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PMC:7784786 / 3027-4305 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
138 163-166 Gene denotes CD6 Gene:923
139 336-341 Gene denotes ALCAM Gene:214
140 346-350 Gene denotes IL-2 Gene:3558
141 461-466 Gene denotes IFN-γ Gene:3458
142 468-472 Gene denotes IL-6 Gene:3569
143 477-482 Gene denotes TNF-α Gene:7124
144 765-769 Gene denotes IL-6 Gene:3569
145 771-776 Gene denotes TNF-α Gene:7124
146 781-786 Gene denotes IFN-γ Gene:3458
147 157-162 Species denotes human Tax:9606
148 552-560 Species denotes patients Tax:9606
149 647-655 Species denotes patients Tax:9606
150 1091-1099 Species denotes patients Tax:9606
151 1246-1254 Species denotes patients Tax:9606
152 0-10 Chemical denotes Itolizumab MESH:C000597346
153 690-700 Chemical denotes itolizumab MESH:C000597346
154 981-991 Chemical denotes itolizumab MESH:C000597346
155 585-594 Disease denotes psoriasis MESH:D011565
156 668-677 Disease denotes psoriasis MESH:D011565
157 1082-1090 Disease denotes COVID-19 MESH:C000657245

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T7 585-594 Phenotype denotes psoriasis http://purl.obolibrary.org/obo/HP_0003765
T8 668-677 Phenotype denotes psoriasis http://purl.obolibrary.org/obo/HP_0003765

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T29 0-175 Sentence denotes Itolizumab is a humanized monoclonal antibody developed at the Center of Molecular Immunology, in Cuba, that recognizes a region in the distal domain of the human CD6 [10,11].
T30 176-359 Sentence denotes The antibody reduces the expression of the intracellular proteins involved in activation and inhibits the proliferation of T cells, even in the presence of the ALCAM and IL-2 [10–12].
T31 360-491 Sentence denotes The effect is associated with the reduction of the secretion of pro-inflammatory cytokines including IFN-γ, IL-6 and TNF-α [13,14].
T32 492-603 Sentence denotes The antibody has demonstrated to be safe and efficacious in patients with moderate to severe psoriasis [15,16].
T33 604-795 Sentence denotes Studies from blood and tissue samples from patients with severe psoriasis showed that itolizumab reduces the proliferation of T cells and serum concentration of IL-6, TNF-α and IFN-γ [13–16].
T34 796-880 Sentence denotes A significant reduction of the inflammatory pattern was also observed in the tissue.
T35 881-1130 Sentence denotes On account of its well proven effect on T-cell activation and proinflammatory cytokines production, itolizumab was included as part of a Cuban expanded access protocol in critical, severe and moderate COVID-19 patients with high risk of aggravation.
T36 1131-1278 Sentence denotes The study will be published soon (manuscript accepted) and here we describe in detail the outcome of three initial patients receiving the antibody.