> top > docs > PMC:7781431 > spans > 8727-9584 > annotations

PMC:7781431 / 8727-9584 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
270 553-558 Gene denotes COX-2 Gene:5743
271 35-38 Chemical denotes DHA MESH:D004281
272 247-250 Chemical denotes DHA MESH:D004281
273 321-329 Chemical denotes peroxide MESH:D010545
274 369-372 Chemical denotes DHA MESH:D004281
275 437-445 Chemical denotes peroxide MESH:D010545
276 544-551 Chemical denotes aspirin MESH:D001241
277 568-571 Chemical denotes DHA MESH:D004281
278 575-589 Chemical denotes 13-hydroxy-DHA
279 593-608 Chemical denotes 17R-hydroxy-DHA

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T70 0-39 Sentence denotes RvD is a polyhydroxy metabolite of DHA.
T71 40-197 Sentence denotes To date, six RvDs with different positions of cis-trans isomers, as well as the number, position and chirality of the hydroxyl residues have been discovered.
T72 198-299 Sentence denotes D-series Rvs (RvD1-RvD6) are biosynthesized from DHA by the LOX in PMN and macrophages (Serhan et al.
T73 300-306 Sentence denotes 2002).
T74 307-396 Sentence denotes Hydrolysis of peroxide intermediates derived from two LOXs in DHA produces RvD1 and RvD2.
T75 397-488 Sentence denotes On the other hand, the reduction of the peroxide intermediates produces RvD5 (Serhan et al.
T76 489-495 Sentence denotes 2002).
T77 496-696 Sentence denotes In hypoxic endothelial cells in the presence of aspirin, COX-2 converts DHA to 13-hydroxy-DHA or 17R-hydroxy-DHA and activated PMN converts these products to AT-RvD1, AT-RvD2, and other AT-RvD-series.
T78 697-857 Sentence denotes RvD3 and RvD4 are produced through hydrolysis of 4S-hydroperoxy-17S-hydroxy-docosahexaenoic acid, whereas RvD6 is derived from peroxidase of the same precursor.