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PMC:7796041 / 15967-18723 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
431 39-50 Disease denotes Arrhythmias MESH:D001145
452 186-194 Species denotes patients Tax:9606
453 215-223 Species denotes patients Tax:9606
454 290-298 Species denotes Patients Tax:9606
455 456-464 Species denotes patients Tax:9606
456 757-765 Species denotes patients Tax:9606
457 813-821 Species denotes patients Tax:9606
458 1047-1055 Species denotes patients Tax:9606
459 707-725 Chemical denotes hydroxychloroquine MESH:D006886
460 859-871 Chemical denotes azithromycin MESH:D017963
461 1075-1093 Chemical denotes hydroxychloroquine MESH:D006886
462 100-111 Disease denotes arrhythmias MESH:D001145
463 139-147 Disease denotes COVID-19 MESH:C000657245
464 200-210 Disease denotes arrhythmia MESH:D001145
465 232-242 Disease denotes arrhythmia MESH:D001145
466 270-278 Disease denotes COVID-19 MESH:C000657245
467 304-315 Disease denotes arrhythmias MESH:D001145
468 366-378 Disease denotes hypertension MESH:D006973
469 383-405 Disease denotes cardiovascular disease MESH:D002318
470 470-480 Disease denotes arrhythmia MESH:D001145
471 678-686 Disease denotes COVID-19 MESH:C000657245
483 1893-1901 Species denotes patients Tax:9606
484 1211-1233 Disease denotes cardiovascular disease MESH:D002318
485 1238-1250 Disease denotes hypertension MESH:D006973
486 1285-1295 Disease denotes arrhythmia MESH:D001145
487 1452-1474 Disease denotes cardiovascular disease MESH:D002318
488 1530-1540 Disease denotes arrhythmia MESH:D001145
489 1544-1552 Disease denotes COVID-19 MESH:C000657245
490 1576-1588 Disease denotes hypertension MESH:D006973
491 1916-1926 Disease denotes arrhythmia MESH:D001145
492 1959-1969 Disease denotes arrhythmia MESH:D001145
493 2159-2169 Disease denotes arrhythmia MESH:D001145
499 2578-2582 Gene denotes IL-6 Gene:3569
500 2713-2716 Gene denotes CRP Gene:1401
501 2447-2455 Species denotes patients Tax:9606
502 2461-2471 Disease denotes arrhythmia MESH:D001145
503 2616-2626 Disease denotes arrhythmia MESH:D001145

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T103 39-50 Phenotype denotes Arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T104 100-111 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T105 200-210 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T106 232-242 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T107 304-315 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T108 366-378 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T109 383-405 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T110 470-480 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T111 1211-1233 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T112 1238-1250 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T113 1285-1295 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T114 1452-1474 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T115 1530-1540 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T116 1576-1588 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T117 1916-1926 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T118 1959-1969 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T119 2159-2169 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T120 2461-2471 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675
T121 2616-2626 Phenotype denotes arrhythmia http://purl.obolibrary.org/obo/HP_0011675

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T142 0-4 Sentence denotes 3.3.
T143 5-50 Sentence denotes Clinical Predictors for New-Onset Arrhythmias
T144 51-289 Sentence denotes We analyzed predisposing factors associated with arrhythmias during hospitalization for COVID-19 comparing baseline characteristics of patients with arrhythmia and patients without arrhythmia during hospitalization for COVID-19 (Table 1).
T145 290-416 Sentence denotes Patients with arrhythmias were older and more often had been diagnosed with hypertension and cardiovascular disease (Table 1).
T146 417-566 Sentence denotes QTc duration at baseline was longer in patients with arrhythmia, however, median values were within the physiological range in both groups (Table 1).
T147 567-687 Sentence denotes Furthermore, we analyzed the prevalence of potentially proarrhythmic medication administered in the context of COVID-19.
T148 688-790 Sentence denotes In both subgroups, hydroxychloroquine was used in 44.1% and 44.6% of patients, respectively (Table 1).
T149 791-872 Sentence denotes A smaller fraction of patients in both groups additionally received azithromycin.
T150 873-987 Sentence denotes There was no statistically significant difference in the use of QT-prolonging drugs between both groups (Table 1).
T151 988-1109 Sentence denotes Median QTc-duration at baseline was within normal range in patients who later received hydroxychloroquine (409.0 ms; P25:
T152 1110-1124 Sentence denotes 390.5 ms, P75:
T153 1125-1135 Sentence denotes 421.5 ms).
T154 1136-1306 Sentence denotes Regularized logistic regression led to the selection of the variables age, cardiovascular disease and hypertension with respect to the prediction of arrhythmia incidence.
T155 1307-1650 Sentence denotes The subsequently fitted multiple logistic regression model revealed significant association of age (OR 1.036; 95% CI 1.004–1.074; p = 0.036) and cardiovascular disease (OR 3.307; 95% CI 1.329–8.232; p = 0.01) with incident arrhythmia in COVID-19, whereas the effect of hypertension was not significant (OR 2.08; 95% CI 0.794–5.796; p = 0.144).
T156 1651-1741 Sentence denotes As measure of the model’s performance an area under the curve (AUC) value of 0.74 (95% CI:
T157 1742-1830 Sentence denotes 0.65; 0.84) was estimated by applying 5-fold cross-validation (Supplementary Figure S1).
T158 1831-1993 Sentence denotes Left ventricular ejection fraction was documented in 47.1% of patients with incident arrhythmia and only 21.2% of cases without arrhythmia during hospitalization.
T159 1994-2191 Sentence denotes Attempts at imputing LVEF and including the imputed dataset in the final logistic regression model hinted at a potential role of LVEF as an additional predictor for arrhythmia incidence (Table S1).
T160 2192-2347 Sentence denotes However, due to the high number of missing values, LVEF was omitted from the final logistic regression model to ensure reliability of statistical analyses.
T161 2348-2533 Sentence denotes With regard to peak levels of cardiac and inflammatory biomarkers assessed during hospitalization, patients with arrhythmia displayed higher levels of hsTnT and NTproBNP (Figure 3A, B).
T162 2534-2756 Sentence denotes Additionally, a more pronounced increase in IL-6 and LDH could be detected in the arrhythmia subgroup, whereas there was no statistically significant difference in peak levels of CRP between groups (Table 2, Figure 3C, D).