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PMC:7787218 / 3889-5821 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T17 0-11 Phenotype denotes Anaphylaxis http://purl.obolibrary.org/obo/HP_0100845
T18 551-559 Phenotype denotes flushing http://purl.obolibrary.org/obo/HP_0031284
T19 561-566 Phenotype denotes hives http://purl.obolibrary.org/obo/HP_0001025
T20 568-583 Phenotype denotes laryngeal edema http://purl.obolibrary.org/obo/HP_0012027
T21 585-593 Phenotype denotes wheezing http://purl.obolibrary.org/obo/HP_0030828
T22 595-611 Phenotype denotes nausea, vomiting http://purl.obolibrary.org/obo/HP_0002017
T23 613-624 Phenotype denotes tachycardia http://purl.obolibrary.org/obo/HP_0001649
T24 626-637 Phenotype denotes hypotension http://purl.obolibrary.org/obo/HP_0002615
T25 792-803 Phenotype denotes anaphylaxis http://purl.obolibrary.org/obo/HP_0100845
T26 1198-1209 Phenotype denotes anaphylaxis http://purl.obolibrary.org/obo/HP_0100845
T27 1635-1646 Phenotype denotes anaphylaxis http://purl.obolibrary.org/obo/HP_0100845

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
74 668-676 Species denotes Patients Tax:9606
75 203-214 Chemical denotes epinephrine MESH:D004837
76 474-483 Chemical denotes histamine MESH:D006632
77 496-510 Chemical denotes prostaglandins MESH:D011453
78 516-528 Chemical denotes leukotrienes MESH:D015289
79 990-1001 Chemical denotes epinephrine MESH:D004837
80 1743-1754 Chemical denotes epinephrine MESH:D004837
81 79-84 Disease denotes death MESH:D003643
82 551-559 Disease denotes flushing MESH:D005483
83 578-583 Disease denotes edema MESH:D004487
84 595-601 Disease denotes nausea MESH:D009325
85 603-611 Disease denotes vomiting MESH:D014839
86 613-624 Disease denotes tachycardia MESH:D013610
87 626-637 Disease denotes hypotension MESH:D007022

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T13 0-274 Sentence denotes Anaphylaxis is a serious multisystem reaction with rapid onset and can lead to death by asphyxiation, cardiovascular collapse, and other complications.4 It requires prompt recognition and treatment with epinephrine to halt the rapid progression of life-threatening symptoms.
T14 275-667 Sentence denotes The cause of anaphylactic reactions is the activation of mast cells through antigen binding and cross-linking of IgE; the symptoms result from the tissue response to the release of mediators such as histamine, proteases, prostaglandins, and leukotrienes and typically include flushing, hives, laryngeal edema, wheezing, nausea, vomiting, tachycardia, hypotension, and cardiovascular collapse.
T15 668-732 Sentence denotes Patients become IgE-sensitized by previous exposure to antigens.
T16 733-932 Sentence denotes Reactions that resemble the clinical signs and symptoms of anaphylaxis, previously known as anaphylactoid reactions, are now referred to as non-IgE–mediated reactions because they do not involve IgE.
T17 933-1141 Sentence denotes They manifest the same clinical features and response to epinephrine, but they occur by direct activation of mast cells and basophils, complement activation, or other pathways and can occur on first exposure.
T18 1142-1355 Sentence denotes Tryptase is typically elevated in blood in IgE-mediated anaphylaxis and, to a lesser extent, in non–IgE-mediated mast-cell activation, a feature that identifies mast cells as the sources of inflammatory mediators.
T19 1356-1755 Sentence denotes Prick and intradermal skin testing and analysis of blood samples for serum IgE are used to identify the specific drug culprit, although the tests lack 100% negative predictive value.5 The clinical manifestations of the two U.K. cases and the one U.S. case fit the description of anaphylaxis: they occurred within minutes after the injections, symptoms were typical, and all responded to epinephrine.
T20 1756-1932 Sentence denotes The occurrence on first exposure is not typical of IgE-mediated reactions; however, preexisting sensitization to a component of the vaccine could account for this observation.4