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PMC:7784829 / 185-1772 JSONTXT

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LitCovid-sentences

Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes Abstract
T7 9-101 Sentence denotes COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China.
T8 102-231 Sentence denotes The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74% identity and use similar mechanisms to gain entry into the cell.
T9 232-373 Sentence denotes Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting enzyme 2 (ACE2).
T10 374-483 Sentence denotes Targeting entry of the virus has a better advantage than inhibiting the later stages of the viral life cycle.
T11 484-588 Sentence denotes The crystal structure of the SARS-CoV (6CRV: full length S protein) and SARS-CoV-2 Spike proteins (6M0J:
T12 589-677 Sentence denotes Receptor binding domain, RBD) was used to determine potential small molecule inhibitors.
T13 678-792 Sentence denotes Curcumin, a naturally occurring phytochemical in Curcuma longa, is known to have broad pharmacological properties.
T14 793-993 Sentence denotes In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry.
T15 994-1140 Sentence denotes The curcumin and its derivatives displayed binding energies, ΔG, ranging from −10.98 to −5.12 kcal/mol (6CRV) and −10.01 to −5.33 kcal/mol (6M0J).
T16 1141-1261 Sentence denotes The least binding energy was seen in bis-demethoxycurcumin with: ΔG = −10.98 kcal/mol (6CRV) and −10.01 kcal/mol (6M0J).
T17 1262-1440 Sentence denotes A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors.
T18 1441-1552 Sentence denotes However, further research is necessary to investigate the ability of these compounds as viral entry inhibitors.
T19 1553-1581 Sentence denotes Communicated by Ramaswamy H.
T20 1582-1587 Sentence denotes Sarma

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
23 334-365 Gene denotes angiotensin converting enzyme 2 Gene:59272
24 367-371 Gene denotes ACE2 Gene:59272
25 954-959 Gene denotes spike Gene:43740568
26 1415-1420 Gene denotes spike Gene:43740568
27 567-572 Gene denotes Spike Gene:43740568
28 44-54 Species denotes SARS-CoV-2 Tax:2697049
29 106-124 Species denotes novel corona virus Tax:2697049
30 125-135 Species denotes SARS-CoV-2 Tax:2697049
31 149-157 Species denotes SARS-CoV Tax:694009
32 513-521 Species denotes SARS-CoV Tax:694009
33 556-566 Species denotes SARS-CoV-2 Tax:2697049
34 727-740 Species denotes Curcuma longa Tax:136217
35 1404-1414 Species denotes SARS-CoV-2 Tax:2697049
36 678-686 Chemical denotes Curcumin MESH:D003474
37 815-823 Chemical denotes curcumin MESH:D003474
38 998-1006 Chemical denotes curcumin MESH:D003474
39 1178-1199 Chemical denotes bis-demethoxycurcumin MESH:C034786
40 1365-1373 Chemical denotes curcumin MESH:D003474
41 9-17 Disease denotes COVID-19 MESH:C000657245