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PMC:7784829 / 194-1737 JSONTXT

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LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-92 Sentence denotes COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China.
T8 93-222 Sentence denotes The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74% identity and use similar mechanisms to gain entry into the cell.
T9 223-364 Sentence denotes Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting enzyme 2 (ACE2).
T10 365-474 Sentence denotes Targeting entry of the virus has a better advantage than inhibiting the later stages of the viral life cycle.
T11 475-579 Sentence denotes The crystal structure of the SARS-CoV (6CRV: full length S protein) and SARS-CoV-2 Spike proteins (6M0J:
T12 580-668 Sentence denotes Receptor binding domain, RBD) was used to determine potential small molecule inhibitors.
T13 669-783 Sentence denotes Curcumin, a naturally occurring phytochemical in Curcuma longa, is known to have broad pharmacological properties.
T14 784-984 Sentence denotes In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry.
T15 985-1131 Sentence denotes The curcumin and its derivatives displayed binding energies, ΔG, ranging from −10.98 to −5.12 kcal/mol (6CRV) and −10.01 to −5.33 kcal/mol (6M0J).
T16 1132-1252 Sentence denotes The least binding energy was seen in bis-demethoxycurcumin with: ΔG = −10.98 kcal/mol (6CRV) and −10.01 kcal/mol (6M0J).
T17 1253-1431 Sentence denotes A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors.
T18 1432-1543 Sentence denotes However, further research is necessary to investigate the ability of these compounds as viral entry inhibitors.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
23 325-356 Gene denotes angiotensin converting enzyme 2 Gene:59272
24 358-362 Gene denotes ACE2 Gene:59272
25 945-950 Gene denotes spike Gene:43740568
26 1406-1411 Gene denotes spike Gene:43740568
27 558-563 Gene denotes Spike Gene:43740568
28 35-45 Species denotes SARS-CoV-2 Tax:2697049
29 97-115 Species denotes novel corona virus Tax:2697049
30 116-126 Species denotes SARS-CoV-2 Tax:2697049
31 140-148 Species denotes SARS-CoV Tax:694009
32 504-512 Species denotes SARS-CoV Tax:694009
33 547-557 Species denotes SARS-CoV-2 Tax:2697049
34 718-731 Species denotes Curcuma longa Tax:136217
35 1395-1405 Species denotes SARS-CoV-2 Tax:2697049
36 669-677 Chemical denotes Curcumin MESH:D003474
37 806-814 Chemical denotes curcumin MESH:D003474
38 989-997 Chemical denotes curcumin MESH:D003474
39 1169-1190 Chemical denotes bis-demethoxycurcumin MESH:C034786
40 1356-1364 Chemical denotes curcumin MESH:D003474
41 0-8 Disease denotes COVID-19 MESH:C000657245