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PMC:7784828 / 1605-3968 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1325-1331 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T2 1360-1368 Phenotype denotes dementia http://purl.obolibrary.org/obo/HP_0000726

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T22 0-2 Sentence denotes 1.
T23 4-16 Sentence denotes Introduction
T24 17-159 Sentence denotes The ongoing COVID-19 pandemic has imposed a heavy toll on human life, health care, global economy and almost every aspect of human life [1,2].
T25 160-362 Sentence denotes Yet despite its devastating effects, it has also mobilized and united many elements of the drug discovery and development process to seek therapies to address this most pressing public health emergency.
T26 363-467 Sentence denotes In a record time frame, 36 vaccines have entered in clinical trials and 89 are in preclinical phase [3].
T27 468-740 Sentence denotes While it usually takes 10–15 years to develop a vaccine, in less than a year, promising results from phase III clinical trials of the Pfizer/BioNTech vaccine were recently announced with results from trials by other pharma companies expected to follow soon (Figure 1) [4].
T28 741-750 Sentence denotes Figure 1.
T29 751-893 Sentence denotes Comparison between the traditional vaccine development timeline and the accelerated development time line in response to the COVID-19 pandemic
T30 894-1113 Sentence denotes This momentous foot is a testament to the collective human resolve and can only be achieved in the presence of a global will, collaboration, and available resources needed to tackle a global health crisis of this scale.
T31 1114-1373 Sentence denotes Yet as the world remains focused on COVID-19 pandemic, the humankind still faces several intricate diseases many of which do not obey the standard Mendelian rules of inheritance such as infectious diseases [5], cancer [6], rare diseases [7], and dementia [8].
T32 1374-1550 Sentence denotes Despite skyrocketing technological advances, the impression has gained ground that we are clueless about most of the diseases’ etiologies, progression and molecular mechanisms.
T33 1551-1702 Sentence denotes Solving unmet medical needs is still a distant dream and there is a pressing need to develop new and effective medicines for several existing diseases.
T34 1703-1825 Sentence denotes To successfully address these challenges, developing efficient strategies, novel technologies, and policies are paramount.
T35 1826-1954 Sentence denotes The mounting cost, risk, and timely process are significant obstacles that hinders the drug discovery and development processes.
T36 1955-2176 Sentence denotes As global momentum continues to materialize in an effort to address the ongoing pandemic, valuable lessons and perhaps plunders can be learned and applied to address other global health-related challenges humankind faces.
T37 2177-2363 Sentence denotes In the following sections, major perplexing challenges to the health of humankind, the hurdles facing drug discovery and development and frontiers for potential solutions, are addressed.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3 876-884 Disease denotes COVID-19 MESH:C000657245
7 75-80 Species denotes human Tax:9606
8 142-147 Species denotes human Tax:9606
9 29-37 Disease denotes COVID-19 MESH:C000657245
15 947-952 Species denotes human Tax:9606
16 1150-1158 Disease denotes COVID-19 MESH:C000657245
17 1300-1319 Disease denotes infectious diseases MESH:D003141
18 1325-1331 Disease denotes cancer MESH:D009369
19 1360-1368 Disease denotes dementia MESH:D003704