> top > docs > PMC:7784786 > spans > 4307-11788 > annotations

PMC:7784786 / 4307-11788 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
192 728-736 Gene denotes IFN α-2b Gene:3440
193 1036-1039 Gene denotes ALP Gene:470
194 1573-1577 Gene denotes IL-6 Gene:3569
195 1685-1689 Gene denotes IL-6 Gene:3569
196 1775-1779 Gene denotes IL-1 Gene:3553
197 1860-1887 Gene denotes aspartate amino transferase Gene:26503
198 1889-1892 Gene denotes AST Gene:26503
199 43-48 Species denotes woman Tax:9606
200 426-436 Species denotes SARS-CoV-2 Tax:2697049
201 1275-1282 Species denotes Patient Tax:9606
202 1505-1512 Species denotes patient Tax:9606
203 535-541 Chemical denotes oxygen MESH:D010100
204 563-569 Chemical denotes oxygen MESH:D010100
205 571-574 Chemical denotes PO2 MESH:C093415
206 575-579 Chemical denotes FiO2
207 682-701 Chemical denotes lopinavir/ritonavir MESH:C558899
208 703-714 Chemical denotes chloroquine MESH:D002738
209 741-749 Chemical denotes rocephin MESH:D002443
210 1114-1124 Chemical denotes itolizumab MESH:C000597346
211 1170-1180 Chemical denotes itolizumab MESH:C000597346
212 1187-1190 Chemical denotes PO2 MESH:C093415
213 1191-1195 Chemical denotes FiO2
214 1607-1617 Chemical denotes itolizumab MESH:C000597346
215 2048-2058 Chemical denotes itolizumab MESH:C000597346
216 86-98 Disease denotes hypertension MESH:D006973
217 103-127 Disease denotes Type 2 diabetes mellitus MESH:D003924
218 155-163 Disease denotes polypnea
219 230-239 Disease denotes dry cough MESH:D003371
220 282-290 Disease denotes COVID-19 MESH:C000657245
221 339-347 Disease denotes COVID-19 MESH:C000657245
222 472-481 Disease denotes hypoxemia MESH:D000860
223 486-507 Disease denotes respiratory alkalosis MESH:D000472
224 823-842 Disease denotes respiratory failure MESH:D012131
225 983-1016 Disease denotes interstitial multifocal pneumonia
227 2134-2144 Chemical denotes itolizumab MESH:C000597346
234 2167-2177 Chemical denotes itolizumab MESH:C000597346
235 2313-2323 Chemical denotes itolizumab MESH:C000597346
236 2536-2546 Chemical denotes itolizumab MESH:C000597346
237 2663-2673 Chemical denotes itolizumab MESH:C000597346
238 2285-2301 Disease denotes pleural effusion MESH:D010996
239 2488-2504 Disease denotes pleural effusion MESH:D010996
241 2825-2832 Species denotes patient Tax:9606
246 2841-2845 Gene denotes IL-6 Gene:3569
247 2850-2853 Gene denotes AST Gene:26503
248 2912-2920 Species denotes patients Tax:9606
249 2928-2938 Chemical denotes itolizumab MESH:C000597346
303 4016-4019 Gene denotes AST Gene:26503
304 4047-4065 Gene denotes C-reactive protein Gene:1401
305 4188-4196 Gene denotes IFN α-2b Gene:3440
306 5152-5156 Gene denotes IL-6 Gene:3569
307 5267-5271 Gene denotes IL-6 Gene:3569
308 5424-5428 Gene denotes IL-6 Gene:3569
309 5472-5476 Gene denotes IL-6 Gene:3569
310 5478-5482 Gene denotes IL-1 Gene:3553
311 5563-5566 Gene denotes AST Gene:26503
312 3919-3926 Species denotes Patient Tax:9606
313 4590-4597 Species denotes patient Tax:9606
314 4864-4871 Species denotes patient Tax:9606
315 5065-5072 Species denotes patient Tax:9606
316 5718-5725 Species denotes patient Tax:9606
317 3611-3617 Chemical denotes oxygen MESH:D010100
318 4154-4173 Chemical denotes lopinavir–ritonavir MESH:C558899
319 4175-4186 Chemical denotes chloroquine MESH:D002738
320 4198-4207 Chemical denotes meropenem MESH:D000077731
321 4212-4221 Chemical denotes linezolid MESH:D000069349
322 4278-4288 Chemical denotes itolizumab MESH:C000597346
323 4420-4423 Chemical denotes PO2 MESH:C093415
324 4424-4428 Chemical denotes FiO2
325 4472-4475 Chemical denotes PO2 MESH:C093415
326 4476-4480 Chemical denotes FiO2
327 4506-4509 Chemical denotes PO2 MESH:C093415
