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PMC:7796052 / 15333-16631 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
397 198-209 Gene denotes B2 receptor Gene:624
398 331-342 Gene denotes B2 receptor Gene:624
399 376-386 Gene denotes bradykinin Gene:3827
400 460-470 Gene denotes bradykinin Gene:3827
401 622-627 Gene denotes GPR30 Gene:2852
402 688-698 Gene denotes bradykinin Gene:3827
403 95-105 Chemical denotes raloxifene MESH:D020849
404 283-293 Chemical denotes raloxifene MESH:D020849
405 499-509 Chemical denotes raloxidene
414 752-762 Gene denotes bradykinin Gene:3827
415 1028-1032 Gene denotes IL-6 Gene:3569
416 1033-1038 Gene denotes STAT3 Gene:6774
417 1116-1125 Species denotes SARS-Cov2 Tax:2697049
418 1265-1273 Species denotes patients Tax:9606
419 980-990 Chemical denotes raloxifene MESH:D020849
420 821-829 Disease denotes Covid-19 MESH:C000657245
421 1256-1264 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T16 796-810 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T105 0-2 Sentence denotes 4.
T106 3-14 Sentence denotes Conclusions
T107 15-139 Sentence denotes The aim of the present study was to characterize the pharmacological profile of raloxifene towards the bradykinin receptors.
T108 140-262 Sentence denotes The compound was identified as a micromolar ligand of the B2 receptor by virtual screening in a drug repurposing campaign.
T109 263-438 Sentence denotes Results showed that raloxifene is a weak partial agonist toward the B2 receptor, with a 19% efficacy compared to bradykinin, with an apparent dissociation constant KB ~ 21 µM.
T110 439-655 Sentence denotes The discovery of the bradykinin pharmacodynamics profile of raloxidene explains in part its observed vascular beneficial effects, although they could also be due to activation of the GPR30 receptor signaling pathway.
T111 656-738 Sentence denotes On the other hand, it acts as a bradykinin antagonist for B2 with an IC50 ~ 21 µM.
T112 739-917 Sentence denotes Based on the bradykinin hypothesis on the trigger of the cytokine storm in severe Covid-19 [12,13,14,15], these results suggest that the compound could be used for its treatment.
T113 918-1173 Sentence denotes Present results support previous claims suggesting the use of raloxifene based on its capacity to inhibit the IL-6/STAT3 signaling pathway [45], and also for being a prospective antiviral agent for SARS-Cov2 as inhibitor of the two-pore channel TCP2 [48].
T114 1174-1298 Sentence denotes Very recently a clinical trial in Italy has been approved to test its efficacy in COVID-19 patients with mild symptoms [50].