PMC:7795966 / 28010-28679
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795966","sourcedb":"PMC","sourceid":"7795966","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795966","text":"Interestingly, while elevated COHb levels seem to be correlated with COVID-19 severity, intensive care mortality from other causes was found to be associated with too low [12,77] and both too low or too high COHb values [11], indicating the existence of an optimal COHb level for optimal physiological functioning [12]. HO-1 upregulation, associated with elevations of COHb, has immunomodulatory and anti-inflammatory effects [78]. Inflammation changes COHb levels in the blood in a complex time-dependent manner as demonstrated by experimental endotoxemia in humans [79], highlighting the non-linear relationship between inflammation, disease severity and COHb levels.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"999","span":{"begin":320,"end":324},"obj":"Gene"},{"id":"1000","span":{"begin":560,"end":566},"obj":"Species"},{"id":"1001","span":{"begin":69,"end":77},"obj":"Disease"},{"id":"1002","span":{"begin":103,"end":112},"obj":"Disease"},{"id":"1003","span":{"begin":432,"end":444},"obj":"Disease"},{"id":"1004","span":{"begin":545,"end":556},"obj":"Disease"},{"id":"1005","span":{"begin":622,"end":634},"obj":"Disease"}],"attributes":[{"id":"A999","pred":"tao:has_database_id","subj":"999","obj":"Gene:3162"},{"id":"A1000","pred":"tao:has_database_id","subj":"1000","obj":"Tax:9606"},{"id":"A1001","pred":"tao:has_database_id","subj":"1001","obj":"MESH:C000657245"},{"id":"A1002","pred":"tao:has_database_id","subj":"1002","obj":"MESH:D003643"},{"id":"A1003","pred":"tao:has_database_id","subj":"1003","obj":"MESH:D007249"},{"id":"A1004","pred":"tao:has_database_id","subj":"1004","obj":"MESH:D019446"},{"id":"A1005","pred":"tao:has_database_id","subj":"1005","obj":"MESH:D007249"},{"subj":"999","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1000","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1001","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1002","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1003","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1004","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1005","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T208","span":{"begin":0,"end":319},"obj":"Sentence"},{"id":"T209","span":{"begin":320,"end":431},"obj":"Sentence"},{"id":"T210","span":{"begin":432,"end":669},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T208","pred":"source","obj":"LitCovid-sentences"},{"subj":"T209","pred":"source","obj":"LitCovid-sentences"},{"subj":"T210","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93ebec","default":true},{"id":"LitCovid-sentences","color":"#ecd393"}]}]}}