328 5097-5107 Chemical denotes itolizumab MESH:C000597346
329 5186-5196 Chemical denotes itolizumab MESH:C000597346
330 5809-5823 Chemical denotes norepinephrine MESH:D009638
331 3015-3035 Disease denotes ischemic cardiopathy MESH:C536187
332 3047-3066 Disease denotes atrial fibrillation MESH:D001281
333 3068-3080 Disease denotes hypertension MESH:D006973
334 3085-3099 Disease denotes hypothyroidism MESH:D007037
335 3130-3140 Disease denotes alcoholism MESH:D000437
336 3219-3239 Disease denotes respiratory diseases MESH:D012140
337 3292-3311 Disease denotes shortness of breath MESH:D004417
338 3313-3318 Disease denotes fever MESH:D005334
339 3320-3328 Disease denotes asthenia MESH:D001247
340 3333-3342 Disease denotes dry cough MESH:D003371
341 3419-3427 Disease denotes COVID-19 MESH:C000657245
342 3479-3498 Disease denotes respiratory failure MESH:D012131
343 3516-3527 Disease denotes tachycardia MESH:D013610
344 3529-3537 Disease denotes polypnea
345 3790-3809 Disease denotes atrial fibrillation MESH:D001281
346 3882-3891 Disease denotes hypoxemia MESH:D000860
347 3896-3917 Disease denotes respiratory alkalosis MESH:D000472
348 3936-3948 Disease denotes leukocytosis MESH:D007964
349 4663-4687 Disease denotes alveolar hypoventilation MESH:C536281
350 4717-4729 Disease denotes pneumothorax MESH:D011030
351 4764-4776 Disease denotes pneumothorax MESH:D011030
352 5738-5760 Disease denotes myocardial dysfunction MESH:D009202
353 5765-5770 Disease denotes shock MESH:D012769
354 5847-5851 Disease denotes died MESH:D003643
355 5875-5913 Disease denotes cardiovascular and respiratory failure MESH:D012131
381 6431-6439 Gene denotes IFN α-2b Gene:3440
382 7037-7041 Gene denotes IL-6 Gene:3569
383 7114-7118 Gene denotes IL-6 Gene:3569
384 7290-7294 Gene denotes IL-1 Gene:3553
385 7299-7304 Gene denotes TNF-α Gene:7124
386 7386-7389 Gene denotes AST Gene:26503
387 6099-6106 Species denotes Patient Tax:9606
388 6526-6533 Species denotes Patient Tax:9606
389 6961-6968 Species denotes Patient Tax:9606
390 7260-7267 Species denotes patient Tax:9606
391 6336-6342 Chemical denotes Oxygen MESH:D010100
392 6381-6392 Chemical denotes ceftriaxone MESH:D002443
393 6394-6413 Chemical denotes lopinavir–ritonavir MESH:C558899
394 6415-6426 Chemical denotes chloroquine MESH:D002738
395 6642-6652 Chemical denotes itolizumab MESH:C000597346
396 7222-7232 Chemical denotes itolizumab MESH:C000597346
397 5956-5964 Disease denotes COVID-19 MESH:C000657245
398 6133-6145 Disease denotes hypertension MESH:D006973
399 6147-6164 Disease denotes diabetes mellitus MESH:D003920
400 6166-6174 Disease denotes glaucoma MESH:D005901
401 6225-6230 Disease denotes cough MESH:D003371
402 6245-6253 Disease denotes diarrhea MESH:D003967
403 6272-6287 Disease denotes viral pneumonia
404 6291-6299 Disease denotes COVID-19 MESH:C000657245
405 6829-6849 Disease denotes respiratory distress MESH:D012128

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 86-98 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T10 103-118 Phenotype denotes Type 2 diabetes http://purl.obolibrary.org/obo/HP_0005978
T11 155-163 Phenotype denotes polypnea http://purl.obolibrary.org/obo/HP_0002789
T12 230-239 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T13 472-481 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T14 486-507 Phenotype denotes respiratory alkalosis http://purl.obolibrary.org/obo/HP_0001950
T15 823-842 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T16 1007-1016 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T17 2285-2301 Phenotype denotes pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T18 2488-2504 Phenotype denotes pleural effusion http://purl.obolibrary.org/obo/HP_0002202
