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PMC:7796052 / 15348-16071 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
397 183-194 Gene denotes B2 receptor Gene:624
398 316-327 Gene denotes B2 receptor Gene:624
399 361-371 Gene denotes bradykinin Gene:3827
400 445-455 Gene denotes bradykinin Gene:3827
401 607-612 Gene denotes GPR30 Gene:2852
402 673-683 Gene denotes bradykinin Gene:3827
403 80-90 Chemical denotes raloxifene MESH:D020849
404 268-278 Chemical denotes raloxifene MESH:D020849
405 484-494 Chemical denotes raloxidene

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T107 0-124 Sentence denotes The aim of the present study was to characterize the pharmacological profile of raloxifene towards the bradykinin receptors.
T108 125-247 Sentence denotes The compound was identified as a micromolar ligand of the B2 receptor by virtual screening in a drug repurposing campaign.
T109 248-423 Sentence denotes Results showed that raloxifene is a weak partial agonist toward the B2 receptor, with a 19% efficacy compared to bradykinin, with an apparent dissociation constant KB ~ 21 µM.
T110 424-640 Sentence denotes The discovery of the bradykinin pharmacodynamics profile of raloxidene explains in part its observed vascular beneficial effects, although they could also be due to activation of the GPR30 receptor signaling pathway.
T111 641-723 Sentence denotes On the other hand, it acts as a bradykinin antagonist for B2 with an IC50 ~ 21 µM.