PMC:7784786 / 14695-15431 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"520","span":{"begin":250,"end":253},"obj":"Gene"},{"id":"521","span":{"begin":400,"end":407},"obj":"Gene"},{"id":"522","span":{"begin":445,"end":448},"obj":"Gene"},{"id":"523","span":{"begin":640,"end":643},"obj":"Gene"},{"id":"524","span":{"begin":12,"end":21},"obj":"Species"},{"id":"525","span":{"begin":22,"end":30},"obj":"Species"},{"id":"526","span":{"begin":122,"end":130},"obj":"Species"},{"id":"527","span":{"begin":188,"end":195},"obj":"Species"},{"id":"528","span":{"begin":597,"end":605},"obj":"Species"},{"id":"529","span":{"begin":208,"end":214},"obj":"Chemical"},{"id":"530","span":{"begin":263,"end":273},"obj":"Chemical"},{"id":"531","span":{"begin":363,"end":382},"obj":"Chemical"},{"id":"532","span":{"begin":384,"end":395},"obj":"Chemical"},{"id":"533","span":{"begin":48,"end":68},"obj":"Disease"},{"id":"534","span":{"begin":83,"end":116},"obj":"Disease"},{"id":"535","span":{"begin":477,"end":486},"obj":"Disease"},{"id":"536","span":{"begin":545,"end":558},"obj":"Disease"},{"id":"537","span":{"begin":582,"end":596},"obj":"Disease"}],"attributes":[{"id":"A520","pred":"tao:has_database_id","subj":"520","obj":"Gene:923"},{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"Gene:3440"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"Gene:26503"},{"id":"A523","pred":"tao:has_database_id","subj":"523","obj":"Gene:26503"},{"id":"A524","pred":"tao:has_database_id","subj":"524","obj":"Tax:2697049"},{"id":"A525","pred":"tao:has_database_id","subj":"525","obj":"Tax:9606"},{"id":"A526","pred":"tao:has_database_id","subj":"526","obj":"Tax:9606"},{"id":"A527","pred":"tao:has_database_id","subj":"527","obj":"Tax:9606"},{"id":"A528","pred":"tao:has_database_id","subj":"528","obj":"Tax:9606"},{"id":"A529","pred":"tao:has_database_id","subj":"529","obj":"MESH:D010100"},{"id":"A530","pred":"tao:has_database_id","subj":"530","obj":"MESH:C000597346"},{"id":"A531","pred":"tao:has_database_id","subj":"531","obj":"MESH:C558899"},{"id":"A532","pred":"tao:has_database_id","subj":"532","obj":"MESH:D002738"},{"id":"A533","pred":"tao:has_database_id","subj":"533","obj":"MESH:D012128"},{"id":"A535","pred":"tao:has_database_id","subj":"535","obj":"MESH:D003643"},{"id":"A536","pred":"tao:has_database_id","subj":"536","obj":"MESH:D058186"},{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"MESH:D016638"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These three SARS-CoV2 patients developed severe respiratory distress together with multifocal interstitial pneumonia. Two patients required invasive mechanical ventilation while the third patient only needed oxygen supply. They all received the anti-CD6 antibody itolizumab in combination with other drugs incorporated into the Cuban national protocol, including lopinavir/ritonavir, chloroquine and IFNα-2b. Regarding to laboratory parameters, AST is strongly associated with mortality risk compared with other parameters, reflecting liver and kidney injury [26,27]. In our cases, critically ill patients showed a significant reduction of AST concentration after the treatment suggesting an improvement in the function of these organs."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T52","span":{"begin":48,"end":68},"obj":"Phenotype"},{"id":"T53","span":{"begin":107,"end":116},"obj":"Phenotype"}],"attributes":[{"id":"A52","pred":"hp_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/HP_0002098"},{"id":"A53","pred":"hp_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/HP_0002090"}],"text":"These three SARS-CoV2 patients developed severe respiratory distress together with multifocal interstitial pneumonia. Two patients required invasive mechanical ventilation while the third patient only needed oxygen supply. They all received the anti-CD6 antibody itolizumab in combination with other drugs incorporated into the Cuban national protocol, including lopinavir/ritonavir, chloroquine and IFNα-2b. Regarding to laboratory parameters, AST is strongly associated with mortality risk compared with other parameters, reflecting liver and kidney injury [26,27]. In our cases, critically ill patients showed a significant reduction of AST concentration after the treatment suggesting an improvement in the function of these organs."}

{"project":"LitCovid-sentences","denotations":[{"id":"T131","span":{"begin":0,"end":117},"obj":"Sentence"},{"id":"T132","span":{"begin":118,"end":222},"obj":"Sentence"},{"id":"T133","span":{"begin":223,"end":408},"obj":"Sentence"},{"id":"T134","span":{"begin":409,"end":567},"obj":"Sentence"},{"id":"T135","span":{"begin":568,"end":736},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These three SARS-CoV2 patients developed severe respiratory distress together with multifocal interstitial pneumonia. Two patients required invasive mechanical ventilation while the third patient only needed oxygen supply. They all received the anti-CD6 antibody itolizumab in combination with other drugs incorporated into the Cuban national protocol, including lopinavir/ritonavir, chloroquine and IFNα-2b. Regarding to laboratory parameters, AST is strongly associated with mortality risk compared with other parameters, reflecting liver and kidney injury [26,27]. In our cases, critically ill patients showed a significant reduction of AST concentration after the treatment suggesting an improvement in the function of these organs."}