T19 3037-3066 Phenotype denotes permanent atrial fibrillation http://purl.obolibrary.org/obo/HP_0004754
T20 3068-3080 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T21 3085-3099 Phenotype denotes hypothyroidism http://purl.obolibrary.org/obo/HP_0000821
T22 3130-3140 Phenotype denotes alcoholism http://purl.obolibrary.org/obo/HP_0030955
T23 3292-3311 Phenotype denotes shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T24 3313-3318 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T25 3320-3328 Phenotype denotes asthenia http://purl.obolibrary.org/obo/HP_0025406
T26 3333-3342 Phenotype denotes dry cough http://purl.obolibrary.org/obo/HP_0031246
T27 3479-3498 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T28 3516-3527 Phenotype denotes tachycardia http://purl.obolibrary.org/obo/HP_0001649
T29 3529-3537 Phenotype denotes polypnea http://purl.obolibrary.org/obo/HP_0002789
T30 3590-3609 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T31 3655-3665 Phenotype denotes drowsiness http://purl.obolibrary.org/obo/HP_0002329
T32 3790-3809 Phenotype denotes atrial fibrillation http://purl.obolibrary.org/obo/HP_0005110
T33 3882-3891 Phenotype denotes hypoxemia http://purl.obolibrary.org/obo/HP_0012418
T34 3896-3917 Phenotype denotes respiratory alkalosis http://purl.obolibrary.org/obo/HP_0001950
T35 3936-3948 Phenotype denotes leukocytosis http://purl.obolibrary.org/obo/HP_0001974
T36 4339-4360 Phenotype denotes pulmonary infiltrates http://purl.obolibrary.org/obo/HP_0002113
T37 4663-4687 Phenotype denotes alveolar hypoventilation http://purl.obolibrary.org/obo/HP_0002791
T38 4692-4703 Phenotype denotes atelectasis http://purl.obolibrary.org/obo/HP_0100750
T39 4717-4729 Phenotype denotes pneumothorax http://purl.obolibrary.org/obo/HP_0002107
T40 4764-4776 Phenotype denotes pneumothorax http://purl.obolibrary.org/obo/HP_0002107
T41 5765-5770 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T42 5894-5913 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878
T43 6133-6145 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T44 6147-6164 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T45 6166-6174 Phenotype denotes glaucoma http://purl.obolibrary.org/obo/HP_0000501
T46 6225-6230 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T47 6232-6240 Phenotype denotes wheezing http://purl.obolibrary.org/obo/HP_0030828
T48 6245-6253 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T49 6278-6287 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T50 6829-6849 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T37 0-17 Sentence denotes Cases description
T38 18-28 Sentence denotes Patient 1:
T39 29-240 Sentence denotes A 53-year old woman with a personal history of essential hypertension and Type 2 diabetes mellitus presented with symptoms of polypnea of more than 40 rpm, use of respiratory ancillary musculature and dry cough.
T40 241-305 Sentence denotes She arrived from a foreign country where COVID-19 was spreading.
T41 306-437 Sentence denotes Symptoms started on 23 March and COVID-19 was diagnosed on 26 March on the basis of positive real time PCR (RT-PCR) for SARS-CoV-2.
T42 438-594 Sentence denotes Initial gasometry showed moderate hypoxemia and respiratory alkalosis with a partial pressure of oxygen/fraction of inspired oxygen (PO2/FiO2) ratio of 191.
T43 595-656 Sentence denotes Chest x-rays showed interstitial lesions in both lung fields.
T44 657-750 Sentence denotes She started therapy with lopinavir/ritonavir, chloroquine, recombinant IFN α-2b and rocephin.
T45 751-904 Sentence denotes In spite of treatment, the illness subsequently progressed to hypoxemic respiratory failure warranting the initiation of invasive mechanical ventilation.
