PMC:7787218 / 17498-19977 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7787218","sourcedb":"PMC","sourceid":"7787218","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7787218","text":"Vaccine Platform Type of Vaccine and Immunogen Developer(Name of Vaccine) Dose Scheduleand Administration Phase* Excipients†\nRNA-based vaccine mRNA encoding spike protein (30 μg) BioNTech–Pfizer(BNT162b2) Two doses (day 0, day 21)\nIntramuscular Post-EUA 0.43 mg ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 0.05 mg2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide, 0.09 mg 1,2-distearoyl-sn-glycero-3-phosphocholine, and 0.2 mg cholesterol, 0.01 mg potassium chloride, 0.01 mg monobasic potassium phosphate, 0.36 mg sodium chloride, 0.07 mg dibasic sodium phosphate dihydrate, and 6 mg sucrose. The diluent (0.9% sodium chloride Injection) contributes an additional 2.16 mg sodium chloride per dose\nRNA-based vaccine mRNA encoding spike protein (100 μg) Moderna(mRNA-1273) Two doses (day 0, day 28)\nIntramuscular Post-EUA Lipids (SM-102; 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 [PEG 2000-DMG]; cholesterol; and 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]), tromethamine, tromethamine hydrochloride, acetic acid, sodium acetate, and sucrose\nAdenovirus vector (nonreplicating) ChAdOx1-Sn Cov-19\nNonreplicating chimpanzee AdV5 expressing spike protein AstraZeneca and University of Oxford(AZD1222) One (day 0) or two (day 0, day 28) doses\nIntramuscular Phase 3 10 mM histidine, 7.5% (w/v) sucrose,35 mM sodium chloride, 1 mM magnesiumchloride, 0.1% (w/v) polysorbate 80,0.1 mM edetate disodium, 0.5% (w/v)ethanol, at pH 6.6\nAdenovirus vector(nonreplicating) Ad26.COV2.S\nAdenovirus 26 vectored vaccine using AdVac and PER.C6 technology Janssen One (day 0) or two (day 0, day 56) doses\nIntramuscular Phase 3 Sodium chloride, citric acid monohydrate, polysorbate 80, 2 hydroxypropyl-B-cyclodextrin (HBCD), ethanol (absolute), sodium hydroxide\nProtein subunit Full-length recombinant SARS-CoV-2 glycoprotein nanoparticle with Matrix M adjuvant\nSpike prefusion protein Novavax Two doses (day 0, day 21)\nIntramuscular Phase 3 Matrix M1 adjuvantFull-length spike protein formulated in polysorbate 80 detergent and Matrix M1 adjuvant\nProtein subunit SARS-CoV-2 vaccine formulation with adjuvant (S-protein) (Baculovirus production)\nSpike protein Sanofi Pasteur and GSK Two doses (day 0, day 21)\nIntramuscular Phase 1–2 Sodium phosphate monobasic monohydrate, sodium phosphate dibasic, sodium chloride polysorbate 20, disodium hydrogen phosphate, potassium dihydrogen phosphate, potassium 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