PMC:7784786 / 15748-16527 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
562	38-42	Gene	denotes	IL-6	Gene:3569
563	140-144	Gene	denotes	IL-6	Gene:3569
564	287-291	Gene	denotes	IL-6	Gene:3569
565	391-395	Gene	denotes	IL-6	Gene:3569
566	186-193	Species	denotes	patient	Tax:9606
567	734-741	Species	denotes	patient	Tax:9606
568	346-356	Chemical	denotes	itolizumab	MESH:C000597346
569	194-198	Disease	denotes	died	MESH:D003643
570	232-260	Disease	denotes	cardiovascular complications	MESH:D002318
571	602-628	Disease	denotes	hyperinflammatory syndrome	MESH:D061325
572	630-640	Disease	denotes	thrombosis	MESH:D013927
573	642-657	Disease	denotes	alveolar damage	MESH:D055370
574	676-683	Disease	denotes	hypoxia	MESH:D000860
575	742-746	Disease	denotes	died	MESH:D003643

Id	Subject	Object	Predicate	Lexical cue	hp_id
T54	676-683	Phenotype	denotes	hypoxia	http://purl.obolibrary.org/obo/HP_0012418

Id	Subject	Object	Predicate	Lexical cue
T139	0-181	Sentence	denotes	Our preliminary findings support that IL-6 levels correlated with the severity of the disease and that the antibody was capable of reducing IL-6 concentration in all three subjects.
T140	182-261	Sentence	denotes	One patient died after subsequent respiratory and cardiovascular complications.
T141	262-366	Sentence	denotes	In this particular case, IL-6 concentration was extremely elevated at the moment of itolizumab infusion.
T142	367-484	Sentence	denotes	Although, the levels of IL-6 decreased during treatment, the values at 7 days kept still very high (above 300 pg/ml).
T143	485-565	Sentence	denotes	There was a transient improvement of respiratory function but it was not enough.
T144	566-779	Sentence	denotes	Presumably, the consequences of the hyperinflammatory syndrome (thrombosis, alveolar damage and severe tissue hypoxia) were irreversible at the moment of treatment and patient died as consequence of these factors.