PMC:7795888 / 18982-20163 JSONTXT

{"project":"LitCovid-PD-HP","denotations":[{"id":"T44","span":{"begin":270,"end":280},"obj":"Phenotype"},{"id":"T45","span":{"begin":516,"end":531},"obj":"Phenotype"},{"id":"T46","span":{"begin":730,"end":740},"obj":"Phenotype"}],"attributes":[{"id":"A44","pred":"hp_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/HP_0000716"},{"id":"A45","pred":"hp_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/HP_0031467"},{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0000716"}],"text":"An important issue pertaining to emotion regulation concerns the interindividual variability in experiencing negative or positive affects, as well as the habitual tendency to prefer some regulatory strategies over others to control distressful affects. On the one hand, depression has long been associated with increased levels of negative and stressful affects [35]. On the other hand, one of the key components of emotion dysregulation is the inability to regulate negative emotion and to decrease the duration of negative affect once it arises [36]. Consistently with this conceptual framework, there is evidence linking impaired emotion regulation mechanisms with depressive symptoms, also at a neurobiological level. Indeed, depression has been repeatedly associated with dysfunction in brain regions that are normally implicated in emotion regulation, including prefrontal cortex, (PFC), amygdala, and hippocampus. Intriguingly, these regions have been implicated in the regulation of stress and coping, with the PFC and the hippocampus providing inhibitory control over stress responses, whereas the amygdala has been implicated in potentiating stress-related behaviors [5]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T117","span":{"begin":0,"end":252},"obj":"Sentence"},{"id":"T118","span":{"begin":253,"end":367},"obj":"Sentence"},{"id":"T119","span":{"begin":368,"end":552},"obj":"Sentence"},{"id":"T120","span":{"begin":553,"end":721},"obj":"Sentence"},{"id":"T121","span":{"begin":722,"end":920},"obj":"Sentence"},{"id":"T122","span":{"begin":921,"end":1181},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"An important issue pertaining to emotion regulation concerns the interindividual variability in experiencing negative or positive affects, as well as the habitual tendency to prefer some regulatory strategies over others to control distressful affects. On the one hand, depression has long been associated with increased levels of negative and stressful affects [35]. On the other hand, one of the key components of emotion dysregulation is the inability to regulate negative emotion and to decrease the duration of negative affect once it arises [36]. Consistently with this conceptual framework, there is evidence linking impaired emotion regulation mechanisms with depressive symptoms, also at a neurobiological level. Indeed, depression has been repeatedly associated with dysfunction in brain regions that are normally implicated in emotion regulation, including prefrontal cortex, (PFC), amygdala, and hippocampus. Intriguingly, these regions have been implicated in the regulation of stress and coping, with the PFC and the hippocampus providing inhibitory control over stress responses, whereas the amygdala has been implicated in potentiating stress-related behaviors [5]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"262","span":{"begin":270,"end":280},"obj":"Disease"},{"id":"263","span":{"begin":445,"end":454},"obj":"Disease"},{"id":"264","span":{"begin":668,"end":687},"obj":"Disease"},{"id":"265","span":{"begin":730,"end":740},"obj":"Disease"},{"id":"266","span":{"begin":777,"end":788},"obj":"Disease"},{"id":"267","span":{"begin":991,"end":997},"obj":"Disease"},{"id":"268","span":{"begin":1077,"end":1083},"obj":"Disease"},{"id":"269","span":{"begin":1152,"end":1158},"obj":"Disease"}],"attributes":[{"id":"A262","pred":"tao:has_database_id","subj":"262","obj":"MESH:D000275"},{"id":"A263","pred":"tao:has_database_id","subj":"263","obj":"MESH:D007319"},{"id":"A264","pred":"tao:has_database_id","subj":"264","obj":"MESH:D000275"},{"id":"A265","pred":"tao:has_database_id","subj":"265","obj":"MESH:D000275"},{"id":"A266","pred":"tao:has_database_id","subj":"266","obj":"MESH:D009461"},{"id":"A267","pred":"tao:has_database_id","subj":"267","obj":"MESH:D000079225"},{"id":"A268","pred":"tao:has_database_id","subj":"268","obj":"MESH:D000079225"},{"id":"A269","pred":"tao:has_database_id","subj":"269","obj":"MESH:D000079225"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"An important issue pertaining to emotion regulation concerns the interindividual variability in experiencing negative or positive affects, as well as the habitual tendency to prefer some regulatory strategies over others to control distressful affects. On the one hand, depression has long been associated with increased levels of negative and stressful affects [35]. On the other hand, one of the key components of emotion dysregulation is the inability to regulate negative emotion and to decrease the duration of negative affect once it arises [36]. Consistently with this conceptual framework, there is evidence linking impaired emotion regulation mechanisms with depressive symptoms, also at a neurobiological level. Indeed, depression has been repeatedly associated with dysfunction in brain regions that are normally implicated in emotion regulation, including prefrontal cortex, (PFC), amygdala, and hippocampus. Intriguingly, these regions have been implicated in the regulation of stress and coping, with the PFC and the hippocampus providing inhibitory control over stress responses, whereas the amygdala has been implicated in potentiating stress-related behaviors [5]."}