PMC:7796052 / 7114-7471 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"207","span":{"begin":321,"end":323},"obj":"Gene"},{"id":"209","span":{"begin":277,"end":279},"obj":"Gene"},{"id":"210","span":{"begin":52,"end":54},"obj":"Gene"},{"id":"211","span":{"begin":29,"end":39},"obj":"Chemical"},{"id":"212","span":{"begin":233,"end":243},"obj":"Chemical"}],"attributes":[{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Gene:3827"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"Gene:3827"},{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"Gene:3827"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D020849"},{"id":"A212","pred":"tao:has_database_id","subj":"212","obj":"MESH:D020849"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As can be seen in Figure 1a, raloxifene antagonizes BK with an IC50 ~16 µM with an apparent dissociation constant KB = 1.8 µM, computed using the modified Cheng Prusoff equation [32]:KB=IC501+AEC50 where, IC50 = 16 µM corresponds to raloxifene and EC50 = 2.4 pM corresponds to BK, and A = 0.03 nM is the concentration of BK that was used in the experiments."}

{"project":"LitCovid-sentences","denotations":[{"id":"T48","span":{"begin":0,"end":357},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As can be seen in Figure 1a, raloxifene antagonizes BK with an IC50 ~16 µM with an apparent dissociation constant KB = 1.8 µM, computed using the modified Cheng Prusoff equation [32]:KB=IC501+AEC50 where, IC50 = 16 µM corresponds to raloxifene and EC50 = 2.4 pM corresponds to BK, and A = 0.03 nM is the concentration of BK that was used in the experiments."}