PMC:7784786 / 16529-18065
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7784786","sourcedb":"PMC","sourceid":"7784786","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7784786","text":"Conclusion\nIn summary, in these severe and critically ill patients, itolizumab was able to reduce IL-6 concentrations. Notably, itolizumab-related adverse events were not reported. Patients with baseline IL-6 levels below 200 pg/ml, showed prompt clinical and radiological recovery. We anticipate that the timely use of this anti-inflammatory antibody in combination with the appropriate antiviral and anticoagulant therapy could reduce the mortality associated with COVID-19. The analysis of the complete-series will be published shortly.\nSummary points\nInflammatory cytokine-release syndrome is associated with the progression of the coronavirus disease (COVID-19).\nNo current therapy has proven effective for the management of this syndrome so far.\nItolizumab is a humanized monoclonal antibody that recognizes human CD6 and its effect is associated with the reduction of pro-inflammatory cytokines release.\nWe present three COVID-19 cases who developed severe respiratory distress together with multifocal interstitial pneumonia.\nThe patients were treated with itolizumab combined with antiviral therapies.\nItolizumab reduced circulating IL-6 concentrations in the three COVID-19 patients.\nTwo patients showed rapid ventilatory and radiological improvement and were fully recovered.\nItolizumab-related adverse events were not reported.\nThese cases show that the timely use of this anti-inflammatory antibody in combination with the appropriate antiviral and anticoagulant therapy could reduce the mortality associated with 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