PMC:7795888 / 20164-21333 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T47","span":{"begin":300,"end":310},"obj":"Phenotype"},{"id":"T48","span":{"begin":373,"end":382},"obj":"Phenotype"},{"id":"T49","span":{"begin":532,"end":542},"obj":"Phenotype"}],"attributes":[{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0000716"},{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/HP_0012154"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0000716"}],"text":"A growing body of evidence suggests that acute stressors may also adversely affect sensitivity to hedonic stimuli [7]. Similarly, anhedonic symptoms have long been conceptualized in terms of blunted response to positive reinforcement, which in turn represents a biological endophenotype of increased depression vulnerability [37]. Taken together, emotion dysregulation and anhedonia may therefore reflect a more general individual incapacity to regulate adaptive responses when facing stressful events, which may ultimately lead to depression. The findings reported here may have practical implications, as the effect of emotion dysregulation and impaired hedonic tone on depressive symptoms is actionable and modifiable through specific interventions on emotion regulation mechanisms. The emerging fields of emotion research and affective neuroscience have, in fact, paved the way for new potential therapeutic venues [38]. This literature points to mutually inhibitory relationships among neural regions implicated in emotion regulation, and a wide network of cortical areas that are involved in downregulating early reactivity to emotionally salient stimuli [11,39]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T123","span":{"begin":0,"end":118},"obj":"Sentence"},{"id":"T124","span":{"begin":119,"end":330},"obj":"Sentence"},{"id":"T125","span":{"begin":331,"end":543},"obj":"Sentence"},{"id":"T126","span":{"begin":544,"end":785},"obj":"Sentence"},{"id":"T127","span":{"begin":786,"end":924},"obj":"Sentence"},{"id":"T128","span":{"begin":925,"end":1169},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A growing body of evidence suggests that acute stressors may also adversely affect sensitivity to hedonic stimuli [7]. Similarly, anhedonic symptoms have long been conceptualized in terms of blunted response to positive reinforcement, which in turn represents a biological endophenotype of increased depression vulnerability [37]. Taken together, emotion dysregulation and anhedonia may therefore reflect a more general individual incapacity to regulate adaptive responses when facing stressful events, which may ultimately lead to depression. The findings reported here may have practical implications, as the effect of emotion dysregulation and impaired hedonic tone on depressive symptoms is actionable and modifiable through specific interventions on emotion regulation mechanisms. The emerging fields of emotion research and affective neuroscience have, in fact, paved the way for new potential therapeutic venues [38]. This literature points to mutually inhibitory relationships among neural regions implicated in emotion regulation, and a wide network of cortical areas that are involved in downregulating early reactivity to emotionally salient stimuli [11,39]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"274","span":{"begin":300,"end":310},"obj":"Disease"},{"id":"275","span":{"begin":373,"end":382},"obj":"Disease"},{"id":"276","span":{"begin":532,"end":542},"obj":"Disease"},{"id":"277","span":{"begin":672,"end":691},"obj":"Disease"}],"attributes":[{"id":"A274","pred":"tao:has_database_id","subj":"274","obj":"MESH:D000275"},{"id":"A275","pred":"tao:has_database_id","subj":"275","obj":"MESH:D059445"},{"id":"A276","pred":"tao:has_database_id","subj":"276","obj":"MESH:D000275"},{"id":"A277","pred":"tao:has_database_id","subj":"277","obj":"MESH:D000275"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"A growing body of evidence suggests that acute stressors may also adversely affect sensitivity to hedonic stimuli [7]. Similarly, anhedonic symptoms have long been conceptualized in terms of blunted response to positive reinforcement, which in turn represents a biological endophenotype of increased depression vulnerability [37]. Taken together, emotion dysregulation and anhedonia may therefore reflect a more general individual incapacity to regulate adaptive responses when facing stressful events, which may ultimately lead to depression. The findings reported here may have practical implications, as the effect of emotion dysregulation and impaired hedonic tone on depressive symptoms is actionable and modifiable through specific interventions on emotion regulation mechanisms. The emerging fields of emotion research and affective neuroscience have, in fact, paved the way for new potential therapeutic venues [38]. This literature points to mutually inhibitory relationships among neural regions implicated in emotion regulation, and a wide network of cortical areas that are involved in downregulating early reactivity to emotionally salient stimuli [11,39]."}