PMC:7784829 / 26414-27158 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784829","sourcedb":"PMC","sourceid":"7784829","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784829","text":"The spike proteins of corona viruses are essential for entry of the virus into the target cells. The spike protein exists as a trimer on the surface of the virus with one of the monomer in up conformation and the other two in down conformation (Wrapp et al., 2020). The N-terminal region (S1) of the S protein is important for binding to the cellular receptor ACE2 (Hoffmann et al., 2020; Tai et al., 2020). The S protein undergoes priming by cellular protease, TMPRSS2 and the S2 region of the protein is responsible for fusion of viral and cellular membrane (Hoffmann et al., 2020). Therefore, identifying therapeutics for the S protein of the novel corona virus could potentially target the critical process of entry and fusion of the virus.","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T292","span":{"begin":0,"end":96},"obj":"Sentence"},{"id":"T293","span":{"begin":97,"end":265},"obj":"Sentence"},{"id":"T294","span":{"begin":266,"end":407},"obj":"Sentence"},{"id":"T295","span":{"begin":408,"end":584},"obj":"Sentence"},{"id":"T296","span":{"begin":585,"end":744},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T292","pred":"source","obj":"LitCovid-sentences"},{"subj":"T293","pred":"source","obj":"LitCovid-sentences"},{"subj":"T294","pred":"source","obj":"LitCovid-sentences"},{"subj":"T295","pred":"source","obj":"LitCovid-sentences"},{"subj":"T296","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"715","span":{"begin":101,"end":106},"obj":"Gene"},{"id":"716","span":{"begin":360,"end":364},"obj":"Gene"},{"id":"717","span":{"begin":462,"end":469},"obj":"Gene"},{"id":"718","span":{"begin":4,"end":9},"obj":"Gene"},{"id":"719","span":{"begin":646,"end":664},"obj":"Species"}],"attributes":[{"id":"A715","pred":"tao:has_database_id","subj":"715","obj":"Gene:43740568"},{"id":"A716","pred":"tao:has_database_id","subj":"716","obj":"Gene:59272"},{"id":"A717","pred":"tao:has_database_id","subj":"717","obj":"Gene:7113"},{"id":"A718","pred":"tao:has_database_id","subj":"718","obj":"Gene:43740568"},{"id":"A719","pred":"tao:has_database_id","subj":"719","obj":"Tax:2697049"},{"subj":"715","pred":"source","obj":"LitCovid-PubTator"},{"subj":"716","pred":"source","obj":"LitCovid-PubTator"},{"subj":"717","pred":"source","obj":"LitCovid-PubTator"},{"subj":"718","pred":"source","obj":"LitCovid-PubTator"},{"subj":"719","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#c693ec","default":true},{"id":"LitCovid-PubTator","color":"#93ecac"}]}]}}