Id |
Subject |
Object |
Predicate |
Lexical cue |
T30 |
0-126 |
Sentence |
denotes |
SARS-CoV-2 has a genome of ∼30 kilobases, which codes for multiple structural and non-structural proteins (Chan et al., 2020). |
T31 |
127-316 |
Sentence |
denotes |
The structural proteins, present on the surface of the mature virion, include the spike protein, the membrane protein, the envelope protein and the nucleocapsid protein (Chan et al., 2020). |
T32 |
317-536 |
Sentence |
denotes |
The Spike protein, of the beta coronaviruses SARS-CoV-2 and SARS-CoV, enables the attachment of the virus to the cells of the lower respiratory tract of humans to gain entry into the lung tissue (Hoffmann et al., 2020). |
T33 |
537-701 |
Sentence |
denotes |
Apart from attachment, the spike glycoprotein also appears to play a role in fusion and entry of the virus into the host (Chen et al., 2020; Hoffmann et al., 2020). |
T34 |
702-886 |
Sentence |
denotes |
The spike protein, of the novel coronavirus, utilizes the SARS-CoV receptor, ACE2 for entry (Chen et al., 2020) and is primed by the cellular protease, TMPRSS2 (Hoffmann et al., 2020). |
T35 |
887-1016 |
Sentence |
denotes |
A serine protease inhibitor, which can act on TMPRSS2, has been shown to inhibit novel coronavirus entry (Hoffmann et al., 2020). |
T36 |
1017-1230 |
Sentence |
denotes |
Therefore, the spike protein of the novel coronavirus is a good drug target and identifying small molecules that bind to S protein would inhibit viral recognition of host cells and disrupt viral-host interactions. |