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PMC:7784786 / 13168-14096 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
458 75-79 Gene denotes IL-6 Gene:3569
459 269-273 Gene denotes IL-6 Gene:3569
460 356-360 Gene denotes IL-6 Gene:3569
461 510-514 Gene denotes IL-6 Gene:3569
462 766-770 Gene denotes IL-6 Gene:3569
463 902-905 Gene denotes CRS Gene:7291
464 202-205 Gene denotes CRS Gene:7291
465 0-3 Gene denotes CRS Gene:7291
466 167-175 Species denotes patients Tax:9606
467 310-318 Species denotes patients Tax:9606
468 418-426 Species denotes patients Tax:9606
469 591-599 Species denotes patients Tax:9606
470 666-674 Species denotes patients Tax:9606
471 798-806 Species denotes patients Tax:9606
472 870-878 Species denotes patients Tax:9606
473 613-623 Chemical denotes itolizumab MESH:C000597346
474 158-166 Disease denotes COVID-19 MESH:C000657245
475 225-248 Disease denotes hallmark of the disease MESH:D003141
476 301-309 Disease denotes COVID-19 MESH:C000657245
477 537-545 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T118 0-62 Sentence denotes CRS is characterized by high levels of inflammatory cytokines.
T119 63-145 Sentence denotes Among them, IL-6 is considered a major mediator of this hyperinflammation [18,19].
T120 146-254 Sentence denotes Most of the COVID-19 patients-related papers showed the CRS as one of the main hallmark of the disease [20].
T121 255-324 Sentence denotes Additionally, IL-6 levels predict severity in COVID-19 patients [21].
T122 325-427 Sentence denotes There is high heterogeneity of IL-6 values among papers for classifying severe and nonsevere patients.
T123 428-575 Sentence denotes In a large meta-analysis of 52 manuscripts, Elshazli and coworkers found that the IL-6 level associated with COVID-19 severity was 22.9 pg/ml [22].
T124 576-739 Sentence denotes In a series of patients treated with itolizumab a cutoff of 28 pg/ml discriminates severe patients from nonsevere (manuscript just accepted in Immunity and Aging).
T125 740-829 Sentence denotes In the present study, the IL-6 concentration of the three patients was above this cutoff.
T126 830-928 Sentence denotes It confirms the classification of these patients as severe and that the CRS is probably occurring.