PMC:7787217 / 2160-3021 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"57","span":{"begin":324,"end":327},"obj":"Gene"},{"id":"63","span":{"begin":251,"end":259},"obj":"Species"},{"id":"64","span":{"begin":413,"end":421},"obj":"Species"},{"id":"65","span":{"begin":581,"end":589},"obj":"Species"},{"id":"66","span":{"begin":275,"end":277},"obj":"Chemical"},{"id":"69","span":{"begin":31,"end":43},"obj":"Disease"},{"id":"70","span":{"begin":211,"end":234},"obj":"Disease"},{"id":"71","span":{"begin":453,"end":468},"obj":"Disease"}],"attributes":[{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Gene:925"},{"id":"A63","pred":"tao:has_database_id","subj":"63","obj":"Tax:9606"},{"id":"A64","pred":"tao:has_database_id","subj":"64","obj":"Tax:9606"},{"id":"A65","pred":"tao:has_database_id","subj":"65","obj":"Tax:9606"},{"id":"A69","pred":"tao:has_database_id","subj":"69","obj":"MESH:D007249"},{"id":"A70","pred":"tao:has_database_id","subj":"70","obj":"MESH:D001254"},{"id":"A71","pred":"tao:has_database_id","subj":"71","obj":"MESH:D057772"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"There was minimal perivascular inflammation in the specimens examined, but there was no vascular occlusion, as previously described in the Journal.1 Perivascular-activated microglia, macrophage infiltrates, and hypertrophic astrocytes were seen in 13 patients (Figure 1G and 1H, Fig. S3, and Table S4).2 There were CD3+ and CD8+ T cells in the perivascular spaces and in lumens adjacent to endothelial cells in 8 patients, which may have contributed to vascular injury (Figure 1I and 1J), as suggested in a previous report.3 Activated microglia were found adjacent to neurons in 5 patients, which is suggestive of neuronophagia in the olfactory bulb, substantia nigra, dorsal motor nucleus of the vagal nerve, and the pre-Bötzinger complex in the medulla, which is involved in the generation of spontaneous rhythmic breathing (Figure 1K through 1N and Fig. S3)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":344,"end":363},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0012520"}],"text":"There was minimal perivascular inflammation in the specimens examined, but there was no vascular occlusion, as previously described in the Journal.1 Perivascular-activated microglia, macrophage infiltrates, and hypertrophic astrocytes were seen in 13 patients (Figure 1G and 1H, Fig. S3, and Table S4).2 There were CD3+ and CD8+ T cells in the perivascular spaces and in lumens adjacent to endothelial cells in 8 patients, which may have contributed to vascular injury (Figure 1I and 1J), as suggested in a previous report.3 Activated microglia were found adjacent to neurons in 5 patients, which is suggestive of neuronophagia in the olfactory bulb, substantia nigra, dorsal motor nucleus of the vagal nerve, and the pre-Bötzinger complex in the medulla, which is involved in the generation of spontaneous rhythmic breathing (Figure 1K through 1N and Fig. S3)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T14","span":{"begin":0,"end":861},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"There was minimal perivascular inflammation in the specimens examined, but there was no vascular occlusion, as previously described in the Journal.1 Perivascular-activated microglia, macrophage infiltrates, and hypertrophic astrocytes were seen in 13 patients (Figure 1G and 1H, Fig. S3, and Table S4).2 There were CD3+ and CD8+ T cells in the perivascular spaces and in lumens adjacent to endothelial cells in 8 patients, which may have contributed to vascular injury (Figure 1I and 1J), as suggested in a previous report.3 Activated microglia were found adjacent to neurons in 5 patients, which is suggestive of neuronophagia in the olfactory bulb, substantia nigra, dorsal motor nucleus of the vagal nerve, and the pre-Bötzinger complex in the medulla, which is involved in the generation of spontaneous rhythmic breathing (Figure 1K through 1N and Fig. S3)."}