PMC:7795856 / 700-1126 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"22","span":{"begin":318,"end":322},"obj":"Species"},{"id":"23","span":{"begin":381,"end":390},"obj":"Species"},{"id":"27","span":{"begin":225,"end":228},"obj":"Chemical"},{"id":"28","span":{"begin":229,"end":232},"obj":"Chemical"},{"id":"29","span":{"begin":233,"end":236},"obj":"Chemical"},{"id":"30","span":{"begin":238,"end":241},"obj":"Chemical"},{"id":"35","span":{"begin":406,"end":421},"obj":"Disease"}],"attributes":[{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Tax:10116"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Tax:2005392"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:D011392"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:D000409"},{"id":"A29","pred":"tao:has_database_id","subj":"29","obj":"MESH:D012694"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D007674"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"is of the purified fusion protein indicated the expected composition without any signs of proteolysis. SEC analysis revealed a 10-fold expanded hydrodynamic volume resulting from the fusion with a conformationally disordered Pro/Ala/Ser (PAS) polypeptide of 600 residues. This size effect led to a plasma half-life in rats extended by more than a factor 8 compared to the original synthetic peptide due to retarded kidney filt"}

{"project":"LitCovid-sentences","denotations":[{"id":"T8","span":{"begin":103,"end":271},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"is of the purified fusion protein indicated the expected composition without any signs of proteolysis. SEC analysis revealed a 10-fold expanded hydrodynamic volume resulting from the fusion with a conformationally disordered Pro/Ala/Ser (PAS) polypeptide of 600 residues. This size effect led to a plasma half-life in rats extended by more than a factor 8 compared to the original synthetic peptide due to retarded kidney filt"}