PMC:7796052 / 108-939 JSON TXT

Annnotations TAB JSON ListView MergeView

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
14	268-278	Gene	denotes	bradykinin	Gene:3827
15	430-440	Gene	denotes	bradykinin	Gene:3827
16	587-597	Gene	denotes	bradykinin	Gene:3827
17	697-708	Gene	denotes	B2 receptor	Gene:624
18	332-340	Species	denotes	patients	Tax:9606
19	454-464	Chemical	denotes	raloxifene	MESH:D020849
20	568-578	Chemical	denotes	raloxifene	MESH:D020849
21	0-8	Disease	denotes	Covid-19	MESH:C000657245
22	353-361	Disease	denotes	Covid-19	MESH:C000657245
23	809-817	Disease	denotes	Covid-19	MESH:C000657245

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	305-319	Phenotype	denotes	cytokine storm	http://purl.obolibrary.org/obo/HP_0033041

Id	Subject	Object	Predicate	Lexical cue
T3	0-220	Sentence	denotes	Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including drug repurposing.
T4	221-362	Sentence	denotes	Recently, it was suggested that a dysregulated bradykinin signaling can trigger the cytokine storm observed in patients with severe Covid-19.
T5	363-535	Sentence	denotes	In the scope of a drug repurposing campaign undertaken to identify bradykinin antagonists, raloxifene was identified as prospective compound in a virtual screening process.
T6	536-709	Sentence	denotes	The pharmacodynamics profile of raloxifene towards bradykinin receptors is reported in the present work, showing a weak selective partial agonist profile at the B2 receptor.
T7	710-831	Sentence	denotes	In view of this new profile, its possible use as a therapeutical agent for the treatment of severe Covid-19 is discussed.