PMC:7796052 / 9356-10241 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
267	0-10	Gene	denotes	Bradykinin	Gene:3827
268	32-43	Gene	denotes	B2 receptor	Gene:624
269	194-198	Gene	denotes	IL-6	Gene:3569
270	203-207	Gene	denotes	IL-8	Gene:3576
271	221-225	Gene	denotes	MAPK	Gene:5594
272	226-230	Gene	denotes	AP-1	Gene:3726
273	532-536	Gene	denotes	IL-6	Gene:3569
274	474-476	Gene	denotes	BK	Gene:3827
275	147-149	Gene	denotes	BK	Gene:3827
276	665-670	Species	denotes	women	Tax:9606
277	386-396	Chemical	denotes	raloxifene	MESH:D020849
278	741-751	Chemical	denotes	raloxifene	MESH:D020849
279	90-101	Disease	denotes	hypotensive	MESH:D007022
280	267-278	Disease	denotes	hypotensive	MESH:D007022
281	686-708	Disease	denotes	cardiovascular disease	MESH:D002318

Id	Subject	Object	Predicate	Lexical cue	hp_id
T14	686-708	Phenotype	denotes	cardiovascular disease	http://purl.obolibrary.org/obo/HP_0001626

Id	Subject	Object	Predicate	Lexical cue
T62	0-114	Sentence	denotes	Bradykinin signaling though the B2 receptor induces a proinflammatory action as well as a hypotensive effect [33].
T63	115-347	Sentence	denotes	The proinflammatory activity of BK involves the stimulation of cytokines, like IL-6 and IL-8, through the MAPK/AP-1 signaling axis [17,34], whereas the hypotensive effects are due to vasodilation and increased vascular permeability.
T64	348-537	Sentence	denotes	Due to the partial agonist profile of raloxifene, it is expected that the compound antagonizes the proinflammatory effects of BK, modulating the levels of diverse cytokines, including IL-6.
T65	538-885	Sentence	denotes	To support this hypothesis, in clinical trials aimed at understanding the effect of hormone replacement therapy for menopausal women on the risk of cardiovascular disease, in contrast to other compounds raloxifene did not exhibit a proinflammatory profile [35,36] that could, in part, be explained by its antagonistic effect on the BK B2 receptor.