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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 1152-1161 Phenotype denotes Anhedonia http://purl.obolibrary.org/obo/HP_0012154
T10 1497-1506 Phenotype denotes anhedonia http://purl.obolibrary.org/obo/HP_0012154
T11 1695-1705 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T12 1738-1748 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T13 1810-1819 Phenotype denotes anhedonia http://purl.obolibrary.org/obo/HP_0012154
T14 1924-1933 Phenotype denotes anhedonia http://purl.obolibrary.org/obo/HP_0012154
T15 2052-2061 Phenotype denotes anhedonia http://purl.obolibrary.org/obo/HP_0012154
T16 2521-2530 Phenotype denotes anhedonia http://purl.obolibrary.org/obo/HP_0012154
T17 3499-3509 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T18 3556-3566 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T19 4884-4894 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716
T20 5122-5132 Phenotype denotes depression http://purl.obolibrary.org/obo/HP_0000716

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T13 0-2 Sentence denotes 1.
T14 3-15 Sentence denotes Introduction
T15 16-116 Sentence denotes The COVID-19 pandemic and the resulting isolation have spiked stress-related symptoms worldwide [1].
T16 117-224 Sentence denotes Italy was the first European Country to face the COVID-19 emergency and to declare a national lockdown [2].
T17 225-409 Sentence denotes On 9 March 2020, the Italian government imposed a national quarantine, restricting the movement of the population except for necessity, special work permissions, and health conditions.
T18 410-619 Sentence denotes Preventive containment measures during the COVID-19 epidemic, including self-isolation and social distancing, had a strong impact on people’s daily life and adversely affected psychological well-being further.
T19 620-766 Sentence denotes Individuals experiencing stress symptoms can feel overwhelmed with emotions and can be at higher risk for developing clinical depressive symptoms.
T20 767-978 Sentence denotes However, only mixed evidence is available for whether inter-individual characteristics and demographics may account for determining the psychological response of a population facing massive stressful events [3].
T21 979-1150 Sentence denotes Hence, as the epidemic continues, enhancing our ability to detect possible predictors of the psychological impact during the COVID-19 outbreak is an important focus point.
T22 1151-1321 Sentence denotes “Anhedonia” is derived from the Greek “a-” (without) “hedone” (pleasure, delight) and is described as the inability to gain pleasure from normally pleasurable activities.
T23 1322-1484 Sentence denotes Pleasure plays a key role in predisposing survival of biological resources and in guaranteeing an essential contribution to the success of adaptive behaviors [4].
T24 1485-1801 Sentence denotes Conversely, anhedonia is an obstacle to achieving evolutionary goals, and it has been considered as a core feature of depressive phenotypes [5], insomuch that Klein proposed the existence of a subtype of major depression, referred to as endogenomorphic depression, marked by characterological anhedonic features [6].
T25 1802-2036 Sentence denotes Indeed, anhedonia is a required symptom for the diagnosis of a major depressive episode, and evidence suggests that trait anhedonia may represent an important prognostic indicator in individuals suffering from affective disorders [7].
T26 2037-2275 Sentence denotes Differences in anhedonia have also been studied on an individual level, suggesting that the subjective hedonic experience originates from brain areas that activate to drive us toward the attainment of primary or secondary human needs [8].
T27 2276-2415 Sentence denotes These regions are part of the so-called brain reward system: amygdala, nucleus accumbens, orbitofrontal cortex (OFC), and cingulate cortex.
T28 2416-2693 Sentence denotes In particular, Zhang et al. [9] suggested that the morphology of the OFC reflects quantitative traits of anhedonia that are continuously distributed throughout the general population and may serve to identify subjects who are at enhanced risk of developing affective disorders.
T29 2694-2971 Sentence denotes Emotional responses are multifaceted phenomena that are associated with bodily symptoms, subjective experiences, cognitive changes, and action tendencies, whereas the hedonic marking of emotions is the quality that distinguishes affects from other psychological processes [10].
T30 2972-3138 Sentence denotes Research on emotion regulation has highlighted that individuals actively respond and often try to modify their affective states rather than passively experience them.
