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PMC:7795966 / 1849-4617 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
77 206-214 Species denotes patients Tax:9606
78 246-263 Species denotes human coronavirus Tax:694448
79 265-312 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
80 314-324 Species denotes SARS-CoV-2 Tax:2697049
81 364-374 Species denotes SARS-CoV-2 Tax:2697049
82 34-60 Disease denotes acute respiratory syndrome MESH:D012120
83 386-411 Disease denotes Corona Virus Disease 2019 MESH:C000657245
84 413-421 Disease denotes COVID-19 MESH:C000657245
85 567-575 Disease denotes COVID-19 MESH:C000657245
95 636-655 Disease denotes SARS-CoV-2 infected MESH:C000657245
96 785-804 Disease denotes respiratory illness MESH:D012140
97 911-920 Disease denotes pneumonia MESH:D011014
98 926-935 Disease denotes hypoxemia MESH:D000860
99 937-972 Disease denotes acute respiratory distress syndrome MESH:D012128
100 993-1005 Disease denotes inflammation MESH:D007249
101 1015-1024 Disease denotes infection MESH:D007239
102 1196-1205 Disease denotes infection MESH:D007239
103 1210-1215 Disease denotes death MESH:D003643
123 1445-1458 Gene denotes methemoglobin Gene:3048
124 1460-1465 Gene denotes MetHb Gene:3048
125 1719-1724 Gene denotes MetHb Gene:3048
126 1903-1908 Gene denotes MetHb Gene:3048
127 1583-1588 Gene denotes MetHb Gene:3048
128 1514-1519 Gene denotes MetHb Gene:3048
129 1412-1420 Species denotes patients Tax:9606
130 1608-1620 Chemical denotes ferrous iron
131 1622-1626 Chemical denotes Fe2+
132 1680-1691 Chemical denotes ferric iron
133 1693-1697 Chemical denotes Fe3+
134 1704-1715 Chemical denotes ferric iron
135 1743-1749 Chemical denotes oxygen MESH:D010100
136 1751-1753 Chemical denotes O2 MESH:D010100
137 1766-1768 Chemical denotes O2 MESH:D010100
138 1841-1843 Chemical denotes O2 MESH:D010100
139 1947-1949 Chemical denotes O2 MESH:D010100
140 1397-1411 Disease denotes critically ill MESH:D016638
141 1573-1581 Disease denotes COVID-19 MESH:C000657245
154 2512-2517 Gene denotes MetHb Gene:3048
155 1973-1978 Gene denotes MetHb Gene:3048
156 2130-2163 Chemical denotes nicotinamide adenine dinucleotide MESH:D009243
157 2165-2169 Chemical denotes NADH MESH:D009243
158 2269-2278 Chemical denotes ascorbate MESH:D001205
159 2283-2294 Chemical denotes glutathione MESH:D005978
160 2328-2343 Chemical denotes carbon monoxide MESH:D002248
161 2345-2347 Chemical denotes CO MESH:D002248
162 2359-2361 Chemical denotes CO MESH:D002248
163 2371-2375 Chemical denotes heme MESH:D006418
164 2406-2408 Chemical denotes O2 MESH:D010100
165 2448-2450 Chemical denotes O2 MESH:D010100
169 2727-2732 Gene denotes MetHb Gene:3048
170 2745-2753 Species denotes patients Tax:9606
171 2759-2767 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 785-804 Phenotype denotes respiratory illness http://purl.obolibrary.org/obo/HP_0002086
T4 911-920 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T5 926-935 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T6 943-963 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T12 0-2 Sentence denotes 1.
T13 3-15 Sentence denotes Introduction
T14 16-423 Sentence denotes After a series of acute respiratory syndrome cases of unknown cause were reported in December 2019 in Wuhan, Hubei province, China, genome sequencing of lower respiratory tract samples from patients showed the presence of a novel human coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) [1,2] and the disease associated with SARS-CoV-2 was termed Corona Virus Disease 2019 (COVID-19).
T15 424-518 Sentence denotes On 11 March 2020, the World Health Organization (WHO) declared the outbreak a global pandemic.
T16 519-621 Sentence denotes Until now (November 2020), more than 47 million COVID-19 cases have been reported globally by the WHO.
T17 622-1010 Sentence denotes While most of SARS-CoV-2 infected subjects are pauci-symptomatic [3] and about 15% asymptomatic [4], in some individuals the disease can develop to a more serious respiratory illness requiring hospitalization and intensive care treatment when it progresses to a critical illness involving pneumonia with hypoxemia, acute respiratory distress syndrome and severe systemic inflammation [5].
T18 1011-1231 Sentence denotes The infection-fatality rate (IFR) is determined currently to be 0.68% (0.53–0.82%) [6], with a decrease in the number to be expected due to the current increased divergence between the infection and death rates globally.
T19 1232-1393 Sentence denotes The IFR is a function of age, with an IFR of <0.01% for subjects under 25 years of age and a log-linear increase of the IFR for subjects older than 30 years [7].
T20 1394-1582 Sentence denotes As critically ill patients are often found to form methemoglobin (MetHb) [8,9,10] and carboxyhemoglobin (COHb) [11,12], MetHb and COHb formation might also be relevant in case of COVID-19.
T21 1583-1699 Sentence denotes MetHb is formed when the ferrous iron (Fe2+) of the heme group of hemoglobin (Hb) is oxidized to ferric iron (Fe3+).
T22 1700-1755 Sentence denotes The ferric iron of MetHb is unable to bind oxygen (O2).
T23 1756-1885 Sentence denotes Thus, the O2 dissociation curve is left-shifted, making it more difficult to release O2 and to provide proper tissue oxygenation.
T24 1886-1972 Sentence denotes The formation of MetHb also results in less Hb available for O2 binding and transport.
T25 1973-2300 Sentence denotes MetHb is continuously produced under physiological conditions in a limited amount due to auto-oxidation, but it is rapidly converted back to Hb primarily by nicotinamide adenine dinucleotide (NADH)-dependent cytochrome-b5 reductase (also known as MetHb reductase) and to a limited degree also by ascorbate and glutathione [13].
T26 2301-2409 Sentence denotes COHb is formed when Hb and carbon monoxide (CO) interact; CO binds to heme molecules 240 times more than O2.
T27 2410-2474 Sentence denotes The resulting COHb limits the blood’s O2-carrying capacity [14].
T28 2475-2594 Sentence denotes In healthy, non-smoking individuals, MetHb is in the range of 0.67 ± 0.33% [15] and COHb in the range of 0.5–1.5% [16].
T29 2595-2768 Sentence denotes The aim of our study was to summarize the currently available published study results (case reports and cross sectional studies) on MetHb and COHb in patients with COVID-19.