PMC:7787218 / 8639-9698 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	hp_id
T34	103-114	Phenotype	denotes	anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845
T35	238-249	Phenotype	denotes	anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845
T36	311-322	Phenotype	denotes	anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845
T37	524-540	Phenotype	denotes	hypersensitivity	http://purl.obolibrary.org/obo/HP_0041092
T38	750-761	Phenotype	denotes	anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845
T39	883-894	Phenotype	denotes	anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
144	258-265	Species	denotes	patient	Tax:9606
145	353-360	Species	denotes	patient	Tax:9606
146	771-779	Species	denotes	patients	Tax:9606
147	830-840	Species	denotes	SARS-CoV-2	Tax:2697049
148	912-922	Species	denotes	SARS-CoV-2	Tax:2697049
159	98-101	Chemical	denotes	PEG	MESH:D011092
160	161-164	Chemical	denotes	PEG	MESH:D011092
161	173-176	Chemical	denotes	PEG	MESH:D011092
162	283-286	Chemical	denotes	PEG	MESH:D011092
163	572-598	Chemical	denotes	methylprednisolone acetate	MESH:D000077555
164	614-633	Chemical	denotes	medroxyprogesterone	MESH:D008525
165	647-655	Chemical	denotes	PEG 3350	MESH:C000595212
166	681-684	Chemical	denotes	PEG	MESH:D011092
167	977-985	Chemical	denotes	PEG 2000	MESH:C000595210
168	1017-1022	Chemical	denotes	lipid	MESH:D008055
175	524-540	Disease	denotes	hypersensitivity	MESH:D004342

Id	Subject	Object	Predicate	Lexical cue
T32	0-1059	Sentence	denotes	The risk of sensitization appears to be higher with injectable drugs with higher-molecular-weight PEG; anaphylaxis associated with bowel preparations containing PEG 3350 to PEG 4000 has been noted in case reports.9,10 The reports include anaphylaxis after a patient was exposed to a PEG 3350 bowel preparation; anaphylaxis subsequently developed on the patient’s first exposure to a pegylated liposome microbubble, PEGLip 5000 perflutren echocardiography contrast (Definity), which is labeled with a warning about immediate hypersensitivity reactions.11 For drugs such as methylprednisolone acetate and injectable medroxyprogesterone that contain PEG 3350, it now appears that the PEG component is more likely than the active drug to be the cause of anaphylaxis.9,12 For patients with a history of an anaphylactic reaction to the SARS-CoV-2 Pfizer–BioNTech mRNA vaccine, the risk of anaphylaxis with the Moderna SARS-CoV-2 mRNA vaccine — whose delivery system is also based on PEG 2000, but with different respective lipid mixtures (see Table 1) — is unknown.