> top > docs > PMC:7784786 > spans > 1026-1930 > annotations

PMC:7784786 / 1026-1930 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
60 12-20 Species denotes patients Tax:9606
61 155-165 Species denotes SARS-COV-2 Tax:2697049
62 508-516 Species denotes patients Tax:9606
63 640-648 Species denotes patients Tax:9606
64 667-675 Species denotes patients Tax:9606
65 167-177 Chemical denotes Itolizumab MESH:C000597346
66 530-540 Chemical denotes itolizumab MESH:C000597346
67 590-600 Chemical denotes Itolizumab MESH:C000597346
68 3-11 Disease denotes COVID-19 MESH:C000657245
69 22-34 Disease denotes inflammation MESH:D007249
70 91-103 Disease denotes inflammation MESH:D007249
71 335-344 Disease denotes psoriasis MESH:D011565
72 393-405 Disease denotes inflammation MESH:D007249
73 484-498 Disease denotes critically ill MESH:D016638
74 499-507 Disease denotes COVID-19 MESH:C000657245
75 620-632 Disease denotes inflammation MESH:D007249
76 860-868 Disease denotes COVID-19 MESH:C000657245
77 894-903 Disease denotes mortality MESH:D003643

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T4 335-344 Phenotype denotes psoriasis http://purl.obolibrary.org/obo/HP_0003765

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T12 0-85 Sentence denotes In COVID-19 patients, inflammation is associated with the progression of the disease.
T13 86-166 Sentence denotes This inflammation comes from immune system activation in response to SARS-COV-2.
T14 167-245 Sentence denotes Itolizumab is an antibody that recognizes a protein expressed in immune cells.
T15 246-345 Sentence denotes The antibody has shown to be safe and efficacious in the treatment of moderate to severe psoriasis.
T16 346-435 Sentence denotes Its effect is associated with the reduction of inflammation and immune system activation.
T17 436-589 Sentence denotes Here, we report the outcome of three severe and critically ill COVID-19 patients treated with itolizumab as part of an expanded access clinical protocol.
T18 590-649 Sentence denotes Itolizumab was able to reduce inflammation in all patients.
T19 650-749 Sentence denotes Two of the three patients showed respiratory and radiological improvement and were fully recovered.
T20 750-904 Sentence denotes We hypothesize this anti-inflammatory therapy in addition to antiviral and anticoagulant therapy could reduce COVID-19 associated morbidity and mortality.