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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
158 234-242 Species denotes patients Tax:9606
159 299-307 Disease denotes COVID-19 MESH:C000657245
169 1117-1120 Gene denotes ANF Gene:4878
170 976-994 Species denotes Epstein-Barr virus Tax:10376
171 1012-1029 Species denotes Toxoplasma gondii Tax:5811
172 1145-1153 Species denotes patients Tax:9606
173 1171-1181 Species denotes SARS-CoV-2 Tax:2697049
174 1190-1203 Species denotes coronaviruses Tax:11118
175 996-999 Species denotes EBV Tax:10376
176 1031-1035 Species denotes Toxo Tax:5811
177 782-790 Disease denotes COVID-19 MESH:C000657245
224 1348-1356 Species denotes patients Tax:9606
225 1330-1338 Disease denotes COVID-19 MESH:C000657245
238 4197-4202 Gene denotes Prima Gene:145270
239 3383-3391 Species denotes patients Tax:9606
240 3689-3697 Species denotes patients Tax:9606
241 3972-3980 Species denotes Patients Tax:9606
242 4028-4038 Species denotes SARS-CoV-2 Tax:2697049
243 4267-4275 Species denotes patients Tax:9606
244 4345-4353 Species denotes patients Tax:9606
245 4460-4470 Species denotes SARS-CoV-2 Tax:2697049
246 3519-3527 Disease denotes COVID-19 MESH:C000657245
247 4107-4115 Disease denotes COVID-19 MESH:C000657245
248 4168-4176 Disease denotes COVID-19 MESH:C000657245
249 4299-4307 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T83 0-12 Sentence denotes Study design
T84 13-166 Sentence denotes The study was approved by the local ethics committee (BC-07829) of the Ghent University Hospital, a 1062-beds tertiary care teaching hospital in Belgium.
T85 167-388 Sentence denotes From March 12th to 31st 2020, 23 consecutive sera from 7 different patients, admitted to the hospital with a confirmed diagnosis of COVID-19 based on positive RT-PCR [6], were collected on day 2 to 18 after symptom onset.
T86 389-440 Sentence denotes The study group consisted of 2 females and 5 males.
T87 441-489 Sentence denotes The median age was 58 years (range 39–81 years).
T88 490-665 Sentence denotes The collected sera were divided into 2 groups: day 2–7 after symptom onset (7 samples) and day 8–18 after symptom onset (16 samples) in order to evaluate clinical sensitivity.
T89 666-856 Sentence denotes Specificity was evaluated using 10 pre-pandemic sera, i.e. clinical samples sent to the hospital laboratory for non-COVID-19-related serological investigations from August to September 2019.
T90 857-1228 Sentence denotes Furthermore, 9 potential cross-reactive sera were included, i.e. IgM positivity against Cytomegalovirus (CMV) (n = 2), Epstein-Barr virus (EBV) (n = 2) or Toxoplasma gondii (Toxo) (n = 1); samples positive for rheumafactor (RF) (n = 1) or anti-nuclear factor (ANF) (n = 1)) and sera from patients positive for non-SARS-CoV-2 endemic coronaviruses (OC43 and NL63) (n = 2).
T91 1229-1447 Sentence denotes The 14 serological assays listed in Table 1 were performed on each of the 23 sera from PCR confirmed COVID-19 positive patients and the 19 pre-pandemic/cross-reactive sera, according to the manufacturer’s instructions.
T92 1448-1506 Sentence denotes Sensitivity and specificity were calculated for each test.
T93 1507-1724 Sentence denotes We calculated both the overall sensitivity (day 2–18 after symptom onset) and the sensitivity of the two subgroups (day 2–7 and day 8–18), each time for IgM/A and IgG separately and for combined IgM/A and IgG testing.
T94 1725-1733 Sentence denotes Table 1.
