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PMC:7796072 / 14246-15175
Annnotations
LitCovid-PubTator
{"project":"LitCovid-PubTator","denotations":[{"id":"389","span":{"begin":339,"end":342},"obj":"Gene"},{"id":"390","span":{"begin":479,"end":483},"obj":"Gene"},{"id":"391","span":{"begin":488,"end":503},"obj":"Gene"},{"id":"392","span":{"begin":728,"end":733},"obj":"Gene"},{"id":"393","span":{"begin":734,"end":738},"obj":"Gene"},{"id":"394","span":{"begin":233,"end":241},"obj":"Species"},{"id":"395","span":{"begin":203,"end":211},"obj":"Disease"},{"id":"396","span":{"begin":217,"end":225},"obj":"Disease"},{"id":"397","span":{"begin":304,"end":322},"obj":"Disease"},{"id":"398","span":{"begin":374,"end":382},"obj":"Disease"},{"id":"399","span":{"begin":562,"end":579},"obj":"Disease"}],"attributes":[{"id":"A389","pred":"tao:has_database_id","subj":"389","obj":"Gene:3046"},{"id":"A390","pred":"tao:has_database_id","subj":"390","obj":"Gene:2539"},{"id":"A391","pred":"tao:has_database_id","subj":"391","obj":"Gene:28"},{"id":"A392","pred":"tao:has_database_id","subj":"392","obj":"Gene:571"},{"id":"A393","pred":"tao:has_database_id","subj":"393","obj":"Gene:3162"},{"id":"A394","pred":"tao:has_database_id","subj":"394","obj":"Tax:9606"},{"id":"A395","pred":"tao:has_database_id","subj":"395","obj":"MESH:D007239"},{"id":"A396","pred":"tao:has_database_id","subj":"396","obj":"MESH:C000657245"},{"id":"A397","pred":"tao:has_database_id","subj":"397","obj":"MESH:D013789"},{"id":"A398","pred":"tao:has_database_id","subj":"398","obj":"MESH:D007239"},{"id":"A399","pred":"tao:has_database_id","subj":"399","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We are not claiming causality at this stage but are hypothesizing an interesting association that needs to be tested with regard to causality. Simple hemoglobin electrophoresis of the approximately 4000 infected Thai COVID-19 cohort patients as a case control study will reveal whether the prevalence of thalassemia traits in general (and HbE in particular) differs between infected and uninfected populations. Advanced molecular analyses can be performed on the affected cases. G6PD and ABO blood group analyses could also be performed to elucidate whether the COVID-19-infected cohort has a higher representation of these genetic determinants. Furthermore, miRNA analyses and genetic polymorphism and molecular studies of the BACH1/HO-1 pathway and interferons would elucidate the mechanism of resistance and eventually lead to novel treatment modalities via miRNA decoys or miRNA mimetics or interferon administration [46,51]."}
LitCovid-sentences
{"project":"LitCovid-sentences","denotations":[{"id":"T91","span":{"begin":0,"end":142},"obj":"Sentence"},{"id":"T92","span":{"begin":143,"end":410},"obj":"Sentence"},{"id":"T93","span":{"begin":411,"end":478},"obj":"Sentence"},{"id":"T94","span":{"begin":479,"end":645},"obj":"Sentence"},{"id":"T95","span":{"begin":646,"end":929},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We are not claiming causality at this stage but are hypothesizing an interesting association that needs to be tested with regard to causality. Simple hemoglobin electrophoresis of the approximately 4000 infected Thai COVID-19 cohort patients as a case control study will reveal whether the prevalence of thalassemia traits in general (and HbE in particular) differs between infected and uninfected populations. Advanced molecular analyses can be performed on the affected cases. G6PD and ABO blood group analyses could also be performed to elucidate whether the COVID-19-infected cohort has a higher representation of these genetic determinants. Furthermore, miRNA analyses and genetic polymorphism and molecular studies of the BACH1/HO-1 pathway and interferons would elucidate the mechanism of resistance and eventually lead to novel treatment modalities via miRNA decoys or miRNA mimetics or interferon administration [46,51]."}