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PMC:7784834 / 33891-34719 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
462 312-317 Gene denotes spike Gene:43740568
463 653-658 Gene denotes spike Gene:43740568
464 731-736 Gene denotes spike Gene:43740568
465 0-10 Species denotes SARS-CoV-2 Tax:2697049
466 279-289 Species denotes SARS-CoV-2 Tax:2697049
467 642-652 Species denotes SARS-CoV-2 Tax:2697049
468 57-65 Disease denotes COVID-19 MESH:C000657245
469 152-158 Disease denotes deaths MESH:D003643

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T236 0-182 Sentence denotes SARS-CoV-2 which causes the deadly and highly infectious COVID-19 remains an unmet medical issue that requires urgent attention, owing to the number of deaths it is causing globally.
T237 183-348 Sentence denotes We report here a computational approach for a repurposing screening program against two crucial SARS-CoV-2 drug targets viz. the spike protein and the main protease.
T238 349-510 Sentence denotes We discovered that the drug rutin, showed a high binding potency against both the drug targets and may therefore be capable of eliciting reduction in viral load.
T239 511-685 Sentence denotes The current study delineates that the highly effective repurposed drug rutin has the potential to obtain strong inhibition against SARS-CoV-2 spike protein and main protease.
T240 686-828 Sentence denotes Rutin showed high binding efficiency against spike protein and main protease having an XP Glide score of –8.367 kcal/mol and –11.553 kcal/mol.