PMC:7784830 / 10792-11979 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784830","sourcedb":"PMC","sourceid":"7784830","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784830","text":"The drugs that are being developed, mentioned in Table 1, could face many challenges when it comes to delivering to the subject. For instance, favipiravir is associated with poor water solubility and demands an injection formulation. A potential alternative to such a disadvantage of favipiravir and other similar drugs is to formulate them as ODFs. Table 2 provides a list of antiviral drugs that were successfully formulated as ODFs. It is evident from Table 2 that drugs with low solubility, bioavailability, and dose are excellent candidates for formulating as films. The most conventional method used to prepare ODFs is solvent casting method and the modern methods include printing technologies using inkjet printing, wherein antiviral drugs are printed either alone or in combination with other drugs, for instance, anticancer drugs printed alongside antiviral drugs [64,65]. In addition, antiviral ODFs can be prepared as a single layered or multi-layered dosage forms, example: entecavir [67]. Drugs could either be directly loaded onto ODFs or converted into nanoparticles before loading onto ODFs. The key ingredients include a film-forming material (polymer) and plasticizer.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"192","span":{"begin":143,"end":154},"obj":"Chemical"},{"id":"193","span":{"begin":179,"end":184},"obj":"Chemical"},{"id":"194","span":{"begin":284,"end":295},"obj":"Chemical"},{"id":"195","span":{"begin":906,"end":910},"obj":"Chemical"},{"id":"196","span":{"begin":987,"end":996},"obj":"Chemical"},{"id":"197","span":{"begin":1046,"end":1050},"obj":"Chemical"},{"id":"198","span":{"begin":1103,"end":1107},"obj":"Chemical"},{"id":"199","span":{"begin":1162,"end":1169},"obj":"Chemical"}],"attributes":[{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"MESH:C462182"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"MESH:D014867"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"MESH:C462182"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"MESH:C413685"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"MESH:D011108"},{"subj":"192","pred":"source","obj":"LitCovid-PubTator"},{"subj":"193","pred":"source","obj":"LitCovid-PubTator"},{"subj":"194","pred":"source","obj":"LitCovid-PubTator"},{"subj":"195","pred":"source","obj":"LitCovid-PubTator"},{"subj":"196","pred":"source","obj":"LitCovid-PubTator"},{"subj":"197","pred":"source","obj":"LitCovid-PubTator"},{"subj":"198","pred":"source","obj":"LitCovid-PubTator"},{"subj":"199","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T94","span":{"begin":129,"end":233},"obj":"Sentence"},{"id":"T95","span":{"begin":234,"end":349},"obj":"Sentence"},{"id":"T96","span":{"begin":350,"end":435},"obj":"Sentence"},{"id":"T97","span":{"begin":436,"end":571},"obj":"Sentence"},{"id":"T98","span":{"begin":572,"end":882},"obj":"Sentence"},{"id":"T99","span":{"begin":883,"end":1002},"obj":"Sentence"},{"id":"T100","span":{"begin":1003,"end":1108},"obj":"Sentence"},{"id":"T101","span":{"begin":1109,"end":1187},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T94","pred":"source","obj":"LitCovid-sentences"},{"subj":"T95","pred":"source","obj":"LitCovid-sentences"},{"subj":"T96","pred":"source","obj":"LitCovid-sentences"},{"subj":"T97","pred":"source","obj":"LitCovid-sentences"},{"subj":"T98","pred":"source","obj":"LitCovid-sentences"},{"subj":"T99","pred":"source","obj":"LitCovid-sentences"},{"subj":"T100","pred":"source","obj":"LitCovid-sentences"},{"subj":"T101","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#ecd493","default":true},{"id":"LitCovid-sentences","color":"#ba93ec"}]}]}}