PMC:7795966 / 12996-14323 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"496","span":{"begin":624,"end":629},"obj":"Gene"},{"id":"497","span":{"begin":1133,"end":1138},"obj":"Gene"},{"id":"498","span":{"begin":34,"end":39},"obj":"Gene"},{"id":"499","span":{"begin":1212,"end":1217},"obj":"Gene"},{"id":"500","span":{"begin":483,"end":488},"obj":"Gene"},{"id":"501","span":{"begin":222,"end":227},"obj":"Gene"},{"id":"502","span":{"begin":89,"end":97},"obj":"Species"},{"id":"503","span":{"begin":169,"end":177},"obj":"Species"},{"id":"504","span":{"begin":657,"end":665},"obj":"Species"},{"id":"505","span":{"begin":1016,"end":1024},"obj":"Species"},{"id":"506","span":{"begin":424,"end":436},"obj":"Chemical"},{"id":"507","span":{"begin":441,"end":459},"obj":"Chemical"},{"id":"508","span":{"begin":490,"end":504},"obj":"Chemical"},{"id":"509","span":{"begin":506,"end":519},"obj":"Chemical"},{"id":"510","span":{"begin":524,"end":541},"obj":"Chemical"},{"id":"511","span":{"begin":80,"end":88},"obj":"Disease"},{"id":"512","span":{"begin":123,"end":138},"obj":"Disease"},{"id":"513","span":{"begin":633,"end":647},"obj":"Disease"},{"id":"514","span":{"begin":648,"end":656},"obj":"Disease"},{"id":"515","span":{"begin":842,"end":850},"obj":"Disease"},{"id":"516","span":{"begin":1007,"end":1015},"obj":"Disease"},{"id":"517","span":{"begin":1237,"end":1245},"obj":"Disease"}],"attributes":[{"id":"A496","pred":"tao:has_database_id","subj":"496","obj":"Gene:3048"},{"id":"A497","pred":"tao:has_database_id","subj":"497","obj":"Gene:3048"},{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"Gene:3048"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"Gene:3048"},{"id":"A500","pred":"tao:has_database_id","subj":"500","obj":"Gene:3048"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"Gene:3048"},{"id":"A502","pred":"tao:has_database_id","subj":"502","obj":"Tax:9606"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"Tax:9606"},{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"Tax:9606"},{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"Tax:9606"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"MESH:D017963"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"MESH:D006886"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"MESH:D008751"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"MESH:D001205"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"MESH:D000111"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"MESH:C000657245"},{"id":"A512","pred":"tao:has_database_id","subj":"512","obj":"MESH:D005955"},{"id":"A513","pred":"tao:has_database_id","subj":"513","obj":"MESH:D016638"},{"id":"A514","pred":"tao:has_database_id","subj":"514","obj":"MESH:C000657245"},{"id":"A515","pred":"tao:has_database_id","subj":"515","obj":"MESH:C000657245"},{"id":"A516","pred":"tao:has_database_id","subj":"516","obj":"MESH:C000657245"},{"id":"A517","pred":"tao:has_database_id","subj":"517","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Alamdari et al. [21] investigated MetHb levels in 25 healthy individuals and 25 COVID-19 patients from Iran. Subjects with G6PD deficiency were excluded from the study. Patients showed a statistically significantly higher MetHb concentration in their blood compared to healthy controls (16.4 ± 9.1% vs. 2.5 ± 0.9%). According to the five cases reported in detail in this publication, the medical standard treatment included azithromycin and hydroxychloroquine. To treat the elevated MetHb, methylene blue, ascorbic acid and N-acetyl cysteine were administered. The authors concluded that it is crucial to treat the elevated MetHb in critically ill COVID-19 patients. Soltan et al. [19] used an artificial intelligence method and data from 115,394 emergency presentations and 72,310 admissions to a large UK teaching hospital group to predict COVID-19 cases. The data used were routinely collected data typically available within one hour during emergency presentations and admissions to hospital. Data from COVID-19 patients (n = 534) and pre-pandemic controls (n = 114,957) were included in the final analysis. Interestingly, while MetHb was a relevant parameter to be included in the models (see Figure 3a,b), MetHb was similar in the COVID-19 cohort compared to pre-pandemic controls (0.62% (0.4–0.8%) vs. 0.88% (0.6–1.1%))."}

{"project":"LitCovid-sentences","denotations":[{"id":"T113","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T114","span":{"begin":109,"end":168},"obj":"Sentence"},{"id":"T115","span":{"begin":169,"end":315},"obj":"Sentence"},{"id":"T116","span":{"begin":316,"end":460},"obj":"Sentence"},{"id":"T117","span":{"begin":461,"end":560},"obj":"Sentence"},{"id":"T118","span":{"begin":561,"end":666},"obj":"Sentence"},{"id":"T119","span":{"begin":667,"end":857},"obj":"Sentence"},{"id":"T120","span":{"begin":858,"end":996},"obj":"Sentence"},{"id":"T121","span":{"begin":997,"end":1111},"obj":"Sentence"},{"id":"T122","span":{"begin":1112,"end":1327},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Alamdari et al. [21] investigated MetHb levels in 25 healthy individuals and 25 COVID-19 patients from Iran. Subjects with G6PD deficiency were excluded from the study. Patients showed a statistically significantly higher MetHb concentration in their blood compared to healthy controls (16.4 ± 9.1% vs. 2.5 ± 0.9%). According to the five cases reported in detail in this publication, the medical standard treatment included azithromycin and hydroxychloroquine. To treat the elevated MetHb, methylene blue, ascorbic acid and N-acetyl cysteine were administered. The authors concluded that it is crucial to treat the elevated MetHb in critically ill COVID-19 patients. Soltan et al. [19] used an artificial intelligence method and data from 115,394 emergency presentations and 72,310 admissions to a large UK teaching hospital group to predict COVID-19 cases. The data used were routinely collected data typically available within one hour during emergency presentations and admissions to hospital. Data from COVID-19 patients (n = 534) and pre-pandemic controls (n = 114,957) were included in the final analysis. Interestingly, while MetHb was a relevant parameter to be included in the models (see Figure 3a,b), MetHb was similar in the COVID-19 cohort compared to pre-pandemic controls (0.62% (0.4–0.8%) vs. 0.88% (0.6–1.1%))."}