 0.9% and HbE trait is 0.55% [32], was severely hit by COVID-19 compared to neighboring Thailand, but the death rates were very low [4].
T52 1646-1830 Sentence denotes The high number of cases in Singapore seems to stem from clusters in male migrant workers living in close proximity in crowded living quarters, promoting higher infectious spread [33].
T53 1831-2075 Sentence denotes These migrant workers are from various ethnic groups (e.g., Bengali and Tamil) with higher HbE/thalassemia trait prevalence but also higher glucose-6-phosphate dehydrogenase (G6PD) deficiency rates, compared to resident Singaporeans [32,34,35].
T54 2076-2216 Sentence denotes G6PD-deficient patients have been shown to be highly susceptible to enteroviruses, human dengue virus, and human coronavirus 229E infection.
T55 2217-2291 Sentence denotes They also tend to develop severe pneumonia after microbial infection [36].
T56 2292-2520 Sentence denotes Consequently, close proximity overrides the protective effects of HbE and/or selectively potentiates the risk to infect the ones without the hypothetically protective trait, especially from patients carrying a higher viral load.
T57 2521-2655 Sentence denotes Thailand’s and Singapore’s effective 14-day quarantine policy of all arrivals have now virtually eradicated local COVID-19 cases [37].
T58 2656-2862 Sentence denotes In the remainder of SE Asia and South Asian territories, the trend continues with increasing COVID-19 infection and death rates where HbE/thalassemia trait prevalence is low (Table 1, Figures 1, 2) [14–23].
T59 2863-3021 Sentence denotes In Brazil, a country severely hit by COVID-19, despite heavy early Italian migrations, less than 2% of Brazilian blood donors exhibit hemoglobinopathies [38].
T60 3022-3119 Sentence denotes Similarly, Spain, also severely affected by COVID-19, has a thalassemia trait of only 0.92% [39].
T61 3120-3309 Sentence denotes Despite its higher thalassemia trait prevalence, Italy was severely hit by COVID-19, initially in Lombardy, with a traditionally low carrier rate compared to islands and coastal areas [40].
T62 3310-3561 Sentence denotes Greece [40] and Cyprus [41], with an effective lock-down, a distancing strategy, and a higher, homogenous carrier rate, seem to be experiencing lower COVID-19 rates compared to their European peers, even during the second wave (Table 1, Figures 1, 2).