T46 905-1089 Sentence denotes At day 13 of her admission in the ICU, she showed radiologic worsening of the interstitial multifocal pneumonia, with elevation of ALP, LDH, erythrocyte sedimentation rate and D-dimer.
T47 1090-1145 Sentence denotes Physicians administered itolizumab at a dose of 200 mg.
T48 1146-1274 Sentence denotes After 48 h of the first itolizumab dose, PO2/FiO2 improved and there were evidences of radiological improvement (Figure 1A & B).
T49 1275-1381 Sentence denotes Patient was extubated after the first dose of the antibody and her status changed from critical to severe.
T50 1382-1465 Sentence denotes She received a second dose of the antibody (200 mg), 48 h after the first infusion.
T51 1466-1572 Sentence denotes 3 days after the first administration, patient was hemodynamically stable and has spontaneous ventilation.
T52 1573-1684 Sentence denotes IL-6 levels were evaluated before itolizumab administration and after 2 and 7 days of the first administration.
T53 1685-1774 Sentence denotes IL-6 levels reduced overtime from 172 pg/ml to 60 pg/ml (day 7) as depicted in Figure 2A.
T54 1775-1846 Sentence denotes IL-1 was evaluated at the same time intervals, but it was undetectable.
T55 1847-2016 Sentence denotes In addition, aspartate amino transferase (AST) concentrations were evaluated at different time points showing a reduction from 43 U/l to 24 U/l after 7 days (Figure 2B).
T56 2017-2073 Sentence denotes No adverse events related with itolizumab were reported.
T57 2074-2083 Sentence denotes Figure 1.
T58 2085-2145 Sentence denotes Radiological images before and after one dose of itolizumab.
T59 2146-2273 Sentence denotes Patient 1 (A) Before itolizumab (D0): diffuse Interstitial-alveolar infiltrate in both lung fields, predominantly in the bases.
T60 2274-2477 Sentence denotes Minor left pleural effusion. (B) After itolizumab (48 h): radiological improvement with decreased diffuse infiltrate and radio-opacity at the top of both lungs and in both lung bases, in less proportion.
T61 2478-2514 Sentence denotes The minor pleural effusion persists.
T62 2515-2787 Sentence denotes Patient 3 (C) Before itolizumab (D0): alveolar interstitial inflammatory infiltrate in both lung fields, predominantly on the right side. (D) After itolizumab (48 h): radiological improvement with significant decrease of the alveolar interstitial infiltrate of both lungs.
T63 2788-2797 Sentence denotes Figure 2.
T64 2799-2840 Sentence denotes Circulating biomarkers in patient's sera.
T65 2841-2949 Sentence denotes IL-6 and AST concentrations kinetics (A & B, respectively) measured in patients during itolizumab treatment.
T66 2950-2960 Sentence denotes Patient 2:
T67 2961-3100 Sentence denotes An 89-year old man with a personal history of chronic ischemic cardiopathy, permanent atrial fibrillation, hypertension and hypothyroidism.
T68 3101-3240 Sentence denotes He has a previous history of alcoholism and several hospital admissions in the last 3 months on account of infectious respiratory diseases.
T69 3241-3343 Sentence denotes He came to the hospital on 2 April after 7 days of shortness of breath, fever, asthenia and dry cough.
T70 3344-3442 Sentence denotes He was in contact with a person who returned from a foreign country, where COVID-19 was extending.
T71 3443-3666 Sentence denotes Physical examination shows signs of respiratory failure characterized by tachycardia, polypnea, intercostal and supraclavicular muscle retraction, high blood pressure, oxygen saturation of 82%, poor diuresis and drowsiness.
T72 3667-3765 Sentence denotes Chest x-rays showed bilateral pulmonary inflammatory infiltrates, predominantly in the right lung.
T73 3766-3918 Sentence denotes Admission ECG showed an atrial fibrillation with rapid ventricular response and the initial gasometry showed severe hypoxemia and respiratory alkalosis.
T74 3919-4066 Sentence denotes Patient also had leukocytosis, altered globular sedimentation rate as well as elevated values of AST, LDH, D-dimer and positive C-reactive protein.
T75 4067-4138 Sentence denotes He was admitted into the ICU requiring invasive mechanical ventilation.
