PMC:7795856 / 205-858 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
19	443-446	Gene	denotes	Tα1	Gene:134864
21	450-466	Species	denotes	Escherichia coli	Tax:562
24	0-3	Species	denotes	HBV	Tax:10407
25	385-386	Chemical	denotes	N	MESH:D009584
26	402-406	Chemical	denotes	RimJ
31	9-43	Disease	denotes	hepatitis C virus (HCV) infections	MESH:D006526
32	122-130	Disease	denotes	COVID-19	MESH:C000657245
33	131-141	Disease	denotes	infections	MESH:D007239
34	146-152	Disease	denotes	cancer	MESH:D009369

Id	Subject	Object	Predicate	Lexical cue	hp_id
T3	9-18	Phenotype	denotes	hepatitis	http://purl.obolibrary.org/obo/HP_0012115
T4	146-152	Phenotype	denotes	cancer	http://purl.obolibrary.org/obo/HP_0002664

Id	Subject	Object	Predicate	Lexical cue
T5	154-317	Sentence	denotes	Manufacturing of this N-terminally acetylated 28-residue peptide is demanding, and its short plasma half-life limits in vivo efficacy and requires frequent dosing.
T6	318-481	Sentence	denotes	Here, we combined the PASylation technology with enzymatic in situ N-acetylation by RimJ to produce a long-acting version of Tα1 in Escherichia coli at high yield.
T7	482-597	Sentence	denotes	ESI-MS analysis of the purified fusion protein indicated the expected composition without any signs of proteolysis.