T31 3139-3365 Sentence denotes Indeed, emotion regulation broadly refers to the ability to monitor and evaluate emotional experiences, modulate their intensity or duration, and adaptively manage emotional reactions in order to meet situational demands [11].
T32 3366-3515 Sentence denotes A substantial body of literature suggests the role of emotion dysregulation in accounting for the onset, overlap, and maintenance of depression [12].
T33 3516-3801 Sentence denotes Studies examining emotion regulation in depression have also suggested that depressed individuals exhibit more frequent use of maladaptive strategies, including suppression and rumination, when regulating affects and show difficulties effectively implementing adaptive strategies [13].
T34 3802-3997 Sentence denotes The documented connection between epidemics and mental health sequelae dates back more than 100 years ago, when Menninger associated the 1918 Spanish flu pandemic with psychiatric morbidity [14].
T35 3998-4388 Sentence denotes Over the past few months, a number of studies reported on the prevalence of depressive symptoms among the general population during the COVID-19 pandemic and identified several potential predictive factors, including age, gender, marital status, education level, occupation, loneliness, having an acquaintance infected with COVID-19, as well as past history of medical disorders [15,16,17].
T36 4389-4544 Sentence denotes Conversely, relatively few studies have investigated psychological determinants of depressive symptoms severity during the COVID-19 outbreak [18,19,20,21].
T37 4545-4828 Sentence denotes In light of these observations, we aimed at filling this gap by reporting prevalence of depressive symptoms and distribution patterns of hedonic and emotional dysregulation in a sizeable sample of 500 healthy individuals assessed in the early phase of the COVID-19 outbreak in Italy.
T38 4829-5020 Sentence denotes Further, we sought to identify risk factors predicting depression severity among demographic characteristics, medical and psychopathological variables, and information on lockdown conditions.
T39 5021-5171 Sentence denotes We hypothesized that reduced hedonic capacity and emotional dysregulation might specifically predict depression severity during the COVID-19 pandemic.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
47 543-549 Species denotes people Tax:9606
48 20-28 Disease denotes COVID-19 MESH:C000657245
49 78-84 Disease denotes stress MESH:D000079225
50 166-174 Disease denotes COVID-19 MESH:C000657245
51 453-461 Disease denotes COVID-19 MESH:C000657245
55 645-651 Disease denotes stress MESH:D000079225
56 746-765 Disease denotes depressive symptoms MESH:D000275
57 1104-1112 Disease denotes COVID-19 MESH:C000657245
70 2259-2264 Species denotes human Tax:9606
71 1152-1161 Disease denotes Anhedonia MESH:D059445
72 1257-1266 Disease denotes inability MESH:D007319
73 1497-1506 Disease denotes anhedonia MESH:D059445
74 1603-1613 Disease denotes depressive MESH:D000275
75 1695-1705 Disease denotes depression MESH:D000275
76 1738-1748 Disease denotes depression MESH:D000275
77 1810-1819 Disease denotes anhedonia MESH:D059445
78 1871-1889 Disease denotes depressive episode MESH:D000275
79 1924-1933 Disease denotes anhedonia MESH:D059445
80 2052-2061 Disease denotes anhedonia MESH:D059445
81 2521-2530 Disease denotes anhedonia MESH:D059445
85 3499-3509 Disease denotes depression MESH:D000275
86 3556-3566 Disease denotes depression MESH:D000275
87 3592-3601 Disease denotes depressed MESH:D000275
89 3970-3981 Disease denotes psychiatric MESH:D001523
96 4074-4093 Disease denotes depressive symptoms MESH:D000275
97 4134-4142 Disease denotes COVID-19 MESH:C000657245
98 4308-4316 Disease denotes infected MESH:D007239
99 4322-4330 Disease denotes COVID-19 MESH:C000657245
100 4472-4482 Disease denotes depressive MESH:D000275
101 4512-4520 Disease denotes COVID-19 MESH:C000657245
107 4633-4652 Disease denotes depressive symptoms MESH:D000275
108 4801-4809 Disease denotes COVID-19 MESH:C000657245
109 4884-4894 Disease denotes depression MESH:D000275
110 5122-5132 Disease denotes depression MESH:D000275
111 5153-5161 Disease denotes COVID-19 MESH:C000657245