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PMC:7796052 / 1774-3453 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
94 424-428 Gene denotes IL-6 Gene:3569
95 547-557 Gene denotes bradykinin Gene:3827
96 559-561 Gene denotes BK Gene:3827
97 831-862 Gene denotes angiotensin converting enzyme 2 Gene:59272
98 864-868 Gene denotes ACE2 Gene:59272
99 917-921 Gene denotes ACE2 Gene:59272
100 961-974 Gene denotes angiotensin I Gene:183
101 992-1021 Gene denotes angiotensin-converting enzyme Gene:1636
102 1023-1026 Gene denotes ACE Gene:1636
103 1188-1192 Gene denotes ACE2 Gene:59272
104 1297-1301 Gene denotes IL-6 Gene:3569
105 1378-1380 Gene denotes BK Gene:3827
106 1573-1575 Gene denotes BK Gene:3827
107 746-748 Gene denotes BK Gene:3827
108 1232-1234 Gene denotes BK Gene:3827
109 777-779 Gene denotes BK Gene:3827
110 628-636 Species denotes patients Tax:9606
111 792-800 Species denotes patients Tax:9606
112 892-902 Species denotes SARS-Cov-2 Tax:2697049
113 1314-1322 Species denotes patients Tax:9606
114 1665-1673 Species denotes patients Tax:9606
115 1623-1629 Chemical denotes oxygen MESH:D010100
116 13-21 Disease denotes Covid-19 MESH:C000657245
117 346-354 Disease denotes Covid-19 MESH:C000657245
118 649-657 Disease denotes Covid-19 MESH:C000657245
119 783-791 Disease denotes Covid-19 MESH:C000657245
120 1305-1313 Disease denotes Covid-19 MESH:C000657245
121 1656-1664 Disease denotes Covid-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 601-615 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T10 1430-1444 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T13 0-233 Sentence denotes Treatment of Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in disease progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing.
T14 234-355 Sentence denotes Indeed, there is a number of ongoing clinical trials to test the efficacy of diverse FDA-approved drugs against Covid-19.
T15 356-502 Sentence denotes Among them, a few involve assessment of the therapeutic efficacy of IL-6 inhibition, unfortunately without reporting conclusive results [9,10,11].
T16 503-672 Sentence denotes Recently, it was proposed that dysregulated bradykinin (BK) signaling could be the trigger of the cytokine storm observed in patients with severe Covid-19 [12,13,14,15].
T17 673-908 Sentence denotes The rational for this hypothesis relies on the increased availability of BK and its metabolite des-Arg9-BK in Covid-19 patients, due to the downregulation of angiotensin converting enzyme 2 (ACE2), the entry protein of SARS-Cov-2 [16].
T18 909-1090 Sentence denotes Indeed, ACE2 downregulation increases the amount of angiotensin I processed by the angiotensin-converting enzyme (ACE) with a concomitant decrease of its degradation activity on BK.
T19 1091-1227 Sentence denotes Moreover, levels of des-Arg9-BK are also increased due to the diminished degradative activity of ACE2 caused by its downregulation [12].
T20 1228-1328 Sentence denotes The BK hypothesis is consistent with the observed elevated levels of IL-6 in Covid-19 patients [17].
T21 1329-1466 Sentence denotes This new perspective suggests that inhibition of BK signaling may be a suitable therapy to avoid the cytokine storm and its consequences.
T22 1467-1679 Sentence denotes Indeed, as a proof of principle, preliminary results from a limited study suggests that inhibition of the BK signaling is associated with a decrease of the oxygen supplementation needed by Covid-19 patients [18].