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PMC:7784786 / 13157-16527 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
458 86-90 Gene denotes IL-6 Gene:3569
459 280-284 Gene denotes IL-6 Gene:3569
460 367-371 Gene denotes IL-6 Gene:3569
461 521-525 Gene denotes IL-6 Gene:3569
462 777-781 Gene denotes IL-6 Gene:3569
463 913-916 Gene denotes CRS Gene:7291
464 213-216 Gene denotes CRS Gene:7291
465 11-14 Gene denotes CRS Gene:7291
466 178-186 Species denotes patients Tax:9606
467 321-329 Species denotes patients Tax:9606
468 429-437 Species denotes patients Tax:9606
469 602-610 Species denotes patients Tax:9606
470 677-685 Species denotes patients Tax:9606
471 809-817 Species denotes patients Tax:9606
472 881-889 Species denotes patients Tax:9606
473 624-634 Chemical denotes itolizumab MESH:C000597346
474 169-177 Disease denotes COVID-19 MESH:C000657245
475 236-259 Disease denotes hallmark of the disease MESH:D003141
476 312-320 Disease denotes COVID-19 MESH:C000657245
477 548-556 Disease denotes COVID-19 MESH:C000657245
490 1129-1132 Gene denotes CD6 Gene:923
491 1194-1197 Gene denotes CD6 Gene:923
492 1287-1291 Gene denotes IL-6 Gene:3569
493 1293-1298 Gene denotes IFN-γ Gene:3458
494 1300-1305 Gene denotes TNF-α Gene:7124
495 1310-1315 Gene denotes IL-17 Gene:3605
496 1146-1149 Gene denotes CRS Gene:7291
497 1170-1178 Species denotes patients Tax:9606
498 1031-1039 Disease denotes COVID-19 MESH:C000657245
499 1161-1169 Disease denotes COVID-19 MESH:C000657245
500 1446-1457 Disease denotes lymphopenia MESH:D008231
501 1516-1528 Disease denotes cytotoxicity MESH:D064420
520 1788-1791 Gene denotes CD6 Gene:923
521 1938-1945 Gene denotes IFNα-2b Gene:3440
522 1983-1986 Gene denotes AST Gene:26503
523 2178-2181 Gene denotes AST Gene:26503
524 1550-1559 Species denotes SARS-CoV2 Tax:2697049
525 1560-1568 Species denotes patients Tax:9606
526 1660-1668 Species denotes patients Tax:9606
527 1726-1733 Species denotes patient Tax:9606
528 2135-2143 Species denotes patients Tax:9606
529 1746-1752 Chemical denotes oxygen MESH:D010100
530 1801-1811 Chemical denotes itolizumab MESH:C000597346
531 1901-1920 Chemical denotes lopinavir/ritonavir MESH:C558899
532 1922-1933 Chemical denotes chloroquine MESH:D002738
533 1586-1606 Disease denotes respiratory distress MESH:D012128
534 1621-1654 Disease denotes multifocal interstitial pneumonia
535 2015-2024 Disease denotes mortality MESH:D003643
536 2083-2096 Disease denotes kidney injury MESH:D058186
537 2120-2134 Disease denotes critically ill MESH:D016638
543 2483-2491 Species denotes patients Tax:9606
544 2581-2589 Species denotes patients Tax:9606
545 2275-2285 Chemical denotes Itolizumab MESH:C000597346
546 2507-2517 Chemical denotes itolizumab MESH:C000597346
547 2331-2365 Disease denotes opportunistic secondary infections MESH:D060085
562 2629-2633 Gene denotes IL-6 Gene:3569
563 2731-2735 Gene denotes IL-6 Gene:3569
564 2878-2882 Gene denotes IL-6 Gene:3569
565 2982-2986 Gene denotes IL-6 Gene:3569
566 2777-2784 Species denotes patient Tax:9606
567 3325-3332 Species denotes patient Tax:9606
568 2937-2947 Chemical denotes itolizumab MESH:C000597346
569 2785-2789 Disease denotes died MESH:D003643
570 2823-2851 Disease denotes cardiovascular complications MESH:D002318
571 3193-3219 Disease denotes hyperinflammatory syndrome MESH:D061325
572 3221-3231 Disease denotes thrombosis MESH:D013927
573 3233-3248 Disease denotes alveolar damage MESH:D055370
574 3267-3274 Disease denotes hypoxia MESH:D000860
575 3333-3337 Disease denotes died MESH:D003643

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T51 1446-1457 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T52 1586-1606 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T53 1645-1654 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T54 3267-3274 Phenotype denotes hypoxia http://purl.obolibrary.org/obo/HP_0012418

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T117 0-10 Sentence denotes Discussion
T118 11-73 Sentence denotes CRS is characterized by high levels of inflammatory cytokines.
