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PMC:7795856 / 22035-23327 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
385 155-160 Gene denotes GLP-1 Gene:2641
386 165-168 Gene denotes GIP Gene:2695
387 177-180 Gene denotes Tα1 Gene:134864
388 185-191 Gene denotes GM-CSF Gene:1437
389 500-503 Gene denotes Tα1 Gene:134864
390 1164-1170 Species denotes yeasts Tax:4932
391 1175-1184 Species denotes mammalian Tax:9606
392 637-646 Species denotes synthetic Tax:2005392
393 322-348 Chemical denotes arginylglycylaspartic acid MESH:C047981
394 550-554 Chemical denotes Gly4 MESH:C046274
395 647-650 Chemical denotes PEG MESH:D011092
396 721-724 Chemical denotes PAS
397 1083-1091 Chemical denotes peptides MESH:D010455
398 428-433 Disease denotes tumor MESH:D009369
399 513-518 Disease denotes tumor MESH:D009369

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T21 428-433 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T22 513-518 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T124 0-72 Sentence denotes Furthermore, PASylation can serve as a linker to join two peptides [69].
T125 73-197 Sentence denotes This is of particular interest if both entities act synergistically, for example, GLP-1 and GIP [70] or Tα1 and GM-CSF [71].
T126 198-463 Sentence denotes Alternatively, the biologically active protein/peptide can be linked via the PAS sequence to a targeting domain such as the arginylglycylaspartic acid peptide RGD peptide which binds to integrins αVβ3 and αVβ5 in order to enhance tumor penetration and accumulation.
T127 464-621 Sentence denotes In fact, fusion of the short-acting Tα1 with the tumor-targeting iRGD peptide using a Gly4 linker has recently demonstrated enhanced antitumor activity [50].
T128 622-794 Sentence denotes In contrast to synthetic PEG linkers, which are commonly used for bioconjugations, the recombinant PAS sequence exhibits a precisely defined size and is biodegradable [72].
T129 795-974 Sentence denotes The PAS polypeptide itself is stable in blood plasma but quickly degraded by intracellular enzymes, thus avoiding organ accumulation [31], a well-known effect for PEGylation [73].
T130 975-1292 Sentence denotes Moreover, PAS sequences are non-immunogenic in animals [31,74] and offer a one-step production of PASylated peptides in various commercially scalable expression systems including bacteria, yeasts, or mammalian cells [35,48], which would even allow the preparation of peptides carrying posttranslational modifications.