PMC:7784830 / 12188-12744 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784830","sourcedb":"PMC","sourceid":"7784830","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784830","text":"Herpetrione (HPE) – extracted from Herpetospermum caudigerum.HPE nanoparticles were prepared using sodium dodecyl sulfate and PVP K-30 Poor water solubility and low bioavailability Hydroxypropyl methylcellulose (HPMC), microcrystalline cellulose (MCC), and l-hydroxypropyl cellulose (HPC) PEG-400 Solvent casting method (SCM) Studies established that ODFs are suitable for delivery of poorly water-soluble drugsSCM is modified to prepare drug nanosuspensionOral bioavailability of HPE nanoparticles was higher when compared HPE coarse suspension [62]","divisions":[{"label":"td","span":{"begin":0,"end":134}},{"label":"td","span":{"begin":136,"end":181}},{"label":"td","span":{"begin":183,"end":290}},{"label":"td","span":{"begin":292,"end":299}},{"label":"td","span":{"begin":301,"end":329}},{"label":"td","span":{"begin":331,"end":550}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"210","span":{"begin":141,"end":146},"obj":"Chemical"},{"id":"211","span":{"begin":397,"end":402},"obj":"Chemical"},{"id":"214","span":{"begin":286,"end":289},"obj":"Disease"}],"attributes":[{"id":"A210","pred":"tao:has_database_id","subj":"210","obj":"MESH:D014867"},{"id":"A211","pred":"tao:has_database_id","subj":"211","obj":"MESH:D014867"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"MESH:C537262"},{"subj":"210","pred":"source","obj":"LitCovid-PubTator"},{"subj":"211","pred":"source","obj":"LitCovid-PubTator"},{"subj":"214","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T105","span":{"begin":0,"end":556},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T105","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ec93b3","default":true},{"id":"LitCovid-sentences","color":"#93ceec"}]}]}}