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PMC:7796041 / 29917-33081 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
871 423-431 Species denotes patients Tax:9606
872 259-269 Disease denotes arrhythmia MESH:D001145
873 305-315 Disease denotes arrhythmic MESH:D001145
874 408-419 Disease denotes arrhythmias MESH:D001145
875 522-533 Disease denotes arrhythmias MESH:D001145
878 1125-1133 Species denotes patients Tax:9606
879 1193-1201 Species denotes patients Tax:9606
891 1905-1913 Species denotes Patients Tax:9606
892 2174-2182 Species denotes patients Tax:9606
893 2715-2723 Species denotes patients Tax:9606
894 3155-3163 Species denotes patients Tax:9606
895 2491-2509 Chemical denotes hydroxochloroquine
896 1895-1903 Disease denotes COVID-19 MESH:C000657245
897 2475-2483 Disease denotes COVID-19 MESH:C000657245
898 2643-2653 Disease denotes arrhythmia MESH:D001145
899 2913-2923 Disease denotes arrhythmia MESH:D001145
900 2951-2959 Disease denotes COVID-19 MESH:C000657245
901 3146-3154 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T207 259-269 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T208 408-419 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T209 522-533 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T210 2643-2653 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T211 2913-2923 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T237 0-11 Sentence denotes Limitations
T238 12-85 Sentence denotes Due to its retrospective design, this study carries inherent limitations.
T239 86-296 Sentence denotes Despite thorough analysis of clinical records and use of different source documents (e.g., discharge notes, nurses’ reports, daily doctors’ documentation) underreporting of arrhythmia events cannot be excluded.
T240 297-394 Sentence denotes Not all arrhythmic events during the clinical course may have been documented in written reports.
T241 395-492 Sentence denotes Asymptomatic arrhythmias in patients without continuous ECG-monitoring may also have been missed.
T242 493-630 Sentence denotes However, clinically relevant arrhythmias leading to medical interventions are documented as part of the participating centers’ standards.
T243 631-751 Sentence denotes Baseline and outcome data recorded in this study were prespecified and screened for in the available clinical documents.
T244 752-829 Sentence denotes Missing parameters were specifically inquired from the participating centers.
T245 830-997 Sentence denotes Due to different admission protocols and diagnostic standards, there are remaining missing values with regard to certain baseline parameters or biomarker measurements.
T246 998-1134 Sentence denotes However, we clearly indicate this limitation in the respective tables whenever information was available only in a subgroup of patients.
T247 1135-1394 Sentence denotes QTc-duration was available at baseline in the majority of patients, however, due to different standards of ECG-based follow-up, QTc-duration in the course of hospitalization, e.g., during therapy with QT-prolonging drugs, could not be systematically analyzed.
T248 1395-1538 Sentence denotes Inclusion of both tertiary and secondary-level hospitals may lead to treatment bias due to different standards of care or available facilities.
T249 1539-1700 Sentence denotes Importantly, in our study, all contributing centers provide intermediate and intensive care units and operate according to national and international guidelines.
T250 1701-1840 Sentence denotes Cardiorespiratory monitoring, non-invasive and mechanical ventilation are carried out according to guidelines in all participating centers.
T251 1841-1904 Sentence denotes All centers treated both moderate and severe cases of COVID-19.
T252 1905-2055 Sentence denotes Patients requiring extracorporeal life support were primarily treated at tertiary centers but constituted a minority of subjects in this study cohort.
T253 2056-2135 Sentence denotes Therefore, we do not expect significant bias due to differences in center size.
T254 2136-2268 Sentence denotes However, due to the limited number of patients in the respective subgroups a comprehensive analysis of this aspect was not feasible.
T255 2269-2408 Sentence denotes In order to provide further insight, we present an overview into the types and individual contribution of participating centers (Table S1).
T256 2409-2551 Sentence denotes Additionally, individual specific therapy attemps with respect to COVID-19, e.g., hydroxochloroquine administration, were specified (Table 1).
T257 2552-2740 Sentence denotes Left ventricular ejection fraction (LVEF) may have constituted an additional predictor for arrhythmia, however, the value was not provided in a relevant number of patients in this cohorts.
T258 2741-2960 Sentence denotes In order to account for this limitation, we attempted imputation of these values (Supplementary Materials) hinting at a potential role of reduced LVEF as a risk factor for arrhythmia during hospitalization for COVID-19.
T259 2961-3081 Sentence denotes However, these results are exploratory and have to be interpreted with caution due to the high number of missing values.
T260 3082-3164 Sentence denotes Further efforts should be made to study this specific aspect in COVID-19 patients.