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PMC:7784786 / 11790-13155 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
412 26-34 Species denotes patients Tax:9606
413 466-473 Species denotes patient Tax:9606
414 173-183 Chemical denotes itolizumab MESH:C000597346
415 53-61 Disease denotes COVID-19 MESH:C000657245
416 76-90 Disease denotes critically ill MESH:D016638
417 346-354 Disease denotes COVID-19 MESH:C000657245
428 717-721 Gene denotes IL-6 Gene:3569
429 763-772 Gene denotes IL-1 beta Gene:3552
430 773-779 Gene denotes IL-1F2 Gene:3553
431 824-829 Gene denotes TNF-α Gene:7124
432 881-885 Gene denotes IL-6 Gene:3569
433 640-645 Species denotes human Tax:9606
434 711-716 Species denotes human Tax:9606
435 757-762 Species denotes human Tax:9606
436 818-823 Species denotes human Tax:9606
437 701-703 CellLine denotes MN CVCL:U508

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T107 0-19 Sentence denotes Materials & methods
T108 20-264 Sentence denotes Three patients with diagnosis of COVID-19 classified as critically ill (two) and severely ill (one) were included in an expanded access trial to receive itolizumab in addition to standard treatment (http://rpcec.sld.cu/trials/RPCEC00000311-En).
T109 265-399 Sentence denotes The study was approved by a central ethical review board, created especially for COVID-19 and by the Cuban Regulatory Agency (CECMED).
T110 400-474 Sentence denotes Before the treatment, informed consent was obtained from enrolled patient.
T111 475-584 Sentence denotes Laboratory results included blood routine, leucocyte subsets and blood biochemical parameters were collected.
T112 585-865 Sentence denotes The level of inflammatory cytokines was measured using human validated commercially available kit from R&D Systems (MN, USA): human IL-6 Quantikine ELISA Kit (Cat# S6050), human IL-1 beta/IL-1F2 Quantikine ELISA Kit (Cat# SLB50) and human TNF-α Quantikine ELISA Kit (Cat# STA00D).
T113 866-959 Sentence denotes In the case of IL-6, the normal range of this cytokine in sera is between 0 and 7 pg/ml [17].
T114 960-1060 Sentence denotes We used intra-assay precision and inter-assay precision methods to evaluate precision in this study.
T115 1061-1210 Sentence denotes For intra-assay precision (precision within an assay), three samples of known concentration were tested on one plate to assess intra-assay precision.
T116 1211-1365 Sentence denotes For inter-assay precision (precision between assays), three samples of known concentration were tested in separate assays to assess inter-assay precision.