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PMC:7795966 / 80-1847 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
36 301-314 Gene denotes methemoglobin Gene:3048
37 1224-1228 Gene denotes G6PD Gene:2539
38 1354-1358 Gene denotes G6PD Gene:2539
39 1732-1737 Gene denotes MetHb Gene:3048
40 1466-1471 Gene denotes MetHb Gene:3048
41 1029-1034 Gene denotes MetHb Gene:3048
42 937-942 Gene denotes MetHb Gene:3048
43 673-678 Gene denotes MetHb Gene:3048
44 531-536 Gene denotes MetHb Gene:3048
45 316-321 Gene denotes MetHb Gene:3048
46 28-45 Species denotes novel coronavirus Tax:2697049
47 47-57 Species denotes SARS-CoV-2 Tax:2697049
48 219-229 Species denotes SARS-CoV-2 Tax:2697049
49 272-280 Species denotes patients Tax:9606
50 586-594 Species denotes patients Tax:9606
51 975-983 Species denotes patients Tax:9606
52 1125-1133 Species denotes patients Tax:9606
53 1164-1171 Species denotes patient Tax:9606
54 1180-1187 Species denotes patient Tax:9606
55 1509-1517 Species denotes patients Tax:9606
56 1190-1197 Chemical denotes glucose MESH:D005947
57 1414-1432 Chemical denotes hydroxychloroquine MESH:D006886
58 75-84 Disease denotes pneumonia MESH:D011014
59 95-120 Disease denotes Corona Virus Disease 2019 MESH:C000657245
60 122-130 Disease denotes COVID-19 MESH:C000657245
61 203-213 Disease denotes infections MESH:D007239
62 243-251 Disease denotes COVID-19 MESH:C000657245
63 577-585 Disease denotes COVID-19 MESH:C000657245
64 966-974 Disease denotes COVID-19 MESH:C000657245
65 999-1013 Disease denotes critically ill MESH:D016638
66 1298-1341 Disease denotes methemoglobinemia and carboxyhemoglobinemia MESH:D008708
67 1500-1508 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 75-84 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T2 1298-1315 Phenotype denotes methemoglobinemia http://purl.obolibrary.org/obo/HP_0012119

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T4 0-252 Sentence denotes Following the outbreak of a novel coronavirus (SARS-CoV-2) associated with pneumonia in China (Corona Virus Disease 2019, COVID-19) at the end of 2019, the world is currently facing a global pandemic of infections with SARS-CoV-2 and cases of COVID-19.
T5 253-595 Sentence denotes Since severely ill patients often show elevated methemoglobin (MetHb) and carboxyhemoglobin (COHb) concentrations in their blood as a marker of disease severity, we aimed to summarize the currently available published study results (case reports and cross-sectional studies) on MetHb and COHb concentrations in the blood of COVID-19 patients.
T6 596-656 Sentence denotes To this end, a systematic literature research was performed.
T7 657-869 Sentence denotes For the case of MetHb, seven publications were identified (five case reports and two cross-sectional studies), and for the case of COHb, three studies were found (two cross-sectional studies and one case report).
T8 870-1134 Sentence denotes The findings reported in the publications show that an increase in MetHb and COHb can happen in COVID-19 patients, especially in critically ill ones, and that MetHb and COHb can increase to dangerously high levels during the course of the disease in some patients.
T9 1135-1342 Sentence denotes The medications given to the patient and the patient’s glucose-6-phospate dehydrogenase (G6PD) status seem to be important factors determining the severity of the methemoglobinemia and carboxyhemoglobinemia.
T10 1343-1450 Sentence denotes Therefore, G6PD status should be determined before medications such as hydroxychloroquine are administered.
T11 1451-1767 Sentence denotes In conclusion, MetHb and COHb can be elevated in COVID-19 patients and should be checked routinely in order to provide adequate medical treatment as well as to avoid misinterpretation of fingertip pulse oximetry readings, which can be inaccurate and unreliable in case of elevated MetHb and COHb levels in the blood.