| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T9 |
0-149 |
Sentence |
denotes |
Magnetic resonance microscopy showed punctate hyperintensities in 9 patients, which represented areas of microvascular injury and fibrinogen leakage. |
| T10 |
150-292 |
Sentence |
denotes |
These features were observed on corresponding histopathological examination performed with the use of fluorescence imaging (Figure 1A and 1B). |
| T11 |
293-444 |
Sentence |
denotes |
These areas showed thinning of the basal lamina of the endothelial cells, as determined by collagen IV immunostaining in 5 patients (Fig. 1B1 and 1B2). |
| T12 |
445-663 |
Sentence |
denotes |
Punctate hypointensities on imaging in 10 patients corresponded to congested blood vessels (Figure 1C) with surrounding areas of fibrinogen leakage (Figure 1D and Fig. S1) and relatively intact vasculature (Figure 1E). |
| T13 |
664-757 |
Sentence |
denotes |
Areas of linear hypointensities were interpreted as microhemorrhages (Figure 1F and Fig. S2). |
| T14 |
758-1619 |
Sentence |
denotes |
There was minimal perivascular inflammation in the specimens examined, but there was no vascular occlusion, as previously described in the Journal.1 Perivascular-activated microglia, macrophage infiltrates, and hypertrophic astrocytes were seen in 13 patients (Figure 1G and 1H, Fig. S3, and Table S4).2 There were CD3+ and CD8+ T cells in the perivascular spaces and in lumens adjacent to endothelial cells in 8 patients, which may have contributed to vascular injury (Figure 1I and 1J), as suggested in a previous report.3 Activated microglia were found adjacent to neurons in 5 patients, which is suggestive of neuronophagia in the olfactory bulb, substantia nigra, dorsal motor nucleus of the vagal nerve, and the pre-Bötzinger complex in the medulla, which is involved in the generation of spontaneous rhythmic breathing (Figure 1K through 1N and Fig. S3). |