T119 74-156 Sentence denotes Among them, IL-6 is considered a major mediator of this hyperinflammation [18,19].
T120 157-265 Sentence denotes Most of the COVID-19 patients-related papers showed the CRS as one of the main hallmark of the disease [20].
T121 266-335 Sentence denotes Additionally, IL-6 levels predict severity in COVID-19 patients [21].
T122 336-438 Sentence denotes There is high heterogeneity of IL-6 values among papers for classifying severe and nonsevere patients.
T123 439-586 Sentence denotes In a large meta-analysis of 52 manuscripts, Elshazli and coworkers found that the IL-6 level associated with COVID-19 severity was 22.9 pg/ml [22].
T124 587-750 Sentence denotes In a series of patients treated with itolizumab a cutoff of 28 pg/ml discriminates severe patients from nonsevere (manuscript just accepted in Immunity and Aging).
T125 751-840 Sentence denotes In the present study, the IL-6 concentration of the three patients was above this cutoff.
T126 841-939 Sentence denotes It confirms the classification of these patients as severe and that the CRS is probably occurring.
T127 940-1051 Sentence denotes Several anticytokine therapies have been tried for treating the hyperinflammatory phase of COVID-19 [20,23–25].
T128 1052-1179 Sentence denotes Here, we report the use of a well-known anti-inflammatory antibody targeting CD6 to treat the CRS arising in COVID-19 patients.
T129 1180-1411 Sentence denotes Using an anti-CD6 antibody could reduce the concentration of several pro-inflammatory cytokines, including IL-6, IFN-γ, TNF-α and IL-17, among others, representing an advantage as compared with single-cytokine targeting antibodies.
T130 1412-1537 Sentence denotes The antibody would not exacerbate lymphopenia since it does not induce complement or antibody dependent cytotoxicity [10,11].
T131 1538-1655 Sentence denotes These three SARS-CoV2 patients developed severe respiratory distress together with multifocal interstitial pneumonia.
T132 1656-1760 Sentence denotes Two patients required invasive mechanical ventilation while the third patient only needed oxygen supply.
T133 1761-1946 Sentence denotes They all received the anti-CD6 antibody itolizumab in combination with other drugs incorporated into the Cuban national protocol, including lopinavir/ritonavir, chloroquine and IFNα-2b.
T134 1947-2105 Sentence denotes Regarding to laboratory parameters, AST is strongly associated with mortality risk compared with other parameters, reflecting liver and kidney injury [26,27].
T135 2106-2274 Sentence denotes In our cases, critically ill patients showed a significant reduction of AST concentration after the treatment suggesting an improvement in the function of these organs.
T136 2275-2366 Sentence denotes Itolizumab was very safe and did not seem to exacerbate opportunistic secondary infections.
T137 2367-2492 Sentence denotes Unfortunately, we did no measure neither the frequency nor the total amount of circulating T cells in these initial patients.
T138 2493-2590 Sentence denotes The impact of itolizumab on circulating T cells are being implementing in new recruited patients.
T139 2591-2772 Sentence denotes Our preliminary findings support that IL-6 levels correlated with the severity of the disease and that the antibody was capable of reducing IL-6 concentration in all three subjects.
T140 2773-2852 Sentence denotes One patient died after subsequent respiratory and cardiovascular complications.
T141 2853-2957 Sentence denotes In this particular case, IL-6 concentration was extremely elevated at the moment of itolizumab infusion.
T142 2958-3075 Sentence denotes Although, the levels of IL-6 decreased during treatment, the values at 7 days kept still very high (above 300 pg/ml).
T143 3076-3156 Sentence denotes There was a transient improvement of respiratory function but it was not enough.
T144 3157-3370 Sentence denotes Presumably, the consequences of the hyperinflammatory syndrome (thrombosis, alveolar damage and severe tissue hypoxia) were irreversible at the moment of treatment and patient died as consequence of these factors.