T95 1734-1765 Sentence denotes Overview of the included assays
T96 1766-1823 Sentence denotes Test Assay Company Antibody detection Recombinant antigen
T97 1824-1842 Sentence denotes Point-of-care test
T98 1843-1932 Sentence denotes Corona Virus (COVID-19) Combined IgM/IgG Rapid Test Sol Scientifics IgM+IgG Not specified
T99 1933-2035 Sentence denotes COVID-19 IgG/igM Rapid Test Cassette Zhejiang ORIENT GENE Biotech IgM+IgG Spike + nucleocapsid protein
T100 2036-2146 Sentence denotes Wantai SARS-COV-2 Ab Rapid Test Beijing Wantai Biological Pharmacy Enterprise IgM+IgG (combined) Not specified
T101 2147-2215 Sentence denotes COVID-19 IgG/IgM RAPID TEST PRIMA PROFESSIONAL IgM+IgG Not specified
T102 2216-2299 Sentence denotes Diagnostic Kit for IgG/IgM Antibody to SARS-CoV-2 WIZ BIOTECH IgM+IgG Not specified
T103 2300-2341 Sentence denotes Enzyme-Linked Immunosorbent Assay (ELISA)
T104 2342-2412 Sentence denotes Anti-SARS-CoV-2 ELISA (IgA) EUROIMMUN S1 Spike glycoprotein (S1domain)
T105 2413-2484 Sentence denotes Anti-SARS-CoV-2 ELISA (IgG) EUROIMMUN IgG Spike glycoprotein (S1domain)
T106 2485-2569 Sentence denotes Novel Coronavirus COVID-19 IgM ELISA Kit Epitope Diagnostics (EDI) IgM Not specified
T107 2570-2661 Sentence denotes Novel Coronavirus COVID-19 IgG ELISA Kit Epitope Diagnostics (EDI) IgG Nucleocapsid protein
T108 2662-2725 Sentence denotes SARS-CoV-2 IgM ELISA Kit Creative Diagnostics IgM Not specified
T109 2726-2789 Sentence denotes SARS-CoV-2 IgG ELISA kit Creative Diagnostics IgG Not specified
T110 2790-2866 Sentence denotes Human Anti-2019 nCoV(N) IgG ELISA kit Finetest, Wuhan Fine Biotech Co., Ltd.
T111 2867-2900 Sentence denotes IgG Spike glycoprotein (S1domain)
T112 2901-2950 Sentence denotes Chemiluminescent microparticle immunoassay (CMIA)
T113 2951-2997 Sentence denotes SARS-CoV-2 IgG Abbott IgG Nucleocapsid protein
T114 2998-3034 Sentence denotes Chemiluminescence immunoassay (CLIA)
T115 3035-3094 Sentence denotes Liaison SARS-CoV-2 S1/S2 IgG DiaSorin IgG S1 and S2 protein
T116 3095-3241 Sentence denotes Sensitivity and specificity were calculated by means of Excel (version 16.0, Microsoft, Washington, USA) using the following definitions in Excel:
T117 3242-3310 Sentence denotes Sensitivity = 100 x [True Positive/(True Positive + False Negative)]
T118 3311-3378 Sentence denotes Specificity = 100 x [True Negative/(True Negative +False Positive)]
T119 3379-3681 Sentence denotes All patients consulting at the emergency department of our hospital from the 1st of March till the 14th of May, with symptoms suggestive of COVID-19 disease that required hospital admission and for which laboratory diagnosis was performed in our institution were retrospectively included in a database.
T120 3682-3781 Sentence denotes In all patients a RT-PCR test on nasopharyngeal/throat swab was performed at the time of admission.
T121 3782-3906 Sentence denotes If the initial nasopharyngeal swab was found to be negative, a second nasopharyngeal and additional anal swab were analyzed.
T122 3907-3971 Sentence denotes If still negative, a bronchoalveolar lavage (BAL) was performed.
T123 3972-4218 Sentence denotes Patients with repetitive negative molecular testing for SARS-CoV-2 but high clinical, epidemiological and/or radiological suspicion of COVID-19 disease were subjected to serological testing using COVID-19 IgG/IgM rapid test (Prima Professional®).
T124 4219-4403 Sentence denotes Among this retrospective cohort of hospitalized patients clinically treated for COVID-19 disease, we calculated the number of patients that ultimately had a RT-PCR confirmed diagnosis.
T125 4404-4515 Sentence denotes As such, an estimation of the added diagnostic value of SARS-CoV-2 serology in this cohort could be calculated.