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PMC:7784786 / 15748-16527 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
562 38-42 Gene denotes IL-6 Gene:3569
563 140-144 Gene denotes IL-6 Gene:3569
564 287-291 Gene denotes IL-6 Gene:3569
565 391-395 Gene denotes IL-6 Gene:3569
566 186-193 Species denotes patient Tax:9606
567 734-741 Species denotes patient Tax:9606
568 346-356 Chemical denotes itolizumab MESH:C000597346
569 194-198 Disease denotes died MESH:D003643
570 232-260 Disease denotes cardiovascular complications MESH:D002318
571 602-628 Disease denotes hyperinflammatory syndrome MESH:D061325
572 630-640 Disease denotes thrombosis MESH:D013927
573 642-657 Disease denotes alveolar damage MESH:D055370
574 676-683 Disease denotes hypoxia MESH:D000860
575 742-746 Disease denotes died MESH:D003643

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T54 676-683 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T139 0-181 Sentence denotes Our preliminary findings support that IL-6 levels correlated with the severity of the disease and that the antibody was capable of reducing IL-6 concentration in all three subjects.
T140 182-261 Sentence denotes One patient died after subsequent respiratory and cardiovascular complications.
T141 262-366 Sentence denotes In this particular case, IL-6 concentration was extremely elevated at the moment of itolizumab infusion.
T142 367-484 Sentence denotes Although, the levels of IL-6 decreased during treatment, the values at 7 days kept still very high (above 300 pg/ml).
T143 485-565 Sentence denotes There was a transient improvement of respiratory function but it was not enough.
T144 566-779 Sentence denotes Presumably, the consequences of the hyperinflammatory syndrome (thrombosis, alveolar damage and severe tissue hypoxia) were irreversible at the moment of treatment and patient died as consequence of these factors.