T76 4139-4236 Sentence denotes Treatment with lopinavir–ritonavir, chloroquine, IFN α-2b, meropenem and linezolid was initiated.
T77 4237-4436 Sentence denotes 3 days after his admission into the ICU, itolizumab was prescribed, due to worsening of the bilateral pulmonary infiltrates together with a deterioration of the ventilatory function (PO2/FiO2 = 173).
T78 4437-4575 Sentence denotes After the first antibody infusion, PO2/FiO2 significantly increased (PO2/FiO2 = 320) and there were evidences of radiological improvement.
T79 4576-4746 Sentence denotes 3 days after, patient showed radiological worsening of the left lung, characterized by alveolar hypoventilation and atelectasis; then, a 70% pneumothorax was established.
T80 4747-4859 Sentence denotes Treatment of the pneumothorax with minimal pleurotomy was very demanding and required 3 days for the resolution.
T81 4860-5054 Sentence denotes The patient received a second infusion of the monoclonal antibody 72 h after the first, while a third dose was administered at the discretion of the treating physicians, 2 days after the second.
T82 5055-5151 Sentence denotes In total, patient received three doses of itolizumab (200 mg) without any related adverse event.
T83 5152-5266 Sentence denotes IL-6 levels were evaluated before itolizumab administration and after 2, 4 and 7 days of the first administration.
T84 5267-5423 Sentence denotes IL-6 was extremely high at baseline (623 pg/ml) and even though cytokine levels reduced roughly 50%, the lowest value remained above 300 pg/ml after 7 days.
T85 5424-5460 Sentence denotes IL-6 kinetics is shown in Figure 2A.
T86 5461-5534 Sentence denotes Apart from IL-6, IL-1 was undetectable at this time point of the disease.
T87 5535-5628 Sentence denotes Interesting, in the case of AST, a significant reduction is detecting at day 7 (pretreatment:
T88 5629-5641 Sentence denotes 156 U/l, D7:
T89 5642-5676 Sentence denotes 40 U/l) as is showed in Figure 2B.
T90 5677-5824 Sentence denotes After 10 days of admission into the ICU, patient presented a myocardial dysfunction and shock that required vasoactive support with norepinephrine.
T91 5825-5914 Sentence denotes On day 13, he finally died, on account of a mixed cardiovascular and respiratory failure.
T92 5915-5925 Sentence denotes Patient 3:
T93 5926-6034 Sentence denotes An 81-year old female, who is COVID-19 positive contact was not identified at the moment of hospitalization.
T94 6035-6193 Sentence denotes She started symptoms on 2 April and entered the ICU on 5 April. Patient has a previous history of hypertension, diabetes mellitus, glaucoma and smoking habit.
T95 6194-6254 Sentence denotes She was admitted with frequent cough, wheezing and diarrhea.
T96 6255-6335 Sentence denotes The diagnosis of viral pneumonia by COVID-19 was confirmed by RT-PCR on 7 April.
T97 6336-6454 Sentence denotes Oxygen support at 5 l/min and treatment with ceftriaxone, lopinavir–ritonavir, chloroquine and IFN α-2b was indicated.
T98 6455-6525 Sentence denotes Chest images showed bilateral interstitial infiltration in both lungs.
T99 6526-6631 Sentence denotes Patient condition was classified as severe, although she did not require invasive mechanical ventilation.
T100 6632-6713 Sentence denotes A dose of itolizumab (200 mg) was given the day after her admission into the ICU.
T101 6714-6960 Sentence denotes Two days after the antibody administration, together with the rest of the therapy, there was an improvement of the respiratory distress while the chest image showed a decrease of the alveolar interstitial infiltrate of both lungs (Figure 1C & D).
T102 6961-7036 Sentence denotes Patient left the ICU after a favorable clinical and radiological evolution.
T103 7037-7113 Sentence denotes IL-6 concentration was measured prior and after the antibody administration.
T104 7114-7289 Sentence denotes IL-6 level at baseline was lower than in previous cases (30 pg/ml), but also decreased 48 h and 168 h after itolizumab infusion, in parallel with patient recovery (Figure 2A).
T105 7290-7372 Sentence denotes IL-1 and TNF-α were untraceable before and 48 h after the antibody administration.
T106 7373-7481 Sentence denotes Regarding to AST concentration, the values were in the normal range during the treatment period (Figure 2B).