PMC:7795856 / 18920-19949 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7795856","sourcedb":"PMC","sourceid":"7795856","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7795856","text":"In comparison with other published approaches to prolong the circulation of Tα1, the measured terminal half-life of Tα1-PAS is even longer than the value of around 8.2 h reported for a corresponding PEGylated peptide after an intravenous injection into the tail vein of Sprague–Dawley rats [55]. This modified Tα1 was prepared by chemically coupling a 5 kDa methoxypolyethylene glycol maleimide via an engineered N-terminal Cys residue. Of note, according to the rules of allometric scaling, a much longer half-life in the range of several days can be expected for Tα1-PAS in humans [56,57], which would allow weekly dosing while achieving a lasting pharmacological effect. According to the prescription information for Zadaxin™ to treat chronic hepatitis B, the recommended dose for the monotherapy, or the combination therapy with interferon, is a 1.6 mg subcutaneous injection twice weekly over 6 months (52 doses). Consequently, weekly or biweekly injections would considerably decrease patient burden and improve compliance.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"324","span":{"begin":76,"end":79},"obj":"Gene"},{"id":"325","span":{"begin":310,"end":313},"obj":"Gene"},{"id":"326","span":{"begin":270,"end":289},"obj":"Species"},{"id":"327","span":{"begin":576,"end":582},"obj":"Species"},{"id":"328","span":{"begin":991,"end":998},"obj":"Species"},{"id":"329","span":{"begin":358,"end":394},"obj":"Chemical"},{"id":"330","span":{"begin":424,"end":427},"obj":"Chemical"},{"id":"331","span":{"begin":746,"end":757},"obj":"Disease"}],"attributes":[{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:50719"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Gene:50719"},{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"Tax:10116"},{"id":"A327","pred":"tao:has_database_id","subj":"327","obj":"Tax:9606"},{"id":"A328","pred":"tao:has_database_id","subj":"328","obj":"Tax:9606"},{"id":"A330","pred":"tao:has_database_id","subj":"330","obj":"MESH:D003545"},{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"MESH:D006509"},{"subj":"324","pred":"source","obj":"LitCovid-PubTator"},{"subj":"325","pred":"source","obj":"LitCovid-PubTator"},{"subj":"326","pred":"source","obj":"LitCovid-PubTator"},{"subj":"327","pred":"source","obj":"LitCovid-PubTator"},{"subj":"328","pred":"source","obj":"LitCovid-PubTator"},{"subj":"329","pred":"source","obj":"LitCovid-PubTator"},{"subj":"330","pred":"source","obj":"LitCovid-PubTator"},{"subj":"331","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T17","span":{"begin":738,"end":755},"obj":"Phenotype"}],"attributes":[{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0200123"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T109","span":{"begin":0,"end":295},"obj":"Sentence"},{"id":"T110","span":{"begin":296,"end":436},"obj":"Sentence"},{"id":"T111","span":{"begin":437,"end":673},"obj":"Sentence"},{"id":"T112","span":{"begin":674,"end":918},"obj":"Sentence"},{"id":"T113","span":{"begin":919,"end":1029},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T109","pred":"source","obj":"LitCovid-sentences"},{"subj":"T110","pred":"source","obj":"LitCovid-sentences"},{"subj":"T111","pred":"source","obj":"LitCovid-sentences"},{"subj":"T112","pred":"source","obj":"LitCovid-sentences"},{"subj":"T113","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#e4ec93","default":true},{"id":"LitCovid-PD-HP","color":"#d993ec"},{"id":"LitCovid-sentences","color":"#93ecbf"